Ovaric and adrenal influence on the ontogeny of the cytosolic and nuclear uterine estrogen-receptor

Abstract

Adrenal and ovarian relative influence over rat uterus estrogenic receptor, both cytosolic (RcE) and nuclear (RnE) ontogenesis, has been studied. Ovarian influence has been studied by practising bilateral ovariectomy the first day of life and examining estrogenic receptor content evolution from, birth to puberty in these ovariectomized animals (OVX1) by comparison with the normal ones. This influence seems to be of scarce importance until the 20th day of life, since estrogenic receptors content is practically coincident in the OVX1 animals and in the control ones. From the 20th day, ovarian secretion influence increases and estrogenic receptor evolution starts evolving in a different way in the two types of animals. Adrenal influence has been studied by practising bilateral adrenalectomy on the 10th or 30th day of life to OVX1 animals or else OVX and ADX on the 10th or 30th day. Adrenal influence in the upkeep of high estrogen receptor levels on the 10th day, seems to be important, since in the absence of these glands it decreases in a considerable way. The situation is different on the 30th day. At this age ovarian secretion seems to be the most important in maintaining estrogen receptor levels, while adrenal secretion effects tend to inhibit them, especially RnE.