Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/70881
DC Field | Value | Language |
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dc.contributor.author | Ferrando, Carlos | - |
dc.contributor.author | Soro, Marina | - |
dc.contributor.author | Unzueta, Carmen | - |
dc.contributor.author | Suarez-Sipmann, Fernando | - |
dc.contributor.author | Canet, Jaume | - |
dc.contributor.author | Librero, Julián | - |
dc.contributor.author | Pozo, Natividad | - |
dc.contributor.author | Peiró, Salvador | - |
dc.contributor.author | Llombart, Alicia | - |
dc.contributor.author | León, Irene | - |
dc.contributor.author | India, Inmaculada | - |
dc.contributor.author | Aldecoa, Cesar | - |
dc.contributor.author | Díaz-Cambronero, Oscar | - |
dc.contributor.author | Pestaña, David | - |
dc.contributor.author | Redondo, Francisco J. | - |
dc.contributor.author | Garutti, Ignacio | - |
dc.contributor.author | Balust, Jaume | - |
dc.contributor.author | García, Jose I. | - |
dc.contributor.author | Ibáñez, Maite | - |
dc.contributor.author | Granell, Manuel | - |
dc.contributor.author | Rodríguez Pérez, Aurelio Eduardo | - |
dc.contributor.author | Gallego, Lucía | - |
dc.contributor.author | de la Matta, Manuel | - |
dc.contributor.author | Brunelli, Andrea | - |
dc.contributor.author | Rovira, Lucas | - |
dc.contributor.author | Barrios, Francisco | - |
dc.contributor.author | Torres, Vicente | - |
dc.contributor.author | Hernández, Samuel | - |
dc.contributor.author | Gracia, Estefanía | - |
dc.contributor.author | Giné, Marta | - |
dc.contributor.author | García, María | - |
dc.contributor.author | García, Nuria | - |
dc.contributor.author | Miguel, Lisset | - |
dc.contributor.author | Sánchez, Sergio | - |
dc.contributor.author | Piñeiro, Patricia | - |
dc.contributor.author | Pujol, Roger | - |
dc.contributor.author | García-del-Valle, Santiago | - |
dc.contributor.author | Valdivia, José | - |
dc.contributor.author | Hernández, María J. | - |
dc.contributor.author | Padrón, Oto | - |
dc.contributor.author | Colás, Ana | - |
dc.contributor.author | Puig, Jaume | - |
dc.contributor.author | Azparren, Gonzalo | - |
dc.contributor.author | Tusman, Gerardo | - |
dc.contributor.author | Villar, Jesús | - |
dc.contributor.author | Belda, Javier | - |
dc.contributor.author | Acosta, Jesús | - |
dc.contributor.author | Aguilar, Gerardo | - |
dc.contributor.author | Alberola, María José | - |
dc.contributor.author | Alcón, Amalia | - |
dc.contributor.author | Alonso, Jose M. | - |
dc.contributor.author | Alonso, María Dolores | - |
dc.contributor.author | Anaya, Rafael | - |
dc.contributor.author | Argente, María Pilar | - |
dc.contributor.author | Agilaga, Marta | - |
dc.contributor.author | Arocas, Blanca | - |
dc.contributor.author | Asensio, Ana | - |
dc.contributor.author | Ayas, Begoña | - |
dc.contributor.author | Ayuso, Mercedes | - |
dc.contributor.author | Balandrón, Victor | - |
dc.contributor.author | Barrio, María | - |
dc.contributor.author | Bejarano, Natalia | - |
dc.contributor.author | Benítez, Inmaculada | - |
dc.contributor.author | Cabrera, Sergio | - |
dc.contributor.author | Carbonell, Jose A. | - |
dc.contributor.author | Carramiñana, Albert | - |
dc.contributor.author | Carrizo, Juan | - |
dc.contributor.author | Cegarra, Virginia | - |
dc.contributor.author | Chamorro, Estefanía | - |
dc.contributor.author | Charco, Pedro | - |
dc.contributor.author | Cruz, Patricia | - |
dc.contributor.author | Daviu, Francisco | - |
dc.contributor.author | De Fez, Mario | - |
dc.contributor.author | Del Río, Elena | - |
dc.contributor.author | Delgado, Carlos | - |
dc.contributor.author | Díaz, Ruben | - |
dc.contributor.author | Díaz, Susana | - |
dc.contributor.author | Díez, Fernando | - |
dc.contributor.author | Dosdá, Rosa | - |
dc.contributor.author | Duca, Alejandro | - |
dc.contributor.author | Etulain, Ma Justina | - |
dc.contributor.author | Fernández, Carmen | - |
dc.contributor.author | Franco, Tania | - |
dc.contributor.author | Fuentes, Isabel | - |
dc.contributor.author | Gallego, Clara | - |
dc.contributor.author | Gallego-Casilda, Alberto | - |
dc.contributor.author | Galve, Ana Isabel | - |
dc.contributor.author | Garcés, Cristina | - |
dc.contributor.author | García, Mercedes | - |
dc.contributor.author | Garrigues, Beatriz | - |
dc.contributor.author | Gilabert, Vicente | - |
dc.contributor.author | González, Domingo | - |
dc.contributor.author | Gutiérrez, Andrea | - |
dc.contributor.author | Hernández González, Inmaculada Servanda | - |
dc.contributor.author | Izquierdo, Ana | - |
dc.contributor.author | Jurado, Ana | - |
dc.contributor.author | González, Rafael | - |
dc.contributor.author | García, Javier | - |
dc.contributor.author | De Miguel, Ángeles | - |
dc.contributor.author | García, Pablo | - |
dc.date.accessioned | 2020-03-13T12:50:11Z | - |
dc.date.available | 2020-03-13T12:50:11Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2213-2600 | - |
dc.identifier.uri | http://hdl.handle.net/10553/70881 | - |
dc.description.abstract | Background: The effects of individualised perioperative lung-protective ventilation (based on the open-lung approach [OLA]) on postoperative complications is unknown. We aimed to investigate the effects of intraoperative and postoperative ventilatory management in patients scheduled for abdominal surgery, compared with standard protective ventilation. Methods: We did this prospective, multicentre, randomised controlled trial in 21 teaching hospitals in Spain. We enrolled patients who were aged 18 years or older, were scheduled to have abdominal surgery with an expected time of longer than 2 h, had intermediate-to-high-risk of developing postoperative pulmonary complications, and who had a body-mass index less than 35 kg/m2. Patients were randomly assigned (1:1:1:1) online to receive one of four lung-protective ventilation strategies using low tidal volume plus positive end-expiratory pressure (PEEP): open-lung approach (OLA)–iCPAP (individualised intraoperative ventilation [individualised PEEP after a lung recruitment manoeuvre] plus individualised postoperative continuous positive airway pressure [CPAP]), OLA–CPAP (intraoperative individualised ventilation plus postoperative CPAP), STD–CPAP (standard intraoperative ventilation plus postoperative CPAP), or STD–O2 (standard intraoperative ventilation plus standard postoperative oxygen therapy). Patients were masked to treatment allocation. Investigators were not masked in the operating and postoperative rooms; after 24 h, data were given to a second investigator who was masked to allocations. The primary outcome was a composite of pulmonary and systemic complications during the first 7 postoperative days. We did the primary analysis using the modified intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT02158923. Findings: Between Jan 2, 2015, and May 18, 2016, we enrolled 1012 eligible patients. Data were available for 967 patients, whom we included in the final analysis. Risk of pulmonary and systemic complications did not differ for patients in OLA–iCPAP (110 [46%] of 241, relative risk 0·89 [95% CI 0·74–1·07; p=0·25]), OLA–CPAP (111 [47%] of 238, 0·91 [0·76–1·09; p=0·35]), or STD–CPAP groups (118 [48%] of 244, 0·95 [0·80–1·14; p=0·65]) when compared with patients in the STD–O2 group (125 [51%] of 244). Intraoperatively, PEEP was increased in 69 (14%) of patients in the standard perioperative ventilation groups because of hypoxaemia, and no patients from either of the OLA groups required rescue manoeuvres. Interpretation: In patients who have major abdominal surgery, the different perioperative open lung approaches tested in this study did not reduce the risk of postoperative complications when compared with standard lung-protective mechanical ventilation. Funding: Instituto de Salud Carlos III of the Spanish Ministry of Economy and Competitiveness, and Grants Programme of the European Society of Anaesthesiology. | - |
dc.language | eng | - |
dc.relation.ispartof | The Lancet Respiratory Medicine | - |
dc.source | The Lancet Respiratory Medicine [ISSN 2213-2600], v. 6 (3), p. 193-203 | - |
dc.subject | 32 Ciencias médicas | - |
dc.subject | 3207 Patología | - |
dc.title | Individualised perioperative open-lung approach versus standard protective ventilation in abdominal surgery (iPROVE): a randomised controlled trial | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/S2213-2600(18)30024-9 | - |
dc.identifier.pmid | 6 | - |
dc.identifier.scopus | 2-s2.0-85040674622 | - |
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dc.description.lastpage | 203 | - |
dc.identifier.issue | 3 | - |
dc.description.firstpage | 193 | - |
dc.relation.volume | 6 | - |
dc.investigacion | Ciencias de la Salud | - |
dc.type2 | Artículo | - |
dc.utils.revision | Sí | - |
dc.identifier.ulpgc | Sí | es |
dc.description.sjr | 7,695 | |
dc.description.jcr | 22,992 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
item.fulltext | Sin texto completo | - |
item.grantfulltext | none | - |
crisitem.author.dept | GIR IUSA-ONEHEALTH 5: Reproducción Animal, Oncología y Anestesiología Comparadas | - |
crisitem.author.dept | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.dept | Departamento de Ciencias Médicas y Quirúrgicas | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.orcid | 0000-0003-0947-263X | - |
crisitem.author.orcid | 0000-0001-8937-9034 | - |
crisitem.author.parentorg | IU de Sanidad Animal y Seguridad Alimentaria | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Rodríguez Pérez, Aurelio Eduardo | - |
crisitem.author.fullName | Hernández González, Inmaculada Servanda | - |
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