Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/69818
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dc.contributor.authorRodríguez-Esparragón, Franciscoen_US
dc.contributor.authorMarrero-Robayna, Silviaen_US
dc.contributor.authorGonzález-Cabrera, Faynaen_US
dc.contributor.authorHernández-Trujillo, Yaridéen_US
dc.contributor.authorBuset-Ríos, Nisaen_US
dc.contributor.authorRodríguez-Pérez, José Carlosen_US
dc.contributor.authorVega-Díaz, Nicanoren_US
dc.date.accessioned2020-02-05T12:50:20Z-
dc.date.available2020-02-05T12:50:20Z-
dc.date.issued2018en_US
dc.identifier.issn2048-8505en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/69818-
dc.description.abstractBackground. We have compared the effects of conventional lactate-based peritoneal dialysis fluid (CPDF) with respect to bicarbonate/lactate-based fluid on peritoneal ultrafiltration (UF) and peritoneal permeability, and on variations on gene expression in cells isolated from effluents of patients' peritoneal bags. Methods. This was a non-randomized sequential prospective study including all incident peritoneal dialysis (PD) patients (n ¼ 40) recruited in our centre. Peritoneal equilibration tests (PETs) were performed using CPDF or BPDF both containing 2.27% glucose during a 48-h interval in four different sequences. Gene expression variation of selected genes was measured by reverse transcription polymerase chain reaction in mesothelial cells obtained from the total drained fluid during the PET. Results. In the overall study, the use of BPDF was associated with significantly lower mass transfer area coefficient for urea and creatinine, longer accelerated peritoneal examination test times for urea and creatinine, lower total pore area available for exchange over diffusion distance and lower UF. There were no differences in the gene expression of aquaporins 1-3, endothelial and inducible nitric oxide synthase (NOS3 and NOS2), or interleukin-6. The SNAIL and E-CADHERIN gene expression normalized ratio was evaluated in peritoneal effluents of cells obtained from CPDF and BPDF. We observed that the SNAIL/E-CADHERIN mRNA ratio decreased when the dialysis sequence started with BPDF and went on to CPDF, but not when the sequence was the opposite. Conclusion. This study shows that those patients who started PD treatment with BPDF were characterized by a better biocompatibility profile. BPDF associates with lower peritoneal permeability to small molecules and lower UF.en_US
dc.languagespaen_US
dc.relation.ispartofCKJ: Clinical Kidney Journalen_US
dc.sourceClinical Kidney Journa l[ISSN 2048-8505], v. 11 (6), p. 881-888en_US
dc.subject320506 Nefrologíaen_US
dc.subject.otherBicarbonate/Lactate Buffered Solutionen_US
dc.subject.otherBiocompatibilityen_US
dc.subject.otherEpithelial-To-Mesenchymal Transitionen_US
dc.subject.otherMesothelial Cellsen_US
dc.subject.otherPeritoneal Dialysisen_US
dc.subject.otherPeritoneal Transport Rateen_US
dc.titlePeritoneal dialysis fluid biocompatibility impact on human peritoneal membrane permeabilityen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/ckj/sfy043
dc.identifier.scopus85062043910-
dc.identifier.isi000454501100019
dc.contributor.authorscopusid6603262370-
dc.contributor.authorscopusid55443664600-
dc.contributor.authorscopusid12771664100-
dc.contributor.authorscopusid8758145300-
dc.contributor.authorscopusid34970818700-
dc.contributor.authorscopusid7005446255-
dc.contributor.authorscopusid6507084608-
dc.description.lastpage888-
dc.identifier.issue6-
dc.description.firstpage881-
dc.relation.volume11-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid1305938
dc.contributor.daisngid7027809
dc.contributor.daisngid5539868
dc.contributor.daisngid5660229
dc.contributor.daisngid9299806
dc.contributor.daisngid4337946
dc.contributor.daisngid5807597
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Rodriguez-Esparragon, F
dc.contributor.wosstandardWOS:Marrero-Robayna, S
dc.contributor.wosstandardWOS:Gonzalez-Cabrera, F
dc.contributor.wosstandardWOS:Hernandez-Trujillo, Y
dc.contributor.wosstandardWOS:Buset-Rios, N
dc.contributor.wosstandardWOS:Rodriguez-Perez, JC
dc.contributor.wosstandardWOS:Vega-Diaz, N
dc.date.coverdateDiciembre 2018
dc.identifier.ulpgces
dc.description.sjr1,092
dc.description.jcr2,975
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR Patología médica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0003-1663-3673-
crisitem.author.orcid0000-0003-0023-1063-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameRodríguez Esparragón, Francisco Javier-
crisitem.author.fullNameRodríguez Pérez, José Carlos-
crisitem.author.fullNameVega Díaz, Nicanor Jesús-
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