Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/74172
Título: Melatonin reduces oxidative neurotoxicity due to quinolinic acid: In vitro and in vivo findings
Autores/as: Cabrera, Javier
Reiter, Russel J.
Tan, Dun-Xian
Qi, Wenbo
Saínz, Rosa M.
Mayo, Juan Carlos
García, Joaquín J.
Kim, Seok Joong
El-Sokkary, Gamal
Clasificación UNESCO: 3209 Farmacología
Palabras clave: Melatonin
Quinolinic Acid
Lipid Peroxidation
Neurotoxicity
Free Radicals, et al.
Fecha de publicación: 2000
Publicación seriada: Neuropharmacology 
Resumen: The in vivo and in vitro effects of melatonin on quinolinic acid-induced oxidative damage in rat brain were determined. The concentrations of malonaldehyde and 4-hydroxyalkenals were assayed as an index of oxidatively damaged lipid. In in vitro experiments, the increase in malonaldehyde and 4-hydroxyalkenals concentrations induced by quinolinic acid were concentration-dependent and time-dependent. The accumulation of products of lipid peroxidation induced by quinolinic acid were very significantly reduced by melatonin in a concentration-dependent manner. Additionally, at the highest concentrations of melatonin used in quinolinic acid treated homogenates, it reduced the levels of oxidatively damaged lipid products below those measured in control homogenates (no quinolinic acid or melatonin). When quinolinic acid (200 mg/kg) was intraperitonally injected into Ii-day-old rats, lipid peroxidation in the brain was significantly increased 24 hours later compared to levels in control rats. When melatonin (10 mg/kg) was injected ip 30 min before and 4 and 20 hours after the administration of quinolinic acid, the increased lipid peroxidation induced by quinolinic acid was significantly reduced. Likewise, neurobehavioral signs associated with quinolinate administration were attenuated by melatonin. These results show that both in vitro and in vivo pharmacological levels of melatonin confer protection against quinolinic acid-induced oxidative toxicity in the brain. The findings also indicate that melatonin may be pharmacologically useful in combatting quinolinic neurotoxicity which is associated with several acute and chronic neurodegenerative neurological diseases.
URI: http://hdl.handle.net/10553/74172
ISSN: 0028-3908
DOI: 10.1016/S0028-3908(99)00128-8
Fuente: Neuropharmacology [ISSN 0028-3908], v. 39 (3), p. 507-514, (2000)
Colección:Artículos
Vista completa

Citas SCOPUSTM   

97
actualizado el 24-mar-2024

Citas de WEB OF SCIENCETM
Citations

88
actualizado el 25-feb-2024

Visitas

88
actualizado el 24-ene-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.