Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/60168
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dc.contributor.authorToledo Marante, Francisco Javieren_US
dc.contributor.authorBermejo Barrera, Jaimeen_US
dc.contributor.authorEstévez Rosas, Francisco Jesúsen_US
dc.date.accessioned2020-01-15T10:55:25Z-
dc.date.available2020-01-15T10:55:25Z-
dc.date.issued2015en_US
dc.identifier.issn1130-4723en_US
dc.identifier.otherDialnet-
dc.identifier.urihttp://hdl.handle.net/10553/60168-
dc.description.abstractLichen species typically have a characteristic profile of secondary metabolites. One of the most abundant sources of these compounds is the lichen Lethariella canariensis (Ach.) Krog, which is widely distributed on five islands of the Canarian Archipelago. Dense populations of this species grow frequently on volcanic land. Previous studies have demonstrated that lichen substances have more than one phenolic hydroxyl group attached to one or more benzene rings, thus qualifying as polyphenols. The aim of the present study was to re-characterise the suite of secondary metabolites of L. canariensis with modern analytical techniques and to estimate their antioxidant activity. The compounds were identified based on their IR, MS and 1H-NMR spectra as well as retention factors of their TLC analysis. In addition to the previously described secondary metabolites (atranorin and chloroatranorin) of L. canariensis, further ten were identified in its thalli: atranol, chloroatranol, hematommic acid, chlorohematommic acid, methyl hematommate, methyl chlorohematommate, ethyl hematommate, ethyl chlorohematommate, methyl β-orsellinate, and (+)-usnic acid. These polyphenols have been restudied with intention to find compounds protecting against oxidative stress and free radical-induced damage. Protection against lipid peroxidation was investigated using brain homogenates. The mixture Letharal decreased H2O2/Fe+2 induced lipid peroxidation in a concentration-dependent manner. The L. canariensis polyphenols exhibited 180-1339 fold less radical scavenging activity than reference substance α-(+)-tocopherol in DPPH• model expressed by IC50 values.en_US
dc.languagespaen_US
dc.relation.ispartofRevista de la Academia Canaria de Cienciasen_US
dc.sourceRevista de la Academia Canaria de Ciencias: = Folia Canariensis Academiae Scientiarum [ISSN 1130-4723], v. 27 (2), p. 45-62en_US
dc.subject24 Ciencias de la vidaen_US
dc.titleProfundización en el estudio de la actividad antioxidante de los polifenoles de Lethariella canariensis (ACH): Krongen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.urlhttp://dialnet.unirioja.es/servlet/articulo?codigo=5910166-
dc.description.lastpage62-
dc.identifier.issue2-
dc.description.firstpage45-
dc.relation.volume27-
dc.investigacionCienciasen_US
dc.type2Artículoen_US
dc.contributor.authordialnetid2320419-
dc.contributor.authordialnetidNo ID-
dc.contributor.authordialnetid4196020-
dc.identifier.dialnet5910166ARTREV-
dc.utils.revisionen_US
dc.identifier.ulpgces
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Bioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0002-7842-591X-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameToledo Marante, Francisco Javier-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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