Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/74183
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dc.contributor.authorSuárez de Lezo, José Maríaen_US
dc.contributor.authorMedina, Alfonsoen_US
dc.contributor.authorPan, Manuelen_US
dc.contributor.authorDelgado, Antonioen_US
dc.contributor.authorSegura, Joséen_US
dc.contributor.authorPavlovic, Djordjeen_US
dc.contributor.authorMelián, Franciscoen_US
dc.contributor.authorRomero, Miguelen_US
dc.contributor.authorBurgos, Luisen_US
dc.contributor.authorHernández, Enriqueen_US
dc.contributor.authorUreña, Isabelen_US
dc.contributor.authorHerrador, Juanen_US
dc.date.accessioned2020-08-21T21:57:38Z-
dc.date.available2020-08-21T21:57:38Z-
dc.date.issued2004en_US
dc.identifier.issn0002-8703en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/74183-
dc.description.abstractBackground Conventional bare stents have been used to treat unprotected left main (LM) coronary artery stenosis. However, restenosis remains the main limitation. Since rapamycin-eluting stents (RES) appear to inhibit neointimal proliferation, their application to this specific site seems promising. Methods Since May 2002, we have studied a series of 52 patients with LM lesions treated with RES. Forty-seven patients presented with de novo stenoses, and 5 had in-stent restenosis; 19 patients required combined stent treatment for other remote lesions in the coronary tree, 6 of them at the level of proximal right coronary artery. The RES was implanted directly at the LM in 39 patients; 13 others needed predilation. Once deployed, the RES was overexpanded with short balloons adjusted to the LM length in 44 patients. Quantitative coronary angiograms were analyzed in the same view before and immediately after treatment and at follow-up. Patients were followed-up closely and new cardiac catheterization was scheduled at 6-month evaluation or earlier in the presence of symptoms. At follow-up study, quantitative coronary angiography and motorized intravascular ultrasound analyses were performed in 35 (67%) patients. Results Primary success was obtained in 50 patients (96%). Two patients (4%) developed a non-Q-wave myocardial infarction. All patients were symptom-free at discharge. After a mean follow-up of 12 ± 4 months, 50 patients (96%) remain asymptomatic. No late death or acute thrombosis have been recorded. Two patients became symptomatic 2 and 4 months after treatment, respectively. One had restenosis at a remote site, while the other had in-segment restenosis. None of the remaining 33 angiographically evaluated patients developed restenosis at any site. Target lesion revascularization was 1/52 (2%). Conclusions Although longer-term follow-up studies are needed, the tailored treatment of coronary lesions located at the LM by overexpanded RES is feasible and safe. Midterm results seem promising, which might help to shift the orientation of patient management from surgical to percutaneous revascularization.en_US
dc.languageengen_US
dc.relation.ispartofThe American heart journalen_US
dc.sourceAmerican Heart Journal [ISSN 0002-8703], v. 148 (3), p. 481-485, (Septiembre 2004)en_US
dc.subject320501 Cardiologíaen_US
dc.titleRapamycin-eluting stents for the treatment of unprotected left main coronary diseaseen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ahj.2004.03.011en_US
dc.identifier.scopus4644335241-
dc.contributor.authorscopusid7006785516-
dc.contributor.authorscopusid7202723590-
dc.contributor.authorscopusid7202544866-
dc.contributor.authorscopusid36147056600-
dc.contributor.authorscopusid55415591100-
dc.contributor.authorscopusid7005198171-
dc.contributor.authorscopusid7003549899-
dc.contributor.authorscopusid7202430759-
dc.contributor.authorscopusid57197075636-
dc.contributor.authorscopusid7402296666-
dc.contributor.authorscopusid6508268318-
dc.contributor.authorscopusid8204222400-
dc.description.lastpage485en_US
dc.identifier.issue3-
dc.description.firstpage481en_US
dc.relation.volume148en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.date.coverdateSeptiembre 2004en_US
dc.identifier.ulpgces
dc.description.jcr3,681
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
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