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Title: Dirofilaria immitis could be a risk factor for the development of allergic diseases in humans
Authors: Montoya Alonso, José Alberto 
Morchon Garcia,Rodrigo 
Matos Rivero, Jorge Isidoro 
Falcón Cordón, Yaiza 
Costa Rodríguez, Noelia 
Carretón Gómez, Elena 
UNESCO Clasification: 310907 Patología
Keywords: Dirofilaria immitis
Canary Islands
Human dirofilariosis
Zoonosis, et al
Issue Date: 2020
Journal: Animals 
Abstract: The Canary Islands are hyperendemic for canine heartworm and the risk of zoonotic infection is high. Additionally, there is evidence of development of allergies due to nematode infections in animals and humans. Since the population of the Canary Islands presents high prevalence of allergic comorbidities, and previous studies have shown a possible relationship between allergies and seropositivity to heartworm, the aim was to evaluate whether exposure to heartworm may contribute to the development of allergies in the human population. First, an epidemiological study was conducted on 248 owners of dogs with/without heartworm infection in the Canary Islands. Secondly, a serological analysis of the presence of total IgE and specific IgE against heartworm was conducted in 66 samples of inhabitants of the Canary Islands. The survey showed that allergic owners had heartworm-positive dogs more frequently (p < 0.01). Of the analyzed human samples, 43.9% were seropositive to heartworm and Wolbachia. Total IgE concentrations were increased in 34.5% seropositive samples and 8.1% seronegative samples. Specific IgE against heartworm was only found in human seropositive samples (17.2%). Contact with heartworm may be a risk factor for the development of allergic diseases, although further studies to elucidate the relationship between heartworm and allergies should be carried out.
ISSN: 2076-2615
DOI: 10.3390/ani10101847
Source: Animals [EISSN 2076-2615], v. 10 (10), p. 1847, (October 2020)
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