Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/70652
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dc.contributor.authorLlàcer, Pauen_US
dc.contributor.authorNúñez, Julioen_US
dc.contributor.authorBayés-Genís, Antonien_US
dc.contributor.authorConde Martel, Aliciaen_US
dc.contributor.authorCabanes Hernández, Yolandaen_US
dc.contributor.authorDíez Manglano, Jesúsen_US
dc.contributor.authorÁlvarez Rocha, Pabloen_US
dc.contributor.authorSoler Rangel, Llanosen_US
dc.contributor.authorGómez Del Olmo, Vicenteen_US
dc.contributor.authorManzano, Luisen_US
dc.contributor.authorMontero Pérez-Barquero, Manuelen_US
dc.date.accessioned2020-03-05T09:10:17Z-
dc.date.available2020-03-05T09:10:17Z-
dc.date.issued2019en_US
dc.identifier.issn0953-6205en_US
dc.identifier.urihttp://hdl.handle.net/10553/70652-
dc.description.abstractBackground: The value of digoxin in heart failure (HF) remains controversial, particularly in patients with preserved ejection fraction (HFpEF). This study evaluated the 1-year risk of events after digoxin treatment for acute heart failure (AHF) in patients >70 years old with HFpEF. Methods: 1833 patients were included in this analysis (mean age, 82 years). The main endpoints were all-cause death and the composite of death and/or HF re-admission within 1 year. Cox regression analysis was used to evaluate the association between digoxin treatment and prognosis. Results: 401 patients received digoxin treatment; of these, 86% had atrial fibrillation. The mean baseline heart rate was 86 ± 22 bpm. At the 1-year follow-up, 375 patients (20.5%) died and 684 (37.3%) presented composite endpoints. Patients treated with digoxin showed higher rates of death (3.21 vs. 2.44 per 10 person-years, p = .019) and composite endpoint (6.72 vs. 5.18 per 10 person-years, p = .003). After multivariate adjustment, digoxin treatment remained associated with increased risks of death (HR = 1.46, 95% CI: 1.16–1.85, p = .001) and the composite endpoint (HR = 1.35, 95% CI: 1.13–1.61, p = .001). A distinctive prognostic effect of digoxin was found across the heart rate continuum; the risks for both endpoints were higher at lower heart rates and neutral at higher heart rates (p of the interactions = 0.007 and 0.03, respectively). Conclusions: In older patients with HFpEF discharged after AHF, digoxin treatment was associated with increased mortality and/or re-admission, particularly in patients with lower heart rates.en_US
dc.languageengen_US
dc.relation.ispartofEuropean Journal of Internal Medicineen_US
dc.sourceEuropean Journal of Internal Medicine [ISSN 0953-6205], n. 60, p. 18-23en_US
dc.subject3205 Medicina internaen_US
dc.subject.otherDigoxinen_US
dc.subject.otherHeart failureen_US
dc.subject.otherPrognosisen_US
dc.titleDigoxin and prognosis of heart failure in older patients with preserved ejection fraction: Importance of heart rate. Results from an observational and multicenter studyen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ejim.2018.10.010en_US
dc.identifier.pmid60-
dc.identifier.scopus2-s2.0-85055124649-
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dc.description.lastpage23en_US
dc.description.firstpage18en_US
dc.relation.volume60en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,017
dc.description.jcr4,329
dc.description.sjrqQ2
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-2540-3880-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameConde Martel, Alicia-
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