Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/6552
Campo DC Valoridioma
dc.contributor.authorLundby, Carsten-
dc.contributor.authorThomsen, J.-
dc.contributor.authorBoushel, R.-
dc.contributor.authorKoskolou, Maria D.-
dc.contributor.authorWarberg, Jorgen-
dc.contributor.authorCalbet, Jose A. L.-
dc.contributor.authorRobach, Paul-
dc.contributor.otherCalbet, Jose A
dc.date.accessioned2011-10-31T02:31:00Z-
dc.date.accessioned2018-03-08T13:10:33Z-
dc.date.available2011-10-31T09:41:45Z-
dc.date.available2018-03-08T13:10:33Z-
dc.date.issued2007-
dc.identifier.issn0022-3751-
dc.identifier.urihttp://hdl.handle.net/10553/6552-
dc.description.abstractErythropoietin (Epo) has been suggested to affect plasma volume, and would thereby possess a mechanism apart from erythropoiesis to increase arterial oxygen content. This, and potential underlying mechanisms, were tested in eight healthy subjects receiving 5000 IU recombinant human Epo (rHuEpo) for 15 weeks at a dose frequency aimed to increase and maintain haematocrit at approximately 50%. Red blood cell volume was increased from 2933 +/- 402 ml before rHuEpo treatment to 3210 +/- 356 (P < 0.01), 3117 +/- 554 (P < 0.05), and 3172 +/- 561 ml (P < 0.01) after 5, 11 and 13 weeks, respectively. This was accompanied by a decrease in plasma volume from 3645 +/- 538 ml before rHuEpo treatment to 3267 +/- 333 (P < 0.01), 3119 +/- 499 (P < 0.05), and 3323 +/- 521 ml (P < 0.01) after 5, 11 and 13 weeks, respectively. Concomitantly, plasma renin activity and aldosterone concentration were reduced. This maintained blood volume relatively unchanged, with a slight transient decrease at week 11, such that blood volume was 6578 +/- 839 ml before rHuEpo treatment, and 6477 +/- 573 (NS), 6236 +/- 908 (P < 0.05), and 6495 +/- 935 ml (NS), after 5, 11 and 13 weeks of treatment. We conclude that Epo treatment in healthy humans induces an elevation in haemoglobin concentration by two mechanisms: (i) an increase in red cell volume; and (ii) a decrease in plasma volume, which is probably mediated by a downregulation of the rennin-angiotensin-aldosterone axis. Since the relative contribution of plasma volume changes to the increments in arterial oxygen content was between 37.9 and 53.9% during the study period, this mechanism seems as important for increasing arterial oxygen content as the well-known erythropoietic effect of Epo.en
dc.languageenges
dc.relation.ispartofJournal of Physiologyes-ES
dc.sourceJournal Of Physiology-London[ISSN 0022-3751],v. 578 (1), p. 309-314es
dc.subject241106 Fisiología del ejercicioes
dc.subject.otherAdultses
dc.subject.otherAldosteronees
dc.subject.otherErythropoietines
dc.subject.otherHemoglobines
dc.subject.otherBloodes
dc.titleErythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volumees
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1113/jphysiol.2006.122689
dc.identifier.scopus33845796987-
dc.identifier.isi000243296900026
dcterms.isPartOfJournal Of Physiology-London
dcterms.sourceJournal Of Physiology-London[ISSN 0022-3751],v. 578 (1), p. 309-314
dc.contributor.authorscopusid57203056925
dc.contributor.authorscopusid14631433200
dc.contributor.authorscopusid7003471688
dc.contributor.authorscopusid6507527910
dc.contributor.authorscopusid7007049508
dc.contributor.authorscopusid7004323423
dc.contributor.authorscopusid6603355287
dc.identifier.crisid475-
dc.identifier.eissn1469-7793-
dc.description.lastpage314
dc.description.firstpage309
dc.relation.volume578
dc.investigacionCiencias de la Saludes
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.type2Artículoes
dc.identifier.wosWOS:000243296900026-
dc.contributor.daisngid95120
dc.contributor.daisngid2695244
dc.contributor.daisngid220476
dc.contributor.daisngid1492293
dc.contributor.daisngid28137233
dc.contributor.daisngid90295
dc.contributor.daisngid450826
dc.identifier.investigatorRIDH-6693-2015
dc.contributor.wosstandardWOS:Lundby, C
dc.contributor.wosstandardWOS:Thomsen, JJ
dc.contributor.wosstandardWOS:Boushel, R
dc.contributor.wosstandardWOS:Koskolou, M
dc.contributor.wosstandardWOS:Warberg, J
dc.contributor.wosstandardWOS:Calbet, JAL
dc.contributor.wosstandardWOS:Robach, P
dc.date.coverdateEnero 2007
dc.identifier.ulpgces
dc.description.jcr4,58
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Educación Física-
crisitem.author.orcid0000-0002-9215-6234-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameLópez Calbet, José Antonio-
Colección:Artículos
miniatura
Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume
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