Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/74406
Title: Eimeria bovis: An update on parasite-host cell interactions
Authors: Hermosilla, Carlos
Ruiz Reyes, Antonio 
Taubert, Anja
UNESCO Clasification: 310907 Patología
240112 Parasitología animal
Keywords: Monocyte Chemotactic Protein-1
Molecule Gene-Transcription
Nf-Kappa-B
Toxoplasma-Gondii
In-Vitro
Endothelial-Cells
Microarray Analysis
Expression
Secretion
Infection
Eimeria Bovis
Apoptosis
Cytoskeleton
Immune Reaction
Host Cell Reaction
Issue Date: 2012
Journal: International Journal of Medical Microbiology 
Abstract: Apicomplexan parasites are obligate intracellular protozoans and are well recognized modulators of the host cell machinery on varying levels such as host cell metabolism, MHC expression, cell cycle, or apoptosis in order to guarantee their intracellular development and survival. One of the most thoroughly examined apicomplexan pathogens demonstrating a potent manipulative capacity with respect to various host cell functions is Toxoplasma gondii, a protozoon exhibiting rapid intracellular development with small meronts in any nucleated cell, almost irrespective of the cell type or host origin. In contrast, Eimeria bovis merogony I is host- and cell type-restricted and occurs exclusively in bovine endothelial host cells. Furthermore, as a peculiarity, intracellular E. bovis meront I development is a long-lasting process (up to 3 weeks), leading to the formation of huge macromeronts of up to 300 mu m size, containing up to 120,000 merozoites I as offspring. In consequence, the necessity for intense host cell modulation to support this particular development appears even more pressing than in other apicomplexan parasite cases. Here we review the data currently available on E. bovis-host cell interactions, indicating the intriguing capacity of this protozoan to exploit and utilize its host cell for its own benefit. (C) 2012 Elsevier GmbH. All rights reserved.
URI: http://hdl.handle.net/10553/74406
ISSN: 1438-4221
DOI: 10.1016/j.ijmm.2012.07.002
Source: International Journal Of Medical Microbiology [ISSN 1438-4221], v. 302 (4-5), p. 210-215, (Octubre 2012)
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