Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/69816
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Recio Cruz, Carlota Pilar | en_US |
dc.contributor.author | Guerra, Borja | en_US |
dc.contributor.author | Guerra Rodríguez, Miguel Alfonso | en_US |
dc.contributor.author | Aranda Tavío, Haidee Magdalena | en_US |
dc.contributor.author | Martín-Rodríguez, Patricia | en_US |
dc.contributor.author | de Mirecki-Garrido, Mercedes | en_US |
dc.contributor.author | Brito-Casillas, Yeray | en_US |
dc.contributor.author | García-Castellano, José M. | en_US |
dc.contributor.author | Estévez-Braun, Ana | en_US |
dc.contributor.author | Fernández Pérez, Leandro Fco | en_US |
dc.date.accessioned | 2020-02-05T12:50:20Z | - |
dc.date.available | 2020-02-05T12:50:20Z | - |
dc.date.issued | 2019 | en_US |
dc.identifier.issn | 0950-9232 | en_US |
dc.identifier.other | Scopus | - |
dc.identifier.uri | http://hdl.handle.net/10553/69816 | - |
dc.description.abstract | The signal transducer and activator of transcription (STAT) are transcription factors that work via JAK/STAT pathway regulating the expression of genes involved in cell survival, proliferation, differentiation, development, immune response, and, among other essential biological functions, hematopoiesis. JAK/STAT signaling is strictly regulated under normal physiological conditions. However, a large group of diverse diseases has been associated to an aberrant regulation of STAT factors. Erroneous modulation of the pathway leads to constitutive STAT activation, thereby driving proliferation, inflammation, and an uncontrolled immune response. Deregulated STAT5 activation has been found in the development of many hematopoietic tumors, including chronic and acute leukemias, polycythemia vera, and lymphoma. Mutations in the kinases that phosphorylate STAT5, and/or overexpression of the upstream receptor-associated tyrosine kinases have been suggested as the main drivers of constitutive STAT5 activation. Hyper-activated STAT5 leads to the aberrant expression of its target genes including antiapoptotic, proliferative, and pro-inflammatory genes, favouring tumorigenesis. In this review, we intent to discuss the biology of JAK/STAT pathway, with particular focus on STAT5 and its crucial role in the development and progression of hematologic malignancies. Furthermore, we provide a synopsis of potential therapeutic strategies based on STAT5 activity inhibition that may represent an excellent opportunity for drug development in oncohematology. | en_US |
dc.language | eng | en_US |
dc.relation | Desarrollo Preclínico de Nuevas Estructuras Bioactivas Moduladoras de Las Actividades Oncogénicas de Stat3/5 O de Los Receptores de Estrógenos | en_US |
dc.relation.ispartof | Oncogene | en_US |
dc.source | Oncogene [ISSN 0950-9232], v. 38 (24), p. 4657-4668 | en_US |
dc.subject | 320101 Oncología | en_US |
dc.subject | 3207 Patología | en_US |
dc.subject.other | Chronic Myeloid-Leukemia | en_US |
dc.subject.other | Hodgkin Lymphoma | en_US |
dc.subject.other | Janus Kinases | en_US |
dc.subject.other | Stat Proteins | en_US |
dc.subject.other | Self-Renewal | en_US |
dc.subject.other | Bcr-Abl | en_US |
dc.subject.other | Cells | en_US |
dc.subject.other | Imatinib | en_US |
dc.subject.other | Mutation | en_US |
dc.subject.other | Pathway | en_US |
dc.title | Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/s41388-019-0752-3 | en_US |
dc.identifier.scopus | 85061924422 | - |
dc.identifier.isi | 000471160500001 | - |
dc.contributor.authorscopusid | 55354079200 | - |
dc.contributor.authorscopusid | 7006442271 | - |
dc.contributor.authorscopusid | 57206720991 | - |
dc.contributor.authorscopusid | 57206731335 | - |
dc.contributor.authorscopusid | 36604772400 | - |
dc.contributor.authorscopusid | 57206729085 | - |
dc.contributor.authorscopusid | 56236021400 | - |
dc.contributor.authorscopusid | 6602732739 | - |
dc.contributor.authorscopusid | 6701825073 | - |
dc.contributor.authorscopusid | 6506777525 | - |
dc.description.lastpage | 4668 | en_US |
dc.identifier.issue | 24 | - |
dc.description.firstpage | 4657 | en_US |
dc.relation.volume | 38 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.contributor.daisngid | 1999350 | - |
dc.contributor.daisngid | 909211 | - |
dc.contributor.daisngid | 29589749 | - |
dc.contributor.daisngid | 13167518 | - |
dc.contributor.daisngid | 3922169 | - |
dc.contributor.daisngid | 4588303 | - |
dc.contributor.daisngid | 3255019 | - |
dc.contributor.daisngid | 2034496 | - |
dc.contributor.daisngid | 425077 | - |
dc.contributor.daisngid | 30259663 | - |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Recio, C | - |
dc.contributor.wosstandard | WOS:Guerra, B | - |
dc.contributor.wosstandard | WOS:Guerra-Rodriguez, M | - |
dc.contributor.wosstandard | WOS:Aranda-Tavio, H | - |
dc.contributor.wosstandard | WOS:Martin-Rodriguez, P | - |
dc.contributor.wosstandard | WOS:de Mirecki-Garrido, M | - |
dc.contributor.wosstandard | WOS:Brito-Casillas, Y | - |
dc.contributor.wosstandard | WOS:Garcia-Castellano, JM | - |
dc.contributor.wosstandard | WOS:Estevez-Braun, A | - |
dc.contributor.wosstandard | WOS:Fernandez-Perez, L | - |
dc.date.coverdate | Junio 2019 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.sjr | 3,232 | |
dc.description.jcr | 7,971 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
item.fulltext | Sin texto completo | - |
item.grantfulltext | none | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Morfología | - |
crisitem.author.dept | GIR IUIBS: Diabetes y endocrinología aplicada | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | GIR IUIBS: Farmacología Molecular y Traslacional | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.orcid | 0000-0002-8832-2826 | - |
crisitem.author.orcid | 0000-0003-4355-5682 | - |
crisitem.author.orcid | 0000-0002-0047-1131 | - |
crisitem.author.orcid | 0000-0002-0559-9097 | - |
crisitem.author.orcid | 0000-0002-2378-3242 | - |
crisitem.author.orcid | 0000-0003-0488-6307 | - |
crisitem.author.orcid | 0000-0002-0707-7444 | - |
crisitem.author.orcid | 0000-0001-7802-465X | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Recio Cruz, Carlota Pilar | - |
crisitem.author.fullName | Guerra Hernández, Carlos Borja | - |
crisitem.author.fullName | Guerra Rodríguez, Miguel Alfonso | - |
crisitem.author.fullName | Aranda Tavío, Haidée Magdalena | - |
crisitem.author.fullName | Martín Rodríguez, Patricia | - |
crisitem.author.fullName | De Mirecki Garrido, Mercedes | - |
crisitem.author.fullName | Brito Casillas, Yeray | - |
crisitem.author.fullName | Fernández Pérez, Leandro Francisco | - |
crisitem.project.principalinvestigator | Fernández Pérez, Leandro Francisco | - |
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