Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/70881
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dc.contributor.authorFerrando, Carlos-
dc.contributor.authorSoro, Marina-
dc.contributor.authorUnzueta, Carmen-
dc.contributor.authorSuarez-Sipmann, Fernando-
dc.contributor.authorCanet, Jaume-
dc.contributor.authorLibrero, Julián-
dc.contributor.authorPozo, Natividad-
dc.contributor.authorPeiró, Salvador-
dc.contributor.authorLlombart, Alicia-
dc.contributor.authorLeón, Irene-
dc.contributor.authorIndia, Inmaculada-
dc.contributor.authorAldecoa, Cesar-
dc.contributor.authorDíaz-Cambronero, Oscar-
dc.contributor.authorPestaña, David-
dc.contributor.authorRedondo, Francisco J.-
dc.contributor.authorGarutti, Ignacio-
dc.contributor.authorBalust, Jaume-
dc.contributor.authorGarcía, Jose I.-
dc.contributor.authorIbáñez, Maite-
dc.contributor.authorGranell, Manuel-
dc.contributor.authorRodríguez Pérez, Aurelio Eduardo-
dc.contributor.authorGallego, Lucía-
dc.contributor.authorde la Matta, Manuel-
dc.contributor.authorBrunelli, Andrea-
dc.contributor.authorRovira, Lucas-
dc.contributor.authorBarrios, Francisco-
dc.contributor.authorTorres, Vicente-
dc.contributor.authorHernández, Samuel-
dc.contributor.authorGracia, Estefanía-
dc.contributor.authorGiné, Marta-
dc.contributor.authorGarcía, María-
dc.contributor.authorGarcía, Nuria-
dc.contributor.authorMiguel, Lisset-
dc.contributor.authorSánchez, Sergio-
dc.contributor.authorPiñeiro, Patricia-
dc.contributor.authorPujol, Roger-
dc.contributor.authorGarcía-del-Valle, Santiago-
dc.contributor.authorValdivia, José-
dc.contributor.authorHernández, María J.-
dc.contributor.authorPadrón, Oto-
dc.contributor.authorColás, Ana-
dc.contributor.authorPuig, Jaume-
dc.contributor.authorAzparren, Gonzalo-
dc.contributor.authorTusman, Gerardo-
dc.contributor.authorVillar, Jesús-
dc.contributor.authorBelda, Javier-
dc.contributor.authorAcosta, Jesús-
dc.contributor.authorAguilar, Gerardo-
dc.contributor.authorAlberola, María José-
dc.contributor.authorAlcón, Amalia-
dc.contributor.authorAlonso, Jose M.-
dc.contributor.authorAlonso, María Dolores-
dc.contributor.authorAnaya, Rafael-
dc.contributor.authorArgente, María Pilar-
dc.contributor.authorAgilaga, Marta-
dc.contributor.authorArocas, Blanca-
dc.contributor.authorAsensio, Ana-
dc.contributor.authorAyas, Begoña-
dc.contributor.authorAyuso, Mercedes-
dc.contributor.authorBalandrón, Victor-
dc.contributor.authorBarrio, María-
dc.contributor.authorBejarano, Natalia-
dc.contributor.authorBenítez, Inmaculada-
dc.contributor.authorCabrera, Sergio-
dc.contributor.authorCarbonell, Jose A.-
dc.contributor.authorCarramiñana, Albert-
dc.contributor.authorCarrizo, Juan-
dc.contributor.authorCegarra, Virginia-
dc.contributor.authorChamorro, Estefanía-
dc.contributor.authorCharco, Pedro-
dc.contributor.authorCruz, Patricia-
dc.contributor.authorDaviu, Francisco-
dc.contributor.authorDe Fez, Mario-
dc.contributor.authorDel Río, Elena-
dc.contributor.authorDelgado, Carlos-
dc.contributor.authorDíaz, Ruben-
dc.contributor.authorDíaz, Susana-
dc.contributor.authorDíez, Fernando-
dc.contributor.authorDosdá, Rosa-
dc.contributor.authorDuca, Alejandro-
dc.contributor.authorEtulain, Ma Justina-
dc.contributor.authorFernández, Carmen-
dc.contributor.authorFranco, Tania-
dc.contributor.authorFuentes, Isabel-
dc.contributor.authorGallego, Clara-
dc.contributor.authorGallego-Casilda, Alberto-
dc.contributor.authorGalve, Ana Isabel-
dc.contributor.authorGarcés, Cristina-
dc.contributor.authorGarcía, Mercedes-
dc.contributor.authorGarrigues, Beatriz-
dc.contributor.authorGilabert, Vicente-
dc.contributor.authorGonzález, Domingo-
dc.contributor.authorGutiérrez, Andrea-
dc.contributor.authorHernández González, Inmaculada Servanda-
dc.contributor.authorIzquierdo, Ana-
dc.contributor.authorJurado, Ana-
dc.contributor.authorGonzález, Rafael-
dc.contributor.authorGarcía, Javier-
dc.contributor.authorDe Miguel, Ángeles-
dc.contributor.authorGarcía, Pablo-
dc.date.accessioned2020-03-13T12:50:11Z-
dc.date.available2020-03-13T12:50:11Z-
dc.date.issued2018-
dc.identifier.issn2213-2600-
dc.identifier.urihttp://hdl.handle.net/10553/70881-
dc.description.abstractBackground: The effects of individualised perioperative lung-protective ventilation (based on the open-lung approach [OLA]) on postoperative complications is unknown. We aimed to investigate the effects of intraoperative and postoperative ventilatory management in patients scheduled for abdominal surgery, compared with standard protective ventilation. Methods: We did this prospective, multicentre, randomised controlled trial in 21 teaching hospitals in Spain. We enrolled patients who were aged 18 years or older, were scheduled to have abdominal surgery with an expected time of longer than 2 h, had intermediate-to-high-risk of developing postoperative pulmonary complications, and who had a body-mass index less than 35 kg/m2. Patients were randomly assigned (1:1:1:1) online to receive one of four lung-protective ventilation strategies using low tidal volume plus positive end-expiratory pressure (PEEP): open-lung approach (OLA)–iCPAP (individualised intraoperative ventilation [individualised PEEP after a lung recruitment manoeuvre] plus individualised postoperative continuous positive airway pressure [CPAP]), OLA–CPAP (intraoperative individualised ventilation plus postoperative CPAP), STD–CPAP (standard intraoperative ventilation plus postoperative CPAP), or STD–O2 (standard intraoperative ventilation plus standard postoperative oxygen therapy). Patients were masked to treatment allocation. Investigators were not masked in the operating and postoperative rooms; after 24 h, data were given to a second investigator who was masked to allocations. The primary outcome was a composite of pulmonary and systemic complications during the first 7 postoperative days. We did the primary analysis using the modified intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT02158923. Findings: Between Jan 2, 2015, and May 18, 2016, we enrolled 1012 eligible patients. Data were available for 967 patients, whom we included in the final analysis. Risk of pulmonary and systemic complications did not differ for patients in OLA–iCPAP (110 [46%] of 241, relative risk 0·89 [95% CI 0·74–1·07; p=0·25]), OLA–CPAP (111 [47%] of 238, 0·91 [0·76–1·09; p=0·35]), or STD–CPAP groups (118 [48%] of 244, 0·95 [0·80–1·14; p=0·65]) when compared with patients in the STD–O2 group (125 [51%] of 244). Intraoperatively, PEEP was increased in 69 (14%) of patients in the standard perioperative ventilation groups because of hypoxaemia, and no patients from either of the OLA groups required rescue manoeuvres. Interpretation: In patients who have major abdominal surgery, the different perioperative open lung approaches tested in this study did not reduce the risk of postoperative complications when compared with standard lung-protective mechanical ventilation. Funding: Instituto de Salud Carlos III of the Spanish Ministry of Economy and Competitiveness, and Grants Programme of the European Society of Anaesthesiology.-
dc.languageeng-
dc.relation.ispartofThe Lancet Respiratory Medicine-
dc.sourceThe Lancet Respiratory Medicine [ISSN 2213-2600], v. 6 (3), p. 193-203-
dc.subject32 Ciencias médicas-
dc.subject3207 Patología-
dc.titleIndividualised perioperative open-lung approach versus standard protective ventilation in abdominal surgery (iPROVE): a randomised controlled trial-
dc.typeinfo:eu-repo/semantics/article-
dc.typeArticle-
dc.identifier.doi10.1016/S2213-2600(18)30024-9-
dc.identifier.pmid6-
dc.identifier.scopus2-s2.0-85040674622-
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dc.description.lastpage203-
dc.identifier.issue3-
dc.description.firstpage193-
dc.relation.volume6-
dc.investigacionCiencias de la Salud-
dc.type2Artículo-
dc.utils.revision-
dc.identifier.ulpgces
dc.description.sjr7,695
dc.description.jcr22,992
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUSA-ONEHEALTH 5: Reproducción Animal, Oncología y Anestesiología Comparadas-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0003-0947-263X-
crisitem.author.orcid0000-0001-8937-9034-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez Pérez, Aurelio Eduardo-
crisitem.author.fullNameHernández González, Inmaculada Servanda-
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