Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/6561
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dc.contributor.authorWagner, P.D.
dc.contributor.authorAraoz, M.
dc.contributor.authorBoushel, R.
dc.contributor.authorCalbet, JAL
dc.contributor.authorJessen, Birguitte
dc.contributor.authorRadegran, Goran
dc.contributor.authorSpielvogel, Hilde
dc.contributor.authorSondergaard, H.
dc.contributor.authorWagner, Harrieth
dc.contributor.authorSaltin, Bengt
dc.contributor.otherCalbet, Jose A
dc.date.accessioned2011-10-31T02:31:00Z
dc.date.accessioned2018-03-08T09:04:31Z-
dc.date.available2011-10-31T13:24:12Z
dc.date.available2018-03-08T09:04:31Z-
dc.date.issued2002
dc.identifier.issn8750-7587
dc.identifier.urihttp://hdl.handle.net/10553/6561
dc.description.abstract Pulmonary gas exchange and acid-base state were compared in nine Danish lowlanders (L) acclimatized to 5,260 m for 9 wk and seven native Bolivian residents (N) of La Paz (altitude 3,600-4,100 m) brought acutely to this altitude. We evaluated normalcy of arterial pH and assessed pulmonary gas exchange and acid-base balance at rest and during peak exercise when breathing room air and 55% O2. Despite 9 wk at 5,260 m and considerable renal bicarbonate excretion (arterial plasma HCO3- concentration = 15.1 meq/l), resting arterial pH in L was 7.48 +/- 0.007 (significantly greater than 7.40). On the other hand, arterial pH in N was only 7.43 +/- 0.004 (despite arterial O2 saturation of 77%) after ascent from 3,600-4,100 to 5,260 m in 2 h. Maximal power output was similar in the two groups breathing air, whereas on 55% O2 only L showed a significant increase. During exercise in air, arterial PCO2 was 8 Torr lower in L than in N (P < 0.001), yet PO2 was the same such that, at maximal O2 uptake, alveolar-arterial PO2 difference was lower in N (5.3 +/- 1.3 Torr) than in L (10.5 +/- 0.8 Torr), P = 0.004. Calculated O2 diffusing capacity was 40% higher in N than in L and, if referenced to maximal hyperoxic work, capacity was 73% greater in N. Buffering of lactic acid was greater in N, with 20% less increase in base deficit per millimole per liter rise in lactate. These data show in L persistent alkalosis even after 9 wk at 5,260 m. In N, the data show 1) insignificant reduction in exercise capacity when breathing air at 5,260 m compared with breathing 55% O2; 2) very little ventilatory response to acute hypoxemia (judged by arterial pH and arterial PCO2 responses to hyperoxia); 3) during exercise, greater pulmonary diffusing capacity than in L, allowing maintenance of arterial PO2 despite lower ventilation; and 4) better buffering of lactic acid. These results support and extend similar observations concerning adaptation in lung function in these and other high-altitude native groups previously performed at much lower altitudes.es
dc.languageenges
dc.relation.ispartofJournal of Applied Physiologyes-ES
dc.sourceJournal Of Applied Physiology[ISSN 8750-7587],v. 92 (4), p. 1393-1400es
dc.subject241106 Fisiología del ejercicioes
dc.subject.otherHypoxiaes
dc.subject.otherCardiac outputes
dc.subject.otherVO2maxes
dc.subject.otherAltitudees
dc.subject.otherExercisees
dc.titlePulmonary gas exchange and acid-base state at 5,260 m in high-altitude Bolivians and acclimatized lowlanderses
dc.typeinfo:eu-repo/semantics/articlees
dc.typeinfo:eu-repo/semantics/articlees
dc.typeArticlees
dc.identifier.doi10.1152/japplphysiol.00093.2001
dc.identifier.scopus2-s2.0-0036095538-
dc.identifier.isi000174572600007
dcterms.isPartOfJournal Of Applied Physiology
dcterms.sourceJournal Of Applied Physiology[ISSN 8750-7587],v. 92 (4), p. 1393-1400
dc.identifier.crisid-;-;-;475;-;-;-;-;-;-
dc.description.lastpage1400
dc.description.firstpage1393
dc.relation.volume92
dc.investigacionCiencias de la Saludes
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.type2Artículoes
dc.identifier.wosWOS:000174572600007-
dc.contributor.daisngid8464
dc.contributor.daisngid23307769
dc.contributor.daisngid220476
dc.contributor.daisngid90295
dc.contributor.daisngid7243568
dc.contributor.daisngid328369
dc.contributor.daisngid284726
dc.contributor.daisngid14662296
dc.contributor.daisngid729625
dc.contributor.daisngid13919
dc.identifier.investigatorRIDH-6693-2015
dc.identifier.ulpgces
dc.description.jcr2,72
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Educación Física-
crisitem.author.orcid0000-0002-9215-6234-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameLópez Calbet, José Antonio-
Colección:Artículos
miniatura
Pulmonary gas exchange and acid-base state at 5,260 m in high-altitude Bolivians and acclimatized lowlanders
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