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Title: Mitochondrial Complex I Inhibition by Metformin: Drug–Exercise Interactions
Authors: Martín Rodríguez, Saúl 
De Pablos Velasco, Pedro Luis 
López Calbet, José Antonio 
UNESCO Clasification: 32 Ciencias médicas
Keywords: Exercise
Mitochondrial Complex I
Issue Date: 2020
Journal: Trends in Endocrinology and Metabolism 
Abstract: Metformin has antidiabetic, anticancer, and prolongevity effects, but seems to interfere with aerobic training mitochondrial adaptations. The primary mechanism of action has been suggested to be the inhibition of mitochondrial complex I. Recent papers (Wang et al. and Cameron et al.), however, provide evidence to deny the hypothesis of a direct action of metformin on complex I.
ISSN: 1043-2760
DOI: 10.1016/j.tem.2020.02.003
Source: Trends in Endocrinology and Metabolism [ISSN 1043-2760]
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