Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/59988
DC FieldValueLanguage
dc.contributor.authorHernández, Julia N.en_US
dc.contributor.authorMeeusen, Elsen_US
dc.contributor.authorRodríguez, Franciscoen_US
dc.contributor.authorPiedrafita, Daviden_US
dc.contributor.authorGonzález, Jorge F.en_US
dc.date.accessioned2019-12-29T09:55:43Z-
dc.date.available2019-12-29T09:55:43Z-
dc.date.issued2020en_US
dc.identifier.issn0141-9838en_US
dc.identifier.otherScopus-
dc.identifier.urihttp://hdl.handle.net/10553/59988-
dc.description.abstractEosinophils are prominent effector cells in immune responses against gastrointestinal nematode infections in ruminants, but their in vivo role has been hard to establish in large animals. Interleukin-5 is a key cytokine in the induction and stimulation of anti-parasitic eosinophil responses. This study attempted to modulate the eosinophil response in sheep through vaccination with recombinant interleukin-5 (rIL-5) and determine the effect on subsequent Haemonchus contortus infection. Nematode-resistant Canaria Hair Breed (CHB) sheep vaccinated with rIL-5 in Quil-A adjuvant, had lower blood eosinophil counts and higher mean worm burdens than control sheep vaccinated with Quil-A adjuvant alone. In addition, adult worms in IL-5-vaccinated sheep were significantly longer with higher eggs in utero in female worms, supporting an active role of eosinophils against adult parasites in CHB sheep. These results confirm that eosinophils can play a direct role in effective control of H contortus infection in sheep and offer a new approach to study immune responses in ruminants.en_US
dc.languageengen_US
dc.relation.ispartofParasite Immunologyen_US
dc.sourceParasite Immunology [ISSN 0141-9838], v. 42 (e12680)en_US
dc.subjectInvestigaciónen_US
dc.subject.otherCanaria Hair Breed sheepen_US
dc.subject.otherCytokine vaccinationen_US
dc.subject.otherEosinophilsen_US
dc.subject.otherGastrointestinal nematodesen_US
dc.subject.otherHaemonchus contortusen_US
dc.subject.otherHelminth immunityen_US
dc.subject.otherInterleukin‐5en_US
dc.titleIncreased susceptibility to Haemonchus contortus infection by interleukin-5 modulation of eosinophil responses in sheepen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1111/pim.12680
dc.identifier.scopus85076360217
dc.contributor.authorscopusid57188977277
dc.contributor.authorscopusid7004807083
dc.contributor.authorscopusid21641919200
dc.contributor.authorscopusid6602358369
dc.contributor.authorscopusid7404492965
dc.identifier.issuee12680-
dc.relation.volume42-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.ulpgces
dc.description.sjr0,795
dc.description.jcr2,28
dc.description.sjrqQ2
dc.description.jcrqQ3
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.deptGIR IUSA-ONEHEALTH1: Epidemiología, Medicina Preventiva Veterinaria y Zoonosis-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Morfología-
crisitem.author.deptGIR IUSA-ONEHEALTH 4. Producción y Biotecnología Animal-
crisitem.author.deptIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.deptDepartamento de Patología Animal, Producción Animal, Bromatología y Tecnología de Los Alimentos-
crisitem.author.orcid0000-0002-3843-2509-
crisitem.author.orcid0000-0002-4968-5333-
crisitem.author.orcid0000-0001-8692-990X-
crisitem.author.orcid0000-0001-7374-9256-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.parentorgIU de Sanidad Animal y Seguridad Alimentaria-
crisitem.author.fullNameHernández Vega, Julia Natividad-
crisitem.author.fullNameRodríguez Guisado, Francisco-
crisitem.author.fullNamePiedrafita, David-
crisitem.author.fullNameGonzález Pérez, Jorge Francisco-
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