Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/70950
Título: Age-related risk factors for bacterial aetiology in community-acquired pneumonia
Autores/as: Sahuquillo-Arce, José M.
Menéndez, Rosario
Méndez, Raúl
Amara-Elori, Isabel
Zalacain, Rafael
Capelastegui, Alberto
Aspa, Javier
Borderías, Luis
Martín-Villasclaras, Juan J.
Bello, Salvador
Alfageme, Inmaculada
Rodríguez de Castro, Felipe Carlos B. 
Rello, Jordi
Molinos, Luis
Ruiz-Manzano, Juan
Torres, Antoni
Clasificación UNESCO: 3207 Patología
Palabras clave: Age
Community-acquired pneumonia
Comorbidities
Risk factors
Smoking and alcohol use
Fecha de publicación: 2016
Publicación seriada: Respirology 
Resumen: Background and objective: The objective of this study was to evaluate the effect of age and comorbidities, smoking and alcohol use on microorganisms in patients with community-acquired pneumonia (CAP). Methods: A prospective multicentre study was performed with 4304 patients. We compared microbiological results, bacterial aetiology, smoking, alcohol abuse and comorbidities in three age groups: young adults (<45 years), adults (45–64 years) and seniors (>65 years). Results: Bacterial aetiology was identified in 1522 (35.4%) patients. In seniors, liver disease was independently associated with Gram-negative bacteria (Haemophilus influenzae and Enterobacteriaceae), COPD with Pseudomonas aeruginosa (OR = 2.69 (1.46–4.97)) and Staphylococcus aureus (OR = 2.8 (1.24–6.3)) and neurological diseases with S. aureus. In adults, diabetes mellitus (DM) was a risk factor for Streptococcus pneumoniae and S. aureus, and COPD for H. influenzae (OR = 3.39 (1.06–10.83)). In young adults, DM was associated with S. aureus. Smoking was a risk factor for Legionella pneumophila regardless of age. Alcohol intake was associated with mixed aetiology and Coxiella burnetii in seniors, and with S. pneumoniae in young adults. Conclusion: It should be considered that the bacterial aetiology may differ according to the patient's age, comorbidities, smoking and alcohol abuse. More extensive microbiological testing is warranted in those with risk factors for infrequent microorganisms.
URI: http://hdl.handle.net/10553/70950
ISSN: 1323-7799
DOI: 10.1111/resp.12851
Fuente: Respirology [ISSN 1323-7799], v. 21 (8), p. 1472-1479
Colección:Artículos
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