Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/74514
Campo DC Valoridioma
dc.contributor.authorSanchez-Cespedes, R.en_US
dc.contributor.authorMillan, Y.en_US
dc.contributor.authorGuil-Luna, S.en_US
dc.contributor.authorGarcia-Monterde, J.en_US
dc.contributor.authorReymundo, C.en_US
dc.contributor.authorEspinosa De Los Monteros Y Zayas, Antonioen_US
dc.contributor.authorMartin de las Mulas, J.en_US
dc.date.accessioned2020-09-21T11:32:20Z-
dc.date.available2020-09-21T11:32:20Z-
dc.date.issued2011en_US
dc.identifier.issn0021-9975en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/74514-
dc.description.abstractThe aim of this study was to determine whether the myoepithelial (ME) cell marker calponin could be used to analyze the integrity of the ME cell layer as a means of identifying canine mammary carcinoma in situ. Tissue from 74 canine mammary lesions was evaluated (two dysplasia, eight benign tumours and 64 carcinomas including one carcinoma in situ). The 63 carcinomas included examples of histological grade 1 (n = 32), grade 2 (n = 23) and grade 3 (n = 8). Expression of calponin was determined by immunohistochemistry. The percentage of proliferating cells surrounded by a single layer of calponin-positive cells formed the basis of classification as type I (>= 90%), type II (70-90%) and type III (>= 70%). Expression of Ki67 was used to determine the proliferation index (PI). The malignant tumours comprised of an approximately equal mixture of type I, II and III lesions. The two examples of dysplasia, the carcinoma in situ and two thirds of the benign tumours were classified as type T lesions. Some overlap in the level of calponin expression was observed between benign and malignant tumours. Positive correlations between the degree of calponin expression and the type of lesion (i.e. benign versus malignant; R = + 0.3, P = 0.08) and the histological grade of malignancy (R = + 0.54, P = 0.000001) were found. A negative correlation between the degree of calponin expression and PI (R = + 0.027, P = 0.016) was found. The ME cell marker calponin may be used as an aid in the identification of canine carcinoma in situ, hut the study of the ME cell layer integrity is not definitive for the diagnosis of malignancy in canine mammary tumours. (C) 2010 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Comparative Pathologyen_US
dc.sourceJournal Of Comparative Pathology [ISSN 0021-9975], v. 145 (1), p. 25-30, (Julio 2011)en_US
dc.subject310907 Patologíaen_US
dc.subject.otherTumorsen_US
dc.subject.otherDiagnosisen_US
dc.subject.otherLesionsen_US
dc.subject.otherDogsen_US
dc.subject.otherCalponinen_US
dc.subject.otherCanineen_US
dc.subject.otherCarcinoma In Situen_US
dc.subject.otherMammary Myoepitheliumen_US
dc.titleMyoepithelial Cell Layer Integrity in Canine Mammary Carcinomaen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jcpa.2010.11.006en_US
dc.identifier.scopus79956004047-
dc.identifier.isi000291833100005-
dc.contributor.authorscopusid35068575800-
dc.contributor.authorscopusid6603640503-
dc.contributor.authorscopusid26632922000-
dc.contributor.authorscopusid6506910439-
dc.contributor.authorscopusid6602625041-
dc.contributor.authorscopusid36928058400-
dc.contributor.authorscopusid57211742924-
dc.description.lastpage30en_US
dc.identifier.issue1-
dc.description.firstpage25en_US
dc.relation.volume145en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid19758239-
dc.contributor.daisngid619515-
dc.contributor.daisngid1353334-
dc.contributor.daisngid6829094-
dc.contributor.daisngid1431295-
dc.contributor.daisngid700159-
dc.contributor.daisngid407245-
dc.description.numberofpages6en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Sanchez-Cespedes, R-
dc.contributor.wosstandardWOS:Millan, Y-
dc.contributor.wosstandardWOS:Guil-Luna, S-
dc.contributor.wosstandardWOS:Garcia-Monterde, J-
dc.contributor.wosstandardWOS:Reymundo, C-
dc.contributor.wosstandardWOS:de los Monteros, AE-
dc.contributor.wosstandardWOS:de las Mulas, JM-
dc.date.coverdateJulio 2011en_US
dc.identifier.ulpgces
dc.description.sjr0,768
dc.description.jcr1,647
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0002-7736-3139-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameEspinosa De Los Monteros Y Zayas, Antonio-
Colección:Artículos
Vista resumida

Citas SCOPUSTM   

14
actualizado el 24-mar-2024

Citas de WEB OF SCIENCETM
Citations

14
actualizado el 25-feb-2024

Visitas

123
actualizado el 17-feb-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.