Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/69917
DC FieldValueLanguage
dc.contributor.authorSánchez-Sarmiento, Angélica M.en_US
dc.contributor.authorCarvalho, Vitor L.en_US
dc.contributor.authorDiaz Delgado, Josueen_US
dc.contributor.authorRessio, Rodrigo A.en_US
dc.contributor.authorFernandes, Natália C.C.A.en_US
dc.contributor.authorGuerra, Juliana M.en_US
dc.contributor.authorSacristán, Carlosen_US
dc.contributor.authorGroch, Kátia R.en_US
dc.contributor.authorSilvestre-Perez, Nataliaen_US
dc.contributor.authorFerreira-Machado, Eduardoen_US
dc.contributor.authorCosta-Silva, Samiraen_US
dc.contributor.authorNavas-Suárez, Pedroen_US
dc.contributor.authorMeirelles, Ana C.O.en_US
dc.contributor.authorFavero, Cintiaen_US
dc.contributor.authorMarigo, Julianaen_US
dc.contributor.authorBertozzi, Carolina P.en_US
dc.contributor.authorColosio, Adriana C.en_US
dc.contributor.authorMarcondes, Milton C.C.en_US
dc.contributor.authorCremer, Marta J.en_US
dc.contributor.authordos Santos Silva, Nairléiaen_US
dc.contributor.authorFerreira Neto, Jose Soaresen_US
dc.contributor.authorKeid, Lara B.en_US
dc.contributor.authorSoares, Rodrigoen_US
dc.contributor.authorSierra Pulpillo, Eva Maríaen_US
dc.contributor.authorFernández Rodríguez, Antonio Jesúsen_US
dc.contributor.authorCatão-Dias, José L.en_US
dc.date.accessioned2020-02-05T12:51:16Z-
dc.date.available2020-02-05T12:51:16Z-
dc.date.issued2019en_US
dc.identifier.issn1865-1674en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/69917-
dc.description.abstractBrucella-exposure and infection is increasingly recognized in marine mammals worldwide. To better understand the epidemiology and health impacts of Brucella spp. in marine mammals of Brazil, molecular (conventional PCR and/or real-time PCR), serological (Rose Bengal Test [RBT], Competitive [c]ELISA, Serum Agglutination Test [SAT]), pathological, immunohistochemical (IHC) and/or microbiological investigations were conducted in samples of 129 stranded or by-caught marine mammals (orders Cetartiodactyla [n = 124], Carnivora [n = 4] and Sirenia [n = 1]). Previous serological tests performed on available sera of 27 of the 129 animals (26 cetaceans and one manatee), indicated 10 seropositive cetaceans. Conventional PCR and/or real-time PCR performed in cases with available organs (n = 119) and/or blood or swabs (n = 10) revealed 4/129 (3.1%) Brucella-infected cetaceans (one of them with positive serology; the remaining three with no available sera). Pathological, IHC and/or microbiological analyses conducted in PCR/real-time PCR and/or seropositive cases (n = 13) revealed Brucella-type lesions, including meningitis/meningoencephalitis, pneumonia, necrotizing hepatitis, pericarditis and osteoarthritis in some of those animals, and positive IHC was found in all of them (excepting two live-stranded animals without available organs). Brucella spp. culture attempts were unsuccessful. Our results demonstrated exposure, asymptomatic, acute and chronic Brucella sp. infection in several cetacean species in the Brazilian coast, highlighting the role of this pathogen in stranding and/or death, particularly in Clymene dolphin (Stenella clymene) and short-finned pilot whale (Globicephala macrorhynchus) off Ceará State. Novel hosts susceptible to Brucella included the franciscana (Pontoporia blainvillei), the Guiana dolphin (Sotalia guianensis) and the spinner dolphin (Stenella longirostris). Additionally, three coinfection cases involving Brucella spp. and cetacean morbillivirus, Edwarsiella tarda and Proteus mirabilis were detected. To the best of our knowledge, this is the first long-term and large-scale survey of Brucella spp. in marine mammals of South America, widening the spectrum of susceptible hosts and geographical distribution range of this agent with zoonotic potential.en_US
dc.languagespaen_US
dc.relation.ispartofTransboundary and Emerging Diseasesen_US
dc.sourceTransboundary and Emerging Diseases [ISSN 1865-1674], v. 66 (4), p. 1674-1692en_US
dc.subject3105 Peces y fauna silvestreen_US
dc.subject310907 Patologíaen_US
dc.subject.otherBrucella Spp.en_US
dc.subject.otherCetacean Morbillivirusen_US
dc.subject.otherCetacean Pathologyen_US
dc.subject.otherEdwarsiella Tardaen_US
dc.subject.otherImmunohistochemistryen_US
dc.subject.otherMarine Mammalsen_US
dc.subject.otherPcren_US
dc.subject.otherProteus Mirabilisen_US
dc.titleMolecular, serological, pathological, immunohistochemical and microbiological investigation of Brucella spp. in marine mammals of Brazil reveals new cetacean hostsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/tbed.13203
dc.identifier.scopus85066094677-
dc.identifier.isi000475513800025
dc.contributor.authorscopusid56520212100-
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dc.contributor.authorscopusid57212084410-
dc.contributor.authorscopusid6602455809-
dc.description.lastpage1692-
dc.identifier.issue4-
dc.description.firstpage1674-
dc.relation.volume66-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
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dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Sanchez-Sarmiento, AM
dc.contributor.wosstandardWOS:Carvalho, VL
dc.contributor.wosstandardWOS:Diaz-Delgado, J
dc.contributor.wosstandardWOS:Ressio, RA
dc.contributor.wosstandardWOS:Fernandes, NCCA
dc.contributor.wosstandardWOS:Guerra, JM
dc.contributor.wosstandardWOS:Sacristan, C
dc.contributor.wosstandardWOS:Groch, KR
dc.contributor.wosstandardWOS:Silvestre-Perez, N
dc.contributor.wosstandardWOS:Ferreira-Machado, E
dc.contributor.wosstandardWOS:Costa-Silva, S
dc.contributor.wosstandardWOS:Navas-Suarez, P
dc.contributor.wosstandardWOS:Meirelles, ACO
dc.contributor.wosstandardWOS:Favero, C
dc.contributor.wosstandardWOS:Marigo, J
dc.contributor.wosstandardWOS:Bertozzi, CP
dc.contributor.wosstandardWOS:Colosio, AC
dc.contributor.wosstandardWOS:Marcondes, MCC
dc.contributor.wosstandardWOS:Cremer, MJ
dc.contributor.wosstandardWOS:Silva, ND
dc.contributor.wosstandardWOS:Neto, JSF
dc.contributor.wosstandardWOS:Keid, LB
dc.contributor.wosstandardWOS:Soares, R
dc.contributor.wosstandardWOS:Sierra, E
dc.contributor.wosstandardWOS:Fernandez, A
dc.contributor.wosstandardWOS:Catao-Dias, JL
dc.date.coverdateJulio 2019
dc.identifier.ulpgces
dc.description.sjr1,514
dc.description.jcr4,188
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 3: Histología y Patología Veterinaria y Forense (Terrestre y Marina)-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.orcid0000-0003-1216-5446-
crisitem.author.orcid0000-0003-3749-8845-
crisitem.author.orcid0000-0001-5281-0521-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameDiaz Delgado,Josue-
crisitem.author.fullNameSierra Pulpillo, Eva María-
crisitem.author.fullNameFernández Rodríguez, Antonio Jesús-
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