Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/73995
DC FieldValueLanguage
dc.contributor.authorZafra Leva,Rafaelen_US
dc.contributor.authorPerez-Ecija, R. A.en_US
dc.contributor.authorBuffoni, L.en_US
dc.contributor.authorMoreno, P.en_US
dc.contributor.authorBautista, M. J.en_US
dc.contributor.authorMartinez-Moreno, A.en_US
dc.contributor.authorMulcahy, G.en_US
dc.contributor.authorDalton, J. P.en_US
dc.contributor.authorPérez, J.en_US
dc.date.accessioned2020-08-06T09:58:59Z-
dc.date.available2020-08-06T09:58:59Z-
dc.date.issued2013en_US
dc.identifier.issn0021-9975en_US
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/73995-
dc.description.abstractThe aim of the present study was to study peritoneal and hepatic changes during early [7-9 days postinfection (dpi)] and late [15 weeks postinfection (wpi)] infection of goats immunized with recombinant F. hepatica pro cathepsin L1 (rCL1) in Quil A and challenged with Fasciola hepatica. Despite finding no significant reduction in fluke burdens between the control and immunized group, at 15 dpi the rCL1-vaccinated group showed significantly higher weight gain and reduced severity of hepatic lesions compared with the control group that received only Quil A. In the rCL1-vaccinated group, two of three goats sacrificed at 7-9 dpi had little hepatic damage and had a higher percentage of peritoneal eosinophils and elevated induced nitric oxide synthase (iNOS) expression in peritoneal cells than the goats from the control group. Moreover, while these two goats showed a heavy infiltration of eosinophils surrounding migrating flukes, the remaining animals examined at 7-9 dpi had no inflammatory infiltration surrounding migrating flukes. Two out of seven goats in the rCL1-vaccinated group had low fluke burdens and little hepatic damage at 15 wpi, suggesting an effective protective response in some of the vaccinated goats. This protective response did not correlate with peripheral eosinophilia or with serum titres of anti-rCL1 immunoglobulin (Ig) G. The results of the present work suggest that an eosinophil-mediated immune response plays a crucial role in the early effective host response against F. hepatica in goats. Adjuvants designed to increase cell-mediated immunity should be tested in future vaccine trials against F. hepatica.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Comparative Pathologyen_US
dc.sourceJournal of Comparative Pathology [ISSN 0021-9975], v. 148 (4), p. 373-384, (Mayo 2013)en_US
dc.subject240112 Parasitología animalen_US
dc.subject310907 Patologíaen_US
dc.subject.otherCathepsin L1en_US
dc.subject.otherFasciola Hepaticaen_US
dc.subject.otherGoaten_US
dc.subject.otherImmune Responseen_US
dc.titleEarly and Late Peritoneal and Hepatic Changes in Goats Immunized with Recombinant Cathepsin L1 and Infected with Fasciola hepaticaen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jcpa.2012.08.007en_US
dc.identifier.scopus84876804438-
dc.identifier.isi000319088300013-
dc.contributor.authorscopusid23029634000-
dc.contributor.authorscopusid56601461400-
dc.contributor.authorscopusid23567522100-
dc.contributor.authorscopusid56232387100-
dc.contributor.authorscopusid7006592846-
dc.contributor.authorscopusid15725365500-
dc.contributor.authorscopusid7003516821-
dc.contributor.authorscopusid7202787631-
dc.contributor.authorscopusid55597088351-
dc.identifier.eissn1532-3129-
dc.description.lastpage384en_US
dc.identifier.issue4-
dc.description.firstpage373en_US
dc.relation.volume148en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid770447-
dc.contributor.daisngid1856962-
dc.contributor.daisngid2280645-
dc.contributor.daisngid3571502-
dc.contributor.daisngid571008-
dc.contributor.daisngid984836-
dc.contributor.daisngid210954-
dc.contributor.daisngid102438-
dc.contributor.daisngid319037-
dc.description.numberofpages12en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Zafra, R-
dc.contributor.wosstandardWOS:Perez-Ecija, RA-
dc.contributor.wosstandardWOS:Buffoni, L-
dc.contributor.wosstandardWOS:Moreno, P-
dc.contributor.wosstandardWOS:Bautista, MJ-
dc.contributor.wosstandardWOS:Martinez-Moreno, A-
dc.contributor.wosstandardWOS:Mulcahy, G-
dc.contributor.wosstandardWOS:Dalton, JP-
dc.contributor.wosstandardWOS:Perez, J-
dc.date.coverdateMayo 2013en_US
dc.identifier.ulpgces
dc.description.sjr0,628
dc.description.jcr1,1
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.fullNameZafra Leva,Rafaael-
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