|Title:||Mitochondrial Complex I Inhibition by Metformin: Drug–Exercise Interactions||Authors:||Martín Rodríguez, Saúl
De Pablos Velasco, Pedro Luis
López Calbet, José Antonio
|UNESCO Clasification:||32 Ciencias médicas||Keywords:||Exercise
Mitochondrial Complex I
|Issue Date:||2020||Journal:||Trends in Endocrinology and Metabolism||Abstract:||Metformin has antidiabetic, anticancer, and prolongevity effects, but seems to interfere with aerobic training mitochondrial adaptations. The primary mechanism of action has been suggested to be the inhibition of mitochondrial complex I. Recent papers (Wang et al. and Cameron et al.), however, provide evidence to deny the hypothesis of a direct action of metformin on complex I.||URI:||http://hdl.handle.net/10553/70757||ISSN:||1043-2760||DOI:||10.1016/j.tem.2020.02.003||Source:||Trends in Endocrinology and Metabolism [ISSN 1043-2760]|
|Appears in Collections:||Comentario|
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