Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/74670
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dc.contributor.authorParreira, José Ricardoen_US
dc.contributor.authorHernández Castellano, Lorenzo Enriqueen_US
dc.contributor.authorArgüello Henríquez, Anastasioen_US
dc.contributor.authorCapote Álvarez, Juan Franciscoen_US
dc.contributor.authorCastro Navarro, Noemíen_US
dc.contributor.authorde Sousa Araújo, Susanaen_US
dc.contributor.authorde Almeida, André Martinhoen_US
dc.date.accessioned2020-10-07T11:24:31Z-
dc.date.available2020-10-07T11:24:31Z-
dc.date.issued2020en_US
dc.identifier.issn1471-2164en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/74670-
dc.description.abstractSeasonal weight loss (SWL) is a very important limitation to the production of ruminants in the Mediterranean and Tropical regions. In these areas, long dry seasons lead to poor pastures with low nutritional value. During the dry season, ruminants, particularly those raised in extensive production systems, lose around 30% of their body weight. Seasonal weight loss has important consequences on animal productive performance and health. In this study, RNA sequencing was used to characterize feed restriction effects in dairy goat of 2 breeds with different SWL tolerance: Majorera (tolerant) and Palmera (susceptible). Nine Majorera and ten Palmera goats were randomly distributed in a control and a restricted group: Majorera Control (adequately fed; MC; n = 4), Palmera Control (adequately fed; PC; n = 6), Majorera Restricted (feed restricted; ME; n = 5) and Palmera Restricted (feed restricted; PE; n = 4). On day 22 of the trial, mammary gland biopsies were collected for transcriptomics analysis. RESULTS: From these samples, 24,260 unique transcripts were identified. From those, 82 transcripts were differentially expressed between MC and ME, 99 between PC and PE, twelve between both control groups and twenty-nine between both restricted groups. CONCLUSIONS: Feed restriction affected several biochemical pathways in both breeds such as: carbohydrate and lipid transport; intracellular trafficking, RNA processing and signal transduction. This research also highlights the importance or involvement of the genes in tolerance (ENPP1, S-LZ, MT2A and GPNB) and susceptibility (GPD1, CTPS1, ELOVL6 and NR4A1) to SWL with respectively higher expression in the Majorera restriced group and the Palmera restricted group in comparison to the control groups. In addition, results from the study may be extrapolated to other dairy ruminant species.en_US
dc.languageengen_US
dc.relation.ispartofBMC Genomicsen_US
dc.sourceBMC genomics [EISSN 1471-2164], v. 21 (1), 629, (Septiembre 2020)en_US
dc.subject3104 Producción Animalen_US
dc.subject.otherGoaten_US
dc.subject.otherMammary Glanden_US
dc.subject.otherRNA-Sequencingen_US
dc.subject.otherSeasonal Weight Lossen_US
dc.subject.otherTranscriptomicsen_US
dc.titleUnderstanding seasonal weight loss tolerance in dairy goats: a transcriptomics approachen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12864-020-06968-2en_US
dc.identifier.scopus85091050660-
dc.contributor.authorscopusid57219021575-
dc.contributor.authorscopusid36682092900-
dc.contributor.authorscopusid6701710018-
dc.contributor.authorscopusid6602424338-
dc.contributor.authorscopusid57200208399-
dc.contributor.authorscopusid57216776070-
dc.contributor.authorscopusid57211236623-
dc.identifier.eissn1471-2164-
dc.identifier.issue1-
dc.relation.volume21en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.date.coverdateSeptiembre 2020en_US
dc.identifier.ulpgcen_US
dc.description.sjr1,629
dc.description.jcr3,594
dc.description.sjrqQ1
dc.description.jcrqQ2
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptProducción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptProducción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptProducción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0003-2729-0434-
crisitem.author.orcid0000-0002-4426-0678-
crisitem.author.orcid0000-0002-3026-2031-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameHernández Castellano, Lorenzo Enrique-
crisitem.author.fullNameArgüello Henríquez, Anastasio-
crisitem.author.fullNameCapote Álvarez, Juan Francisco-
crisitem.author.fullNameCastro Navarro, Noemí-
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