Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/6547
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dc.contributor.authorCalbet, José A L-
dc.contributor.otherCalbet, Jose A
dc.date.accessioned2011-10-31T02:31:00Z-
dc.date.accessioned2018-03-08T13:11:33Z-
dc.date.available2011-10-31T08:43:27Z-
dc.date.available2018-03-08T13:11:33Z-
dc.date.issued2003-
dc.identifier.issn0022-3751-
dc.identifier.urihttp://hdl.handle.net/10553/6547-
dc.description.abstractChronic hypoxia is associated with elevated sympathetic activity and hypertension in patients with chronic pulmonary obstructive disease. However, the effect of chronic hypoxia on systemic and regional sympathetic activity in healthy humans remains unknown. To determine if chronic hypoxia in healthy humans is associated with hyperactivity of the sympathetic system, we measured intra-arterial blood pressure, arterial blood gases, systemic and skeletal muscle noradrenaline (norepinephrine) spillover and vascular conductances in nine Danish lowlanders at sea level and after 9 weeks of exposure at 5260 m. Mean blood pressure was 28 % higher at altitude (P < 0.01) due to increases in both systolic (18 % higher, P < 0.05) and diastolic (41 % higher, P < 0.001) blood pressures. Cardiac output and leg blood flow were not altered by chronic hypoxia, but systemic vascular conductance was reduced by 30 % (P < 0.05). Plasma arterial noradrenaline (NA) and adrenaline concentrations were 3.7- and 2.4-fold higher at altitude, respectively (P < 0.05). The elevation of plasma arterial NA concentration was caused by a 3.8-fold higher whole-body NA release (P < 0.001) since whole-body noradrenaline clearance was similar in both conditions. Leg NA spillover was increased similarly (x 3.2, P < 0.05). These changes occurred despite the fact that systemic O2 delivery was greater after altitude acclimatisation than at sea level, due to 37 % higher blood haemoglobin concentration. In summary, this study shows that chronic hypoxia causes marked activation of the sympathetic nervous system in healthy humans and increased systemic arterial pressure, despite normalisation of the arterial O2 content with acclimatisation.es
dc.languageenges
dc.relation.ispartofJournal of Physiologyes-ES
dc.sourceJournal of Physiology[ISSN 0022-3751],v. 551, p. 379-386es
dc.subject241106 Fisiología del ejercicioes
dc.subject.otherHypoxiaes
dc.subject.otherBlood pressurees
dc.subject.otherAdrenalinees
dc.subject.otherNoradrenalinees
dc.titleChronic hypoxia increases blood pressure and noradrenaline spillover in healthy humanses
dc.typeinfo:eu-repo/semantics/reviewes
dc.typeinfo:eu-repo/semantics/reviewes
dc.typeArticlees
dc.identifier.doi10.1113/jphysiol.2003.045112
dc.identifier.scopus0041854177-
dc.identifier.isi000185247700034
dcterms.isPartOfJournal Of Physiology-London
dcterms.sourceJournal Of Physiology-London[ISSN 0022-3751],v. 551 (1), p. 379-386
dc.contributor.authorscopusid7004323423
dc.identifier.crisid475-
dc.identifier.eissn1469-7793-
dc.description.lastpage386
dc.description.firstpage379
dc.relation.volume551
dc.investigacionCiencias de la Saludes
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.type2Reseñaes
dc.identifier.wosWOS:000185247700034-
dc.contributor.daisngid90295
dc.identifier.investigatorRIDH-6693-2015
dc.contributor.wosstandardWOS:Calbet, JAL
dc.date.coverdateAgosto 2003
dc.identifier.ulpgces
item.grantfulltextopen-
item.fulltextCon texto completo-
crisitem.author.deptRendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Educación Física-
crisitem.author.orcid0000-0002-9215-6234-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameLópez Calbet, José Antonio-
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