Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/73241
Campo DC Valoridioma
dc.contributor.authorRial Berriel, Cristian Javieren_US
dc.contributor.authorAcosta Dacal, Andrea Carolinaen_US
dc.contributor.authorZumbado Peña, Manuel Luisen_US
dc.contributor.authorPérez Luzardo, Octavio Luisen_US
dc.date.accessioned2020-06-12T11:43:23Z-
dc.date.available2020-06-12T11:43:23Z-
dc.date.issued2020en_US
dc.identifier.issn0048-9697en_US
dc.identifier.otherScopus-
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/73241-
dc.description.abstractThis work presents the optimization, validation, and verification of a miniaturized method for the determination of 360 environmental pollutants that are of toxicological concern for wildlife. The method implies a one-step QuEChERS-based extraction of 250 μl whole blood using acidified acetonitrile, followed by two complementary analyses by LC–MS/MS and GC–MS/MS. The optimized conditions allow the simultaneous determination of the major persistent organic pollutants, a wide range of plant protection products, rodenticides, pharmaceuticals, and a suite of metabolites that can be used as biomarkers of exposure. The method is very sensitive, and 95% of the pollutants can be detected at concentrations below 1.5 ng/ml. The method was applied to a series of 148 samples of nocturnal and diurnal wild raptors collected during field ecological studies in 2018 and 2019. Fifty-one different contaminants were found in these samples, with a median value of 7 contaminants per sample. As expected, five of the six contaminants that were detected in >50% of the samples were persistent or semi-persistent organic pollutants. However, it is striking the high frequency of detection of some non-persistent pollutants, such as 2-phenylphenol, benalaxyl, metaflumizone, diphenylamine, brodifacoum or levamisole, indicating the penetration of these chemicals into the food chains. The toxicological significance of all these findings should be studied in depth in future research. However, the results clearly demonstrated that the approach developed provides reliable, simple, and rapid determination of a wide range of pollutants in wildlife and makes it very useful to obtain valuable data in biomonitoring studies with only small amounts of sample.en_US
dc.languageengen_US
dc.relation.ispartofScience of the Total Environmenten_US
dc.sourceScience of the Total Environment [ISSN 0048-9697], v. 736, 139444, (Septiembre 2020)en_US
dc.subject3214 Toxicologíaen_US
dc.subject3105 Peces y fauna silvestreen_US
dc.subject310907 Patologíaen_US
dc.subject.otherMass Spectrometry-
dc.subject.otherPersistent Organic Pollutants-
dc.subject.otherPesticides-
dc.subject.otherPharmaceuticals-
dc.subject.otherRaptors-
dc.subject.otherRodenticides-
dc.titleMicro QuEChERS-based method for the simultaneous biomonitoring in whole blood of 360 toxicologically relevant pollutants for wildlifeen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.scitotenv.2020.139444en_US
dc.identifier.scopus85085559875-
dc.identifier.isi000542086100018-
dc.contributor.authorscopusid57206518403-
dc.contributor.authorscopusid56096659300-
dc.contributor.authorscopusid6603459604-
dc.contributor.authorscopusid6507534124-
dc.identifier.eissn1879-1026-
dc.relation.volume736en_US
dc.investigacionCiencias de la Salud-
dc.type2Artículoen_US
dc.contributor.daisngid5781369-
dc.contributor.daisngid13306269-
dc.contributor.daisngid30415411-
dc.contributor.daisngid418704-
dc.description.numberofpages20en_US
dc.utils.revision-
dc.contributor.wosstandardWOS:Rial-Berriel, C-
dc.contributor.wosstandardWOS:Acosta-Dacal, A-
dc.contributor.wosstandardWOS:Zumbado, M-
dc.contributor.wosstandardWOS:Luzardo, OP-
dc.date.coverdateSeptiembre 2020en_US
dc.identifier.ulpgces
dc.description.sjr1,795
dc.description.jcr7,963
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0003-2773-8075-
crisitem.author.orcid0000-0002-1272-0545-
crisitem.author.orcid0000-0002-1534-7758-
crisitem.author.orcid0000-0002-4153-3028-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRial Berriel, Cristian Javier-
crisitem.author.fullNameAcosta Dacal, Andrea Carolina-
crisitem.author.fullNameZumbado Peña, Manuel Luis-
crisitem.author.fullNamePérez Luzardo, Octavio Luis-
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