Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/73625
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dc.contributor.authorGutierrez-Bedmar, Marioen_US
dc.contributor.authorOlmedo, Pabloen_US
dc.contributor.authorGil, Fernandoen_US
dc.contributor.authorRuiz-Canela, Miguelen_US
dc.contributor.authorMartínez-González, Miguel A.en_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorBabio, Nancyen_US
dc.contributor.authorFito, Montserraten_US
dc.contributor.authordel Val, Jose L.en_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorSorli, Jose V.en_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorFiol, Miquelen_US
dc.contributor.authorEstruch, Ramónen_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorArós, Fernandoen_US
dc.contributor.authorSerra Majem, Luisen_US
dc.contributor.authorPintó, Xavieren_US
dc.contributor.authorGomez-Gracia, Enriqueen_US
dc.date.accessioned2020-07-06T09:38:45Z-
dc.date.available2020-07-06T09:38:45Z-
dc.date.issued2020en_US
dc.identifier.issn0261-5614en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/73625-
dc.description.abstractEpidemiological data on iron status and cardiovascular disease (CVD) are still controversial. The aim of this study was to determine whether low serum iron (SI) levels are associated with an increased odds of first CVD event in a population at high cardiovascular risk. Methods: Case-control study design nested within the “PREvención con DIeta MEDiterránea” (PREDIMED) trial. A total of 207 participants diagnosed with CVD (myocardial infarction, stroke or cardiovascular death) during follow-up period (2003–2010) were matched by sex, age and intervention group to 436 controls by incidence density sampling. Median time between serum sample collection and subsequent CVD event occurrence was 0.94 years. Inductively coupled plasma mass spectrometry analysis was used to determine SI levels. In-person interviews, medical record reviews, and validated questionnaires were used to assess covariates. Multivariable-adjusted odds ratios (ORs) of CVD were calculated with conditional logistic regression. Results: Mean SI levels were higher in men than in women (1224.0 μg/L vs. 1093.8 μg/L; p < 0.001). Among women, but not in men, the mean SI concentration was lower in cases than in controls (1008.5 μg/L vs. 1132.9 μg/L; p = 0.030). There was a gradual decrease in the multivariable-adjusted ORs of CVD with increasing SI levels (highest vs. lowest quartile: OR = 0.55, 95% CI: 0.32–0.93; ptrend = 0.020). This inverse relationship was more pronounced among women (highest vs. lowest quartile: OR = 0.15, 95% CI: 0.03–0.69; ptrend = 0.011). Conclusions: The present findings are consistent with previously reported inverse associations between SI and CVD. SI levels as an independent marker of short-term cardiovascular risk may be useful for risk assessment in older populations. Trial registration: www.controlled-trials.com; International Standard Randomized Controlled Trial Number (ISRCTN): 35,739,639. Registered 5 October 2005. Retrospectively registered.en_US
dc.languageengen_US
dc.relation.ispartofClinical Nutritionen_US
dc.sourceClinical Nutrition [ISSN 0261-5614], (Enero 2020)en_US
dc.subject320501 Cardiologíaen_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherCardiovascular Diseaseen_US
dc.subject.otherOlder Populationsen_US
dc.subject.otherPredimeden_US
dc.subject.otherProspective Studiesen_US
dc.subject.otherSerum Ironen_US
dc.titleLow serum iron levels and risk of cardiovascular disease in high risk elderly population: Nested case–control study in the PREvención con DIeta MEDiterránea (PREDIMED) trialen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.clnu.2020.05.044en_US
dc.identifier.scopus85086862846-
dc.contributor.authorscopusid6506505275-
dc.contributor.authorscopusid55890385300-
dc.contributor.authorscopusid7102457263-
dc.contributor.authorscopusid6603417884-
dc.contributor.authorscopusid7004290629-
dc.contributor.authorscopusid7003357665-
dc.contributor.authorscopusid24279242400-
dc.contributor.authorscopusid6602891390-
dc.contributor.authorscopusid57216160827-
dc.contributor.authorscopusid7003570538-
dc.contributor.authorscopusid7004605575-
dc.contributor.authorscopusid35474202600-
dc.contributor.authorscopusid7005315313-
dc.contributor.authorscopusid7005989830-
dc.contributor.authorscopusid6507771144-
dc.contributor.authorscopusid7004158382-
dc.contributor.authorscopusid35596972100-
dc.contributor.authorscopusid57214783328-
dc.contributor.authorscopusid57202571697-
dc.identifier.eissn1532-1983-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.date.coverdateEnero 2020en_US
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptNutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
crisitem.author.departamentoCiencias Clínicas-
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