Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/75025
Título: Toxicity and neuropharmacological effects of elenine
Autores/as: Navarro, Eduardo
Alonso, S. J.
Navarro Garcia, Ricardo 
Clasificación UNESCO: 32 Ciencias médicas
Palabras clave: Sex-Differences
Elenoside
Lignans
Fecha de publicación: 2011
Publicación seriada: Evidence-Based Complementary and Alternative Medicine 
Resumen: Elenine is the aglycone of elenoside, a cytotoxic arylnaphthalene lignan (NSC 644013-W/1) derived from Justicia hyssopifolia. (Family: Acanthaceae). Elenoside is a -D-glucoside, with a similar chemical structure to etoposide, exhibiting central depressant activity. In the present study, elenine was given to mice and rats at doses of 10, 20, and 40mg/kg. Acute toxicity (24h) and general behaviour in mice was studied as well as its effects on muscular relaxant activity, locomotor activity (Varimex test), and the open-field test and were compared with 10mg/kg of chlorpromazine. Elenine produced a reduction in the permanence time in muscular relaxant activity (traction test). Spontaneous activity was lower in the Varimex test. The ambulation and rearing were lower compared with the control group, and an increase in boluses was observed in the open-field test. Thus, it can be concluded that elenine has central sedative effects at lower doses than those used with elenoside and has a possible application in conditions of anxiety.
URI: http://hdl.handle.net/10553/75025
ISSN: 1741-427X
DOI: 10.1155/2011/312524
Fuente: Evidence-based Complementary and Alternative Medicine [ISSN 1741-427X], v. 2011
Colección:Artículos
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