Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/63296
Título: Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Autores/as: Fernandez-Cao, Jose C.
Warthon-Medina, Marisol
Moran, Victoria H.
Arija, Victoria
Doepking, Carlos
Serra Majem, Luis 
Lowe, Nicola M.
Clasificación UNESCO: 32 Ciencias médicas
Palabras clave: Serum Trace-Elements
Metabolic Syndrome
Postmenopausal Women
Regional Burden
Meta-Regression, et al.
Fecha de publicación: 2019
Publicación seriada: Nutrients 
Resumen: Zinc could have a protective role against type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis aimed to evaluate the association between dietary, supplementary, and total zinc intake, as well as serum/plasma and whole blood zinc concentration, and risk of T2DM. Observational studies, conducted on cases of incident diabetes or T2DM patients and healthy subjects that reported a measure of association between zinc exposure and T2DM, were selected. Random effects meta-analyses were applied to obtain combined results. Stratified meta-analyses and meta-regressions were executed to assess sources of heterogeneity, as well as the impact of covariates on the findings. From 12,136 publications, 16 studies were selected. The odds ratio (OR) for T2DM comparing the highest versus lowest zinc intake from diet was 0.87 (95% CI: 0.78-0.98). Nevertheless, no association between supplementary or total zinc intake from both diet and supplementation, and T2DM was observed. A direct relationship was found between serum/plasma zinc levels and T2DM (OR = 1.64, 95% CI: 1.25-2.14). A moderately high dietary zinc intake, in relation to the Dietary Reference Intake, could reduce by 13% the risk of T2DM, and up to 41% in rural areas. Conversely, elevated serum/plasma zinc concentration was associated with an increased risk of T2DM by 64%, suggesting disturbances in zinc homeostasis.
URI: http://hdl.handle.net/10553/63296
ISSN: 2072-6643
DOI: 10.3390/nu11051027
Fuente: Nutrients [ISSN 2072-6643], v. 11 (5)
Colección:Reseña
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