Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/75272
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dc.contributor.authorRecio Cruz, Carlota Pilaren_US
dc.contributor.authorLucy, Danielen_US
dc.contributor.authorIveson, Poppyen_US
dc.contributor.authorIqbal, Asif J.en_US
dc.contributor.authorValaris, Sophiaen_US
dc.contributor.authorWynne, Grahamen_US
dc.contributor.authorRussell, Angela J.en_US
dc.contributor.authorChoudhury, Robin P.en_US
dc.contributor.authorO'Callaghan, Chrisen_US
dc.contributor.authorMonaco, Claudiaen_US
dc.contributor.authorGreaves, David R.en_US
dc.date.accessioned2020-11-09T16:05:24Z-
dc.date.available2020-11-09T16:05:24Z-
dc.date.issued2018en_US
dc.identifier.issn1523-0864en_US
dc.identifier.urihttp://hdl.handle.net/10553/75272-
dc.description.abstractGreat attention has been placed on the link between metabolism and immune function giving rise to the term "immunometabolism." It is widely accepted that inflammation and oxidative stress are key processes that underlie metabolic complications during obesity, diabetes, and atherosclerosis. Therefore, identifying the mechanisms and mediators that are involved in the regulation of both inflammation and metabolic homeostasis is of high scientific and therapeutic interest. Recent Advances: G protein-coupled receptors (GPCRs) that signal in response to metabolites have emerged as attractive therapeutic targets in inflammatory disease. Critical Issues and Future Directions: In this review, we discuss recent findings about the physiological role of the main metabolite-sensing GPCRs, their implication in immunometabolic disorders, their principal endogenous and synthetic ligands, and their potential as drug targets in inflammation and metabolic disease.en_US
dc.languageengen_US
dc.relation.ispartofAntioxidants and Redox Signalingen_US
dc.sourceAntioxidants and Redox Signaling [ISSN 1523-0864], v. 29 (3), p. 237-256en_US
dc.subject320502 Endocrinologíaen_US
dc.subject.otherImmunometabolismen_US
dc.subject.otherDiabetesen_US
dc.subject.otherInflammationen_US
dc.subject.otherOxidative stressen_US
dc.subject.otherG protein-coupled receptorsen_US
dc.titleThe Role of Metabolite-Sensing G Protein-Coupled Receptors in Inflammation and Metabolic Diseaseen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1089/ars.2017.7168en_US
dc.identifier.issue3-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcNoen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr2,151
dc.description.jcr5,828
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-8832-2826-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRecio Cruz, Carlota Pilar-
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