Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/75555
Título: Contribution of Extramedullary Hematopoiesis to Atherosclerosis. The Spleen as a Neglected Hub of Inflammatory Cells
Autores/as: Fernández-García, Victoria
González-Ramos, Silvia
Martín-Sanz, Paloma
Castrillo, Antonio 
Boscá, Lisardo
Clasificación UNESCO: 320702 Artereoesclerosis
320704 Patología cardiovascular
320602 Metabolismo energético
Palabras clave: Atherogenesis
Extramedullar Manifestations
Hematopoiesis
Inflammation
Spleen
Fecha de publicación: 2020
Publicación seriada: Frontiers In Immunology
Resumen: Cardiovascular diseases (CVDs) incidence is becoming higher. This fact is promoted by metabolic disorders such as obesity, and aging. Atherosclerosis is the underlying cause of most of these pathologies. It is a chronic inflammatory disease that begins with the progressive accumulation of lipids and fibrotic materials in the blood-vessel wall, which leads to massive leukocyte recruitment. Rupture of the fibrous cap of the atherogenic cusps is responsible for tissue ischemic events, among them myocardial infarction. Extramedullary hematopoiesis (EMH), or blood cell production outside the bone marrow (BM), occurs when the normal production of these cells is impaired (chronic hematological and genetic disorders, leukemia, etc.) or is altered by metabolic disorders, such as hypercholesterolemia, or after myocardial infarction. Recent studies indicate that the main EMH tissues (spleen, liver, adipose and lymph nodes) complement the hematopoietic function of the BM, producing circulating inflammatory cells that infiltrate into the atheroma. Indeed, the spleen, which is a secondary lymphopoietic organ with high metabolic activity, contains a reservoir of myeloid progenitors and monocytes, constituting an important source of inflammatory cells to the atherosclerotic lesion. Furthermore, the spleen also plays an important role in lipid homeostasis and immune-cell selection. Interestingly, clinical evidence from splenectomized subjects shows that they are more susceptible to developing pathologies, such as dyslipidemia and atherosclerosis due to the loss of immune selection. Although CVDs represent the leading cause of death worldwide, the mechanisms involving the spleen-atherosclerosis-heart axis cross-talk remain poorly characterized.
URI: http://hdl.handle.net/10553/75555
DOI: 10.3389/fimmu.2020.586527
Fuente: Frontiers in Immunology [EISSN 1664-3224], v. 11, 586527, (Octubre 2020)
Colección:Reseña
miniatura
Adobe PDF (3,23 MB)
Vista completa

Citas SCOPUSTM   

23
actualizado el 24-mar-2024

Visitas

55
actualizado el 27-ene-2024

Descargas

70
actualizado el 27-ene-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.