Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/70033
DC FieldValueLanguage
dc.contributor.authorAndrade, Fernando-
dc.contributor.authorVitoria, Isidro-
dc.contributor.authorMartín Hernández, Elena-
dc.contributor.authorPintos-Morell, Guillem-
dc.contributor.authorCorrecher, Patricia-
dc.contributor.authorPuig-Piña, Rocío-
dc.contributor.authorQuijada-Fraile, Pilar-
dc.contributor.authorPeña Quintana, Luis-
dc.contributor.authorMarquez, Ana Mª-
dc.contributor.authorVillate, Olatz-
dc.contributor.authorGarcía Silva, Mª Teresa-
dc.contributor.authorde las Heras, Javier-
dc.contributor.authorCeberio, Leticia-
dc.contributor.authorRodrigues, Esmeralda-
dc.contributor.authorAlmeida Campos, Teresa-
dc.contributor.authorYahyaoui, Raquel-
dc.contributor.authorBlasco, Javier-
dc.contributor.authorVives-Piñera, Inmaculada-
dc.contributor.authorGil, David-
dc.contributor.authordel Toro, Mireia-
dc.contributor.authorRuiz-Pons, Mónica-
dc.contributor.authorCañedo, Elvira-
dc.contributor.authorBarba Romero, Miguel Angel-
dc.contributor.authorGarcía-Jiménez, Mª Concepción-
dc.contributor.authorAldámiz-Echevarría, Luis-
dc.date.accessioned2020-02-05T12:52:01Z-
dc.date.available2020-02-05T12:52:01Z-
dc.date.issued2019-
dc.identifier.issn0731-7085-
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/70033-
dc.description.abstractPurpose: Salts of phenylacetic acid (PAA) and phenylbutyric acid (PBA) have been used for nitrogen elimination as a treatment for hyperammonaemia caused by urea cycle disorders (UCD). A new analytical method for PBA measurement in urine which helps to evaluate the drug adherence has been implemented. Methods: Urine specimens from UCD patients receiving PBA were analysed by tandem mass spectrometry to measure urine phenylacetylglutamine (PAGln). Some clinical and biochemical data for each patient were collected. Results: Our study included 87 samples from 40 UCD patients. The PAGln levels did not correlate with height, weight or age. However, the PAGln values showed correlation with PBA dose (r = 0.383, P = 0.015). Plasma glutamine and ammonia levels presented a positive correlation (r = 0.537, P < 0.001). The stability for PAGln in urine was determined at different storage temperatures. Conclusions: We have developed a simple method for the determination of PAGln in urine, which acts as useful biomarker of effective drug delivery. PAGln in urine is stable at room temperature at least for 15 days, and for several months when frozen at -20 °C. This procedure is useful for the optimization and monitorization of the drug dose allowing the use of spot urine samples.-
dc.languageeng-
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysis-
dc.sourceJournal of Pharmaceutical and Biomedical Analysis [ISSN 0731-7085], v. 176-
dc.subject32 Ciencias médicas-
dc.subject.otherBenzoic Acid-
dc.subject.otherHyperammonaemia-
dc.subject.otherPhenylbutyric Acid-
dc.subject.otherStability-
dc.subject.otherTandem Mass Spectrometry-
dc.subject.otherUrea Cycle Disorders-
dc.titleQuantification of urinary derivatives of Phenylbutyric and Benzoic acids by LC-MS/MS as treatment compliance biomarkers in Urea Cycle disorders-
dc.typeinfo:eu-repo/semantics/article-
dc.typeArticle-
dc.identifier.doi10.1016/j.jpba.2019.112798-
dc.identifier.scopus85072791910-
dc.identifier.isi000489000700013-
dc.contributor.authorscopusid14628260700-
dc.contributor.authorscopusid57202752915-
dc.contributor.authorscopusid6603425207-
dc.contributor.authorscopusid57204888203-
dc.contributor.authorscopusid57202744097-
dc.contributor.authorscopusid37662057500-
dc.contributor.authorscopusid36706618500-
dc.contributor.authorscopusid6603266503-
dc.contributor.authorscopusid57211144177-
dc.contributor.authorscopusid25958833800-
dc.contributor.authorscopusid57211144082-
dc.contributor.authorscopusid35739838900-
dc.contributor.authorscopusid55188561400-
dc.contributor.authorscopusid7102572626-
dc.contributor.authorscopusid55325603000-
dc.contributor.authorscopusid24367487400-
dc.contributor.authorscopusid7102318825-
dc.contributor.authorscopusid51562700400-
dc.contributor.authorscopusid55771644200-
dc.contributor.authorscopusid6603147916-
dc.contributor.authorscopusid16639901400-
dc.contributor.authorscopusid57205518361-
dc.contributor.authorscopusid6507778062-
dc.contributor.authorscopusid57211143517-
dc.contributor.authorscopusid6603581047-
dc.identifier.eissn1873-264X-
dc.relation.volume176-
dc.investigacionCiencias de la Salud-
dc.type2Artículo-
dc.contributor.daisngid29329977-
dc.contributor.daisngid31478977-
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dc.contributor.daisngid1176785-
dc.contributor.daisngid10092968-
dc.contributor.daisngid574176-
dc.description.numberofpages8-
dc.utils.revision-
dc.contributor.wosstandardWOS:Andrade, F-
dc.contributor.wosstandardWOS:Vitoria, I-
dc.contributor.wosstandardWOS:Hernandez, EM-
dc.contributor.wosstandardWOS:Pintos-Morell, G-
dc.contributor.wosstandardWOS:Correcher, P-
dc.contributor.wosstandardWOS:Puig-Pina, R-
dc.contributor.wosstandardWOS:Quijada-Fraile, P-
dc.contributor.wosstandardWOS:Pena-Quintana, L-
dc.contributor.wosstandardWOS:Marquez, AM-
dc.contributor.wosstandardWOS:Villate, O-
dc.contributor.wosstandardWOS:Silva, MTG-
dc.contributor.wosstandardWOS:de las Heras, J-
dc.contributor.wosstandardWOS:Ceberio, L-
dc.contributor.wosstandardWOS:Rodrigues, E-
dc.contributor.wosstandardWOS:Campos, TA-
dc.contributor.wosstandardWOS:Yahyaoui, R-
dc.contributor.wosstandardWOS:Blasco, J-
dc.contributor.wosstandardWOS:Vives-Pinera, I-
dc.contributor.wosstandardWOS:Gil, D-
dc.contributor.wosstandardWOS:del Toro, M-
dc.contributor.wosstandardWOS:Ruiz-Pons, M-
dc.contributor.wosstandardWOS:Canedo, E-
dc.contributor.wosstandardWOS:Romero, MAB-
dc.contributor.wosstandardWOS:Garcia-Jimenez, MC-
dc.contributor.wosstandardWOS:Aldamiz-Echevarria, L-
dc.date.coverdateNoviembre 2019-
dc.identifier.ulpgces
dc.description.sjr0,795
dc.description.jcr3,209
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0001-6052-5894-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNamePeña Quintana, Luis-
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