Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/70104
Campo DC Valoridioma
dc.contributor.authorRazquin, Cristinaen_US
dc.contributor.authorRuiz-Canela, Miguelen_US
dc.contributor.authorClish, Clary B.en_US
dc.contributor.authorLi, Junen_US
dc.contributor.authorToledo, Estefaniaen_US
dc.contributor.authorDennis, Courtneyen_US
dc.contributor.authorLiang, Limingen_US
dc.contributor.authorSalas-Huetos, Alberten_US
dc.contributor.authorPierce, Kerry A.en_US
dc.contributor.authorGuasch-Ferré, Martaen_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorEstruch, Ramonen_US
dc.contributor.authorGómez-Gracia, Enriqueen_US
dc.contributor.authorFitó, Montseen_US
dc.contributor.authorLapetra, Joseen_US
dc.contributor.authorRomaguera, Doraen_US
dc.contributor.authorAlonso-Gómez, Angelen_US
dc.contributor.authorSerra-Majem, Lluisen_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.contributor.authorHu, Frank B.en_US
dc.contributor.authorMartínez-González, Miguel A.en_US
dc.date.accessioned2020-02-05T12:52:26Z-
dc.date.available2020-02-05T12:52:26Z-
dc.date.issued2019en_US
dc.identifier.issn1475-2840en_US
dc.identifier.otherScopus-
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/70104-
dc.description.abstractBackground: The pandemic of cardiovascular disease (CVD) and type 2 diabetes (T2D) requires the identification of new predictor biomarkers. Biomarkers potentially modifiable with lifestyle changes deserve a special interest. Our aims were to analyze: (a) The associations of lysine, 2-aminoadipic acid (2-AAA) or pipecolic acid with the risk of T2D or CVD in the PREDIMED trial; (b) the effect of the dietary intervention on 1-year changes in these metabolites, and (c) whether the Mediterranean diet (MedDiet) interventions can modify the effects of these metabolites on CVD or T2D risk. Methods: Two unstratified case-cohort studies nested within the PREDIMED trial were used. For CVD analyses, we selected 696 non-cases and 221 incident CVD cases; for T2D, we included 610 non-cases and 243 type 2 diabetes incident cases. Metabolites were quantified using liquid chromatography-tandem mass spectrometry, at baseline and after 1-year of intervention. Results: In weighted Cox regression models, we found that baseline lysine (HR+1 SD increase = 1.26; 95% CI 1.06-1.51) and 2-AAA (HR+1 SD increase = 1.28; 95% CI 1.05-1.55) were both associated with a higher risk of T2D, but not with CVD. A significant interaction (p = 0.032) between baseline lysine and T2D on the risk of CVD was observed: subjects with prevalent T2D and high levels of lysine exhibited the highest risk of CVD. The intervention with MedDiet did not have a significant effect on 1-year changes of the metabolites. Conclusions: Our results provide an independent prospective replication of the association of 2-AAA with future risk of T2D. We show an association of lysine with subsequent CVD risk, which is apparently diabetes-dependent. No evidence of effects of MedDiet intervention on lysine, 2-AAA or pipecolic acid changes was found. Trial registration ISRCTN35739639; registration date: 05/10/2005; recruitment start date 01/10/2003en_US
dc.languageengen_US
dc.relation.ispartofCardiovascular Diabetologyen_US
dc.sourceCardiovascular Diabetology, [ISSN 1475-2840], v. 18 (1), (Noviembre 2019)en_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject320501 Cardiologíaen_US
dc.subject.otherBiomarkersen_US
dc.subject.otherCardiovascular Diseaseen_US
dc.subject.otherDietary Interventionen_US
dc.subject.otherMetabolitesen_US
dc.subject.otherType 2 Diabetesen_US
dc.titleLysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: Results from two case-cohort studiesen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12933-019-0958-2en_US
dc.identifier.scopus85074961499-
dc.identifier.isi000497753100001-
dc.contributor.authorscopusid13612519200-
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dc.contributor.authorscopusid55110459200-
dc.contributor.authorscopusid7003570538-
dc.contributor.authorscopusid35474202600-
dc.contributor.authorscopusid7005989830-
dc.contributor.authorscopusid57202571697-
dc.contributor.authorscopusid57206229124-
dc.contributor.authorscopusid6507771144-
dc.contributor.authorscopusid8161433300-
dc.contributor.authorscopusid7004308784-
dc.contributor.authorscopusid35596972100-
dc.contributor.authorscopusid57206277408-
dc.contributor.authorscopusid57208121316-
dc.contributor.authorscopusid56200287800-
dc.identifier.eissn1475-2840-
dc.identifier.issue1-
dc.relation.volume18en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
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dc.description.numberofpages12en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Razquin, C-
dc.contributor.wosstandardWOS:Ruiz-Canela, M-
dc.contributor.wosstandardWOS:Clish, CB-
dc.contributor.wosstandardWOS:Li, J-
dc.contributor.wosstandardWOS:Toledo, E-
dc.contributor.wosstandardWOS:Dennis, C-
dc.contributor.wosstandardWOS:Liang, LM-
dc.contributor.wosstandardWOS:Salas-Huetos, A-
dc.contributor.wosstandardWOS:Pierce, KA-
dc.contributor.wosstandardWOS:Guasch-Ferre, M-
dc.contributor.wosstandardWOS:Corella, D-
dc.contributor.wosstandardWOS:Ros, E-
dc.contributor.wosstandardWOS:Estruch, R-
dc.contributor.wosstandardWOS:Gomez-Gracia, E-
dc.contributor.wosstandardWOS:Fito, M-
dc.contributor.wosstandardWOS:Lapetra, J-
dc.contributor.wosstandardWOS:Romaguera, D-
dc.contributor.wosstandardWOS:Alonso-Gomez, A-
dc.contributor.wosstandardWOS:Serra-Majem, L-
dc.contributor.wosstandardWOS:Salas-Salvado, J-
dc.contributor.wosstandardWOS:Hu, FB-
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA-
dc.date.coverdateNoviembre 2019en_US
dc.identifier.ulpgces
dc.description.sjr2,172
dc.description.jcr7,332
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0002-9658-9061-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSerra Majem, Luis-
Colección:Artículos
miniatura
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