Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/55064
DC FieldValueLanguage
dc.contributor.authorMolero, Patricioen_US
dc.contributor.authorRuiz-Estigarribia, Lizen_US
dc.contributor.authorLahortiga-Ramos, Franciscaen_US
dc.contributor.authorSánchez-Villegas, Almudenaen_US
dc.contributor.authorBes-Rastrollo, Mairaen_US
dc.contributor.authorEscobar-González, Marcosen_US
dc.contributor.authorMartínez-González, Miguel Ángelen_US
dc.contributor.authorFernández-Montero, Alejandroen_US
dc.date.accessioned2019-02-18T16:21:55Z-
dc.date.available2019-02-18T16:21:55Z-
dc.date.issued2019en_US
dc.identifier.issn0165-0327en_US
dc.identifier.urihttp://hdl.handle.net/10553/55064-
dc.description.abstractBackground: The potential effect of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) to prevent depression remains largely unknown, in spite of the implication of inflammation in depression. This study aimed to investigate whether the habitual intake of aspirin and other NSAIDs was prospectively associated with a reduction in the observed incidence of depression.Methods: A dynamic cohort including 22,564 Spanish university graduates (mean age: 37 years) initially free of depression was followed during an average of 8.7 years. Exposure to NSAIDs was assessed with specific repeated questionnaires throughout follow-up, starting in the 2-year follow-up questionnaire. Incident cases of depression were defined as either a new validated medical diagnosis of depression or reporting the initiation of habitual use of antidepressants.Results: We identified 772 incident cases of depression. Regular intake of aspirin and other NSAIDs was not associated with depression risk. Only in secondary sensitivity analyses using a definition of the outcome with higher specificity (a validated medical diagnosis of depression), an inverse association of aspirin with depression was found [HR (95%CI): 0.20 (0.04-0.87)]. However, these results were non-significant after adjustment for multiple testing.Limitations: A possible underestimation of incident depression and a limited ability to detect all possible residual confounding.Conclusions: Regular use of NSAIDs was not associated with the incidence of depression. Further longitudinal controlled studies are necessary to clarify a potential role of aspirin use in depression risk.
dc.languagespaen_US
dc.publisher0165-0327
dc.relation.ispartofJournal of Affective Disordersen_US
dc.sourceJournal of Affective Disorders[ISSN 0165-0327],v. 247, p. 161-167en_US
dc.subject.otherPhysical-Activity
dc.subject.otherSymptoms
dc.subject.otherQuestionnaire
dc.subject.otherInflammation
dc.subject.otherValidation
dc.subject.otherHealth
dc.subject.otherWomen
dc.titleUse of non-steroidal anti-inflammatory drugs, aspirin and the risk of depression: The “Seguimiento Universidad de Navarra (SUN)” cohorten_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jad.2019.01.020
dc.identifier.scopus85060136418
dc.identifier.isi000457143600019
dc.contributor.authorscopusid23973669400
dc.contributor.authorscopusid57203962637
dc.contributor.authorscopusid8573786900
dc.contributor.authorscopusid6602876903
dc.contributor.authorscopusid56247740200
dc.contributor.authorscopusid57205469682
dc.contributor.authorscopusid7004290629
dc.contributor.authorscopusid46761091200
dc.description.lastpage167-
dc.description.firstpage161-
dc.relation.volume247-
dc.type2Artículoen_US
dc.contributor.daisngid1445373
dc.contributor.daisngid29188923
dc.contributor.daisngid6499560
dc.contributor.daisngid289030
dc.contributor.daisngid154711
dc.contributor.daisngid29613655
dc.contributor.daisngid17754
dc.contributor.daisngid8401242
dc.contributor.wosstandardWOS:Molero, P
dc.contributor.wosstandardWOS:Ruiz-Estigarribia, L
dc.contributor.wosstandardWOS:Lahortiga-Ramos, F
dc.contributor.wosstandardWOS:Sanchez-Villegas, A
dc.contributor.wosstandardWOS:Bes-Rastrollo, M
dc.contributor.wosstandardWOS:Escobar-Gonzalez, M
dc.contributor.wosstandardWOS:Martinez-Gonzalez, MA
dc.contributor.wosstandardWOS:Fernandez-Montero, A
dc.date.coverdateMarzo 2019
dc.identifier.ulpgces
dc.description.sjr1,945
dc.description.jcr3892,0
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
dc.description.ssciSSCI
dc.description.erihplusERIH PLUS
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Nutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0001-7733-9238-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSánchez Villegas,Almudena-
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