Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/74604
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dc.contributor.authorSaavedra Santana, Ester Gloria-
dc.contributor.authorEstévez Sarmiento, Francisco-
dc.contributor.authorSaid, Mercedes-
dc.contributor.authorEiroa Martínez, José Luis-
dc.contributor.authorRubio Sánchez, Sara-
dc.contributor.authorQuintana, José-
dc.contributor.authorEstévez Rosas, Francisco Jesús-
dc.date.accessioned2020-09-30T09:26:29Z-
dc.date.available2020-09-30T09:26:29Z-
dc.date.issued2020-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10553/74604-
dc.description.abstractSpiciformin (1) is a sesquiterpene lactone with a germacrane skeleton that is found in two Tanacetum species endemic to the Canary Islands. In this study, the cytotoxicities of 1 and its acetyl derivative (2) were evaluated against human tumor cells. These sesquiterpene lactones were cytotoxic against human acute myeloid leukemia (U-937 and HL-60) cells, even in cells over-expressing the pro-survival protein Bcl-2, but melanoma (SK-MEL-1) and human mononuclear cells isolated from blood of healthy donors were more resistant. Both compounds are apoptotic inducers in human leukemia U-937 cells. Cell death was mediated by the processing and activation of initiator and effector caspases and the cleavage of poly(ADP-ribose) polymerase, and it was blocked by a broad-spectrum caspase inhibitor and (in the case of sesquiterpene lactone 2) by the selective caspase-3/7, -8, and -9 inhibitors. In addition, certainly in the case of compound 2, this was found to be associated with a decrease in mitochondrial membrane potential, downregulation of the anti-apoptotic protein Bcl-2, activation of the mitogen-activated protein kinases signaling pathway, and generation of reactive oxygen species. It will, therefore, be relevant to continue characterization of this class of compounds.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.sourceInternational Journal of Molecular Sciences [ISSN 1661-6596], v. 21 (8), 2782-
dc.subject2302 Bioquímica-
dc.subject.otherApoptosis-
dc.subject.otherCytotoxicity-
dc.subject.otherCaspase-
dc.subject.otherPoly(ADP-ribose) polymerase-
dc.subject.otherSesquiterpene lactone-
dc.titleCytotoxicity of the Sesquiterpene Lactone Spiciformin and Its Acetyl Derivative against the Human Leukemia Cell Lines U-937 and HL-60-
dc.typeinfo:eu-repo/semantics/article-
dc.typeArticle-
dc.identifier.doi10.3390/ijms21082782-
dc.relation.volume21-
dc.investigacionCiencias de la Salud-
dc.type2Artículo-
dc.description.notasThis article belongs to the Section Bioactives and Nutraceuticals-
dc.utils.revision-
dc.identifier.ulpgces
dc.description.sjr1,317
dc.description.jcr4,556
dc.description.sjrqQ1
dc.description.jcrqQ1
item.fulltextCon texto completo-
item.grantfulltextrestricted-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Química-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptBioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0002-4986-8332-
crisitem.author.orcid0000-0001-7633-1285-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSaavedra Santana, Ester Gloria-
crisitem.author.fullNameEstévez Sarmiento, Francisco-
crisitem.author.fullNameEiroa Martínez, José Luis-
crisitem.author.fullNameRubio Sánchez, Sara-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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