Cutaneous ulceration scattering induced topically by cannabidiol oil in the laboratory animal

Abstract

Introduction: There are few references on the effects of cannabis on the healing of skin lesions. Objectives: To verify the cicatricial evolution of cutaneous ulcers in the laboratory animal after topical application of cannabidiol oil (CBD). Methods: Experimental study with control group to verify the cicatricial influence of cannabidiol oil applied topically on experimental total skin ulcerative lesions in the adult male white rat, Sprague Dawley strain. Ten animals were used for each group (physiological saline, extra virgin olive oil (EVOO) and CBD) under standard laboratory conditions. After anesthesia with 100% isoflurane, a total skin wound was performed in the region of the back with a disposable surgical punch of 8 mm in diameter. Thereafter, 0.15 ml of the corresponding product is applied daily to the skin lesions. The healing process of cutaneous ulcerative lesions is carried out by means of the measurement and graphic recording of the contour of the lesions until tissue repair and definitive cutaneous closure occur. The statistical program SPSS 25.0 was used. Results: At the beginning of healing, the physiological serum is more procicant (p < 0.05). However, once the inflammatory phase of the lesion repair has been overcome, the group treated with CBD manages to heal in advance, followed by the group treated with EVOO, although there are no significant differences between the various groups of animals. Conclusions: There is a significant difference (p < 0.05) using physiological saline in the first days of tissue repair. The cannabidiol oil manages to heal in advance, at the end of the repair process, the ulcerative lesions compared to those treated with the other products used.