Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/6540
Campo DC Valoridioma
dc.contributor.authorRobach, Paulen_US
dc.contributor.authorCalbet, José A.L.en_US
dc.contributor.authorThomsen, Jonas J.en_US
dc.contributor.authorBoushel, Roberten_US
dc.contributor.authorMollard, Pascalen_US
dc.contributor.authorRasmussen, Peteren_US
dc.contributor.authorLundby, Carstenen_US
dc.date.accessioned2011-10-27T02:31:00Z-
dc.date.accessioned2018-03-08T13:10:52Z-
dc.date.available2011-10-27T11:53:37Z-
dc.date.available2018-03-08T13:10:52Z-
dc.date.issued2008en_US
dc.identifier.issn1932-6203en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/6540-
dc.description.abstractTreatment with recombinant human erythropoietin (rhEpo) induces a rise in blood oxygen-carrying capacity (CaO(2)) that unequivocally enhances maximal oxygen uptake (VO(2)max) during exercise in normoxia, but not when exercise is carried out in severe acute hypoxia. This implies that there should be a threshold altitude at which VO(2)max is less dependent on CaO(2). To ascertain which are the mechanisms explaining the interactions between hypoxia, CaO(2) and VO(2)max we measured systemic and leg O(2) transport and utilization during incremental exercise to exhaustion in normoxia and with different degrees of acute hypoxia in eight rhEpo-treated subjects. Following prolonged rhEpo treatment, the gain in systemic VO(2)max observed in normoxia (6-7%) persisted during mild hypoxia (8% at inspired O(2) fraction (F(I)O(2)) of 0.173) and was even larger during moderate hypoxia (14-17% at F(I)O(2) = 0.153-0.134). When hypoxia was further augmented to F(I)O(2) = 0.115, there was no rhEpo-induced enhancement of systemic VO(2)max or peak leg VO(2). The mechanism highlighted by our data is that besides its strong influence on CaO(2), rhEpo was found to enhance leg VO(2)max in normoxia through a preferential redistribution of cardiac output toward the exercising legs, whereas this advantageous effect disappeared during severe hypoxia, leaving augmented CaO(2) alone insufficient for improving peak leg O(2) delivery and VO(2). Finally, that VO(2)max was largely dependent on CaO(2) during moderate hypoxia but became abruptly CaO(2)-independent by slightly increasing the severity of hypoxia could be an indirect evidence of the appearance of central fatigue.en_US
dc.languageengen_US
dc.relation.ispartofPLoS ONEen_US
dc.sourcePLoS ONE [EISSN 1932-6203], v. 3 (8), e2996, (Agosto 2008)en_US
dc.subject241106 Fisiología del ejercicioen_US
dc.subject.otherExercise-
dc.subject.otherErythropoietin-
dc.subject.otherOxygen-
dc.subject.otherArterial Hypoxemia-
dc.titleThe ergogenic effect of recombinant human erythropoietin on VO2max depends on the severity of arterial hypoxemiaen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0002996en_US
dc.identifier.scopus51849131589-
dc.contributor.authorscopusid6603355287-
dc.contributor.authorscopusid7004323423-
dc.contributor.authorscopusid14631433200-
dc.contributor.authorscopusid7003471688-
dc.contributor.authorscopusid56212540500-
dc.contributor.authorscopusid57203104826-
dc.contributor.authorscopusid57203056925-
dc.identifier.crisid-;475;-;-;-;-;--
dc.identifier.eissn1932-6203-
dc.identifier.issue8-
dc.relation.volume3en_US
dc.investigacionCiencias de la Salud-
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess-
dc.type2Artículoen_US
dc.identifier.external-;475;-;-;-;-;--
dc.utils.revision-
dc.date.coverdateAgosto 2008en_US
dc.identifier.supplement-;475;-;-;-;-;--
dc.identifier.ulpgc-
dc.description.scieSCIE
dc.description.erihplusERIH PLUS
item.fulltextCon texto completo-
item.grantfulltextopen-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Educación Física-
crisitem.author.orcid0000-0002-9215-6234-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameLópez Calbet, José Antonio-
Colección:Artículos
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