Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/69910
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dc.contributor.authorPapandreou, Christopheren_US
dc.contributor.authorHernández-Alonso, Pabloen_US
dc.contributor.authorBulló, Mònicaen_US
dc.contributor.authorRuiz-Canela, Miguelen_US
dc.contributor.authorYu, Edwarden_US
dc.contributor.authorGuasch-Ferré, Martaen_US
dc.contributor.authorToledo, Estefaníaen_US
dc.contributor.authorDennis, Courtneyen_US
dc.contributor.authorDeik, Amyen_US
dc.contributor.authorClish, Claryen_US
dc.contributor.authorRazquin, Cristinaen_US
dc.contributor.authorCorella, Doloresen_US
dc.contributor.authorEstruch, Ramonen_US
dc.contributor.authorRos, Emilioen_US
dc.contributor.authorFitó, Montserraten_US
dc.contributor.authorArós, Fernandoen_US
dc.contributor.authorFiol, Miquelen_US
dc.contributor.authorLapetra, Joséen_US
dc.contributor.authorRuano Rodriguez, Cristinaen_US
dc.contributor.authorLiang, Limingen_US
dc.contributor.authorMartínez-González, Miguel A.en_US
dc.contributor.authorHu, Frank B.en_US
dc.contributor.authorSalas-Salvadó, Jordien_US
dc.date.accessioned2020-02-05T12:51:13Z-
dc.date.available2020-02-05T12:51:13Z-
dc.date.issued2019en_US
dc.identifier.issn2072-6643en_US
dc.identifier.otherScopus-
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/69910-
dc.description.abstractFew studies have examined the association of a wide range of metabolites with total and subtypes of coffee consumption. The aim of this study was to investigate associations of plasma metabolites with total, caffeinated, and decaffeinated coffee consumption. We also assessed the ability of metabolites to discriminate between coffee consumption categories. This is a cross-sectional analysis of 1664 participants from the PREDIMED study. Metabolites were semiquantitatively profiled using a multiplatform approach. Consumption of total coffee, caffeinated coffee and decaffeinated coffee was assessed by using a validated food frequency questionnaire. We assessed associations between 387 metabolite levels with total, caffeinated, or decaffeinated coffee consumption (≥50 mL coffee/day) using elastic net regression analysis. Ten-fold cross-validation analyses were used to estimate the discriminative accuracy of metabolites for total and subtypes of coffee. We identified different sets of metabolites associated with total coffee, caffeinated and decaffeinated coffee consumption. These metabolites consisted of lipid species (e.g., sphingomyelin, phosphatidylethanolamine, and phosphatidylcholine) or were derived from glycolysis (alpha-glycerophosphate) and polyphenol metabolism (hippurate). Other metabolites included caffeine, 5-acetylamino-6-amino-3-methyluracil, cotinine, kynurenic acid, glycocholate, lactate, and allantoin. The area under the curve (AUC) was 0.60 (95% CI 0.56-0.64), 0.78 (95% CI 0.75-0.81) and 0.52 (95% CI 0.49-0.55), in the multimetabolite model, for total, caffeinated, and decaffeinated coffee consumption, respectively. Our comprehensive metabolic analysis did not result in a new, reliable potential set of metabolites for coffee consumption.en_US
dc.languageengen_US
dc.relation.ispartofNutrientsen_US
dc.sourceNutrients [ISSN 2072-6643], v. 11 (5), (Mayo 2019)en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherCaffeineen_US
dc.subject.otherCoffeeen_US
dc.subject.otherMetabolomicsen_US
dc.subject.otherPlasmaen_US
dc.subject.otherPredimeden_US
dc.titlePlasma metabolites associated with coffee consumption: A metabolomic approach within the PREDIMED studyen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/nu11051032en_US
dc.identifier.scopus85065886222-
dc.identifier.isi000471021600092-
dc.contributor.authorscopusid36470858000-
dc.contributor.authorscopusid56239477300-
dc.contributor.authorscopusid57194127916-
dc.contributor.authorscopusid6603417884-
dc.contributor.authorscopusid56660312400-
dc.contributor.authorscopusid55110459200-
dc.contributor.authorscopusid7003562288-
dc.contributor.authorscopusid57130114700-
dc.contributor.authorscopusid54880256400-
dc.contributor.authorscopusid35460787900-
dc.contributor.authorscopusid13612519200-
dc.contributor.authorscopusid7003570538-
dc.contributor.authorscopusid7005989830-
dc.contributor.authorscopusid57202558933-
dc.contributor.authorscopusid57206229124-
dc.contributor.authorscopusid7004158382-
dc.contributor.authorscopusid7005315313-
dc.contributor.authorscopusid6507771144-
dc.contributor.authorscopusid57213005116-
dc.contributor.authorscopusid57204812694-
dc.contributor.authorscopusid7004290629-
dc.contributor.authorscopusid57208121316-
dc.contributor.authorscopusid7003357665-
dc.identifier.issue5-
dc.relation.volume11en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid1497982-
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dc.contributor.daisngid25605-
dc.description.numberofpages13en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Papandreou, C-
dc.contributor.wosstandardWOS:Hernandez-Alonso, P-
dc.contributor.wosstandardWOS:Bullo, M-
dc.contributor.wosstandardWOS:Ruiz-Canela, M-
dc.contributor.wosstandardWOS:Yu, E-
dc.contributor.wosstandardWOS:Guasch-Ferre, M-
dc.contributor.wosstandardWOS:Toledo, E-
dc.contributor.wosstandardWOS:Dennis, C-
dc.contributor.wosstandardWOS:Deik, A-
dc.contributor.wosstandardWOS:Clish, C-
dc.contributor.wosstandardWOS:Razquin, C-
dc.contributor.wosstandardWOS:Corella, D-
dc.contributor.wosstandardWOS:Estruch, R-
dc.contributor.wosstandardWOS:Ros, E-
dc.contributor.wosstandardWOS:Fito, M-
dc.contributor.wosstandardWOS:Aros, F-
dc.contributor.wosstandardWOS:Fiol, M-
dc.contributor.wosstandardWOS:Lapetra, J-
dc.contributor.wosstandardWOS:Ruano, C-
dc.contributor.wosstandardWOS:Liang, LM-
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA-
dc.contributor.wosstandardWOS:Hu, FB-
dc.contributor.wosstandardWOS:Salas-Salvado, J-
dc.date.coverdateMayo 2019en_US
dc.identifier.ulpgces
dc.description.sjr1,329
dc.description.jcr4,546
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Didácticas Específicas-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRuano Rodriguez, Cristina-
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