Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/56211
DC FieldValueLanguage
dc.contributor.authorSantana Viera, Sergio-
dc.contributor.authorMarzullo, Luca-
dc.contributor.authorTorres Padrón, María Esther-
dc.contributor.authorDel Bubba, Massimo-
dc.contributor.authorSosa Ferrera, María Zoraida-
dc.contributor.authorSantana Rodríguez, José Juan-
dc.date.accessioned2019-07-24T12:26:01Z-
dc.date.available2019-07-24T12:26:01Z-
dc.date.issued2019-
dc.identifier.issn0889-1575-
dc.identifier.otherWoS-
dc.identifier.urihttp://hdl.handle.net/10553/56211-
dc.description.abstractPresence of antineoplastic compounds in the marine environment could cause adverse effects even at very low concentrations. The bulk of the produced literature at present has focused on the detection of these compounds in wastewater samples, while only a few papers tackled the more complex solid samples and until now, to the best of our knowledge, none has investigated marine organisms. This work presents the development, optimisation and application of an analytical method for the extraction and determination of the four antineoplastic compounds; cyclophosphamide, vincristine, vinblastine and tamoxifen, from fish tissues by microwave assisted extraction and ultra-high-performance liquid chromatography coupled to tandem mass spectrometry. Under optimal conditions, recoveries ranged between 60% and 120%, while intra- and inter-day precision were in the 5.0–19.4% and 12.0–20.4% ranges, respectively. Method detection and quantification limits were in the ranges 0.8–1.3 and 2.7-4.3 ng·g−1 dry weight for tamoxifen and cyclophosphamide, and 46.3–536 and 154-1787 ng·g−1 dry weight for vinblastine and vincristine, respectively. The developed analytical method was successfully applied for the extraction and determination of target compounds from muscle and liver tissues belonging to three different fish species. The results did not highlight any contamination by target antineoplastic molecules in the investigated fish tissues.-
dc.languageeng-
dc.relation.ispartofJournal of Food Composition and Analysis-
dc.sourceJournal of Food Composition and Analysis [ISSN 0889-1575], v. 82, 103241-
dc.subject2301 química analítica-
dc.subject330811 Control de la contaminación del agua-
dc.subject.otherAntineoplastic compounds-
dc.subject.otherFish tissue-
dc.subject.otherSolid samples-
dc.subject.otherMicrowave assisted extraction-
dc.subject.otherLiquid chromatography-
dc.subject.otherMass spectrometry-
dc.titleMicrowave assisted extraction for the determination of antineoplastic compounds in marine fish-
dc.typeinfo:eu-repo/semantics/article-
dc.typeArticle-
dc.identifier.doi10.1016/j.jfca.2019.103241-
dc.identifier.scopus85068723293-
dc.identifier.isi000482528800022-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.orcid#NODATA#-
dc.contributor.authorscopusid56971376800-
dc.contributor.authorscopusid57209778850-
dc.contributor.authorscopusid8452532700-
dc.contributor.authorscopusid6602749777-
dc.contributor.authorscopusid6602897915-
dc.contributor.authorscopusid56248783900-
dc.identifier.eissn1096-0481-
dc.description.firstpage103241-
dc.relation.volume82-
dc.investigacionCiencias-
dc.type2Artículo-
dc.contributor.daisngid7527074-
dc.contributor.daisngid31729565-
dc.contributor.daisngid22437017-
dc.contributor.daisngid471322-
dc.contributor.daisngid770178-
dc.contributor.daisngid10914640-
dc.description.numberofpages8-
dc.contributor.wosstandardWOS:Santana-Viera, S-
dc.contributor.wosstandardWOS:Marzullo, L-
dc.contributor.wosstandardWOS:Padron, MET-
dc.contributor.wosstandardWOS:Del Bubba, M-
dc.contributor.wosstandardWOS:Sosa-Ferrera, Z-
dc.contributor.wosstandardWOS:Santana-Rodriguez, JJ-
dc.date.coverdateSeptiembre 2019-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptDepartamento de Química-
crisitem.author.deptAnálisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptDepartamento de Química-
crisitem.author.deptAnálisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.deptDepartamento de Química-
crisitem.author.deptAnálisis Químico Medioambiental-
crisitem.author.deptIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.orcid0000-0002-2412-0037-
crisitem.author.orcid0000-0001-7000-4419-
crisitem.author.orcid0000-0003-3003-3607-
crisitem.author.orcid0000-0002-5635-7215-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.parentorgIU de Estudios Ambientales y Recursos Naturales-
crisitem.author.fullNameSantana Viera, Sergio-
crisitem.author.fullNameTorres Padrón, María Esther-
crisitem.author.fullNameSosa Ferrera, María Zoraida-
crisitem.author.fullNameSantana Rodríguez, José Juan-
crisitem.author.departamentoQuímica-
crisitem.author.departamentoQuímica-
crisitem.author.departamentoQuímica-
Appears in Collections:Artículos
Show simple item record

SCOPUSTM   
Citations

1
checked on Apr 11, 2020

WEB OF SCIENCETM
Citations

1
checked on May 23, 2020

Page view(s)

11
checked on May 23, 2020

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.