Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/69984
DC FieldValueLanguage
dc.contributor.authorMorchon Garcia,Rodrigoen_US
dc.contributor.authorCarretón Gomez, Elenaen_US
dc.contributor.authorGarcía, Ren_US
dc.contributor.authorZueva, T.en_US
dc.contributor.authorKartashev, V.en_US
dc.contributor.authorSimón, F.en_US
dc.date.accessioned2020-02-05T12:51:43Z-
dc.date.available2020-02-05T12:51:43Z-
dc.date.issued2020en_US
dc.identifier.issn0022-149Xen_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/69984-
dc.description.abstractHuman subcutaneous dirofilariosis has several clinical presentations. Many cases present as subcutaneous nodules, as a consequence of a local inflammatory reaction that encapsulates and destroys the worms. In addition, there are cases in which migrating worms located in the ocular area remain unencapsulated. In the present work, the levels of two pro-inflammatory eicosanoids, thromboxane B2 (TxB2) and leukotriene B4 (LTB4) are analysed by commercial Enzime-Linked immunosorbent assay (ELISA) in serum samples from 43 individuals, 28 diagnosed as having subcutaneous dirofilariasis presenting a subcutaneous nodule, five diagnosed as having dirofilariasis, in which the worms remained unencapsulated in the periphery of the eye, and ten healthy individuals living in a non-endemic area, used as controls. The worms were surgically removed, identifying Dirofilaria repens as the causative agent in all cases, by Polymerase Chain Reaction (PCR). Individuals with nodules showed significantly higher levels of TxB2 and LTB4 than healthy controls, whereas significant differences in LTB4 levels were observed between individuals with unencapsulated worms and healthy controls. It is speculated that the absence of LTB4 may contribute to the fact that worms remain unencapsulated as a part of immune evasion mechanisms.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Helminthologyen_US
dc.sourceJournal of Helminthology [ISSN 0022-149X], v. 94en_US
dc.subject320106 Dermatologíaen_US
dc.subject310907 Patologíaen_US
dc.subject.otherDirofilaria Repensen_US
dc.subject.otherEicosanoidsen_US
dc.subject.otherHumansen_US
dc.subject.otherLtb4en_US
dc.subject.otherSubcutaneous Dirofilariasisen_US
dc.subject.otherTxb2en_US
dc.titleA possible relationship between Thromboxane B2 and Leukotriene B4 and the encapsulation of Dirofilaria repens worms in human subcutaneous dirofilariasisen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1017/S0022149X19000464en_US
dc.identifier.scopus85069851469-
dc.contributor.authorscopusid6507293463-
dc.contributor.authorscopusid36143929200-
dc.contributor.authorscopusid57210196659-
dc.contributor.authorscopusid57209571819-
dc.contributor.authorscopusid36960834500-
dc.contributor.authorscopusid56098819600-
dc.relation.volume94en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgces
dc.description.sjr0,649
dc.description.jcr2,17
dc.description.sjrqQ1
dc.description.jcrqQ2
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR Medicina Veterinaria e Investigación Terapeútica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0001-6509-910X-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameMorchon Garcia, Rodrigo-
crisitem.author.fullNameCarretón Gómez, Elena-
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