Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/55012
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dc.contributor.authorSaavedra Díaz, Ester Gloriaen_US
dc.contributor.authorDel Rosario, Henocen_US
dc.contributor.authorBrouard, Ignacioen_US
dc.contributor.authorQuintana, Joséen_US
dc.contributor.authorEstévez, Franciscoen_US
dc.date.accessioned2019-02-18T16:08:11Z-
dc.date.available2019-02-18T16:08:11Z-
dc.date.issued2019en_US
dc.identifier.issn0009-2797en_US
dc.identifier.urihttp://hdl.handle.net/10553/55012-
dc.description.abstractIn this study, we investigated the effects of synthetic 6'-benzyloxy-4-bromo-2'-hydroxychalcone on viabilities of seven human leukaemia cells. It was cytotoxic against U-937, HL-60, K-562, NALM-6, MOLT-3 cells, and also against Bcl-2-overexpressing U-937/Bcl-2 cells and P-glycoprotein-overexpressing K-562/ADR, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. This chalcone is a potent apoptotic inducer in human leukaemia U-937 cells. Cell death was (i) mediated by the activation and the cleavage of initiator and executioner caspases and poly(ADP-ribose) polymerase; (ii) prevented by the pan-caspase inhibitor z-VAD-fmk, and by the selective caspase-3/7, -6 and -8 inhibitors, and by a cathepsins B/L inhibitor; (iii) associated with the release of mitochondrial proteins, including cytochrome c and Smac/DIABLO; (iv) accompanied by dissipation of the mitochondrial membrane potential, (v) partially blocked by the inhibition of p38(MAPK) and (vi) mostly abrogated by catalase. In conclusion, the synthetic chalcone is cytotoxic against several types of human leukaemia cell with apoptosis being induced by activation of the extrinsic pathway and the generation of reactive oxygen species.en_US
dc.languagespaen_US
dc.publisher0009-2797
dc.relation.ispartofChemico-biological interactions (Print)en_US
dc.sourceChemico-Biological Interactions[ISSN 0009-2797],v. 298, p. 137-145en_US
dc.subject.otherActivated Protein-Kinaseen_US
dc.subject.otherMitochondrial Dysfunctionen_US
dc.subject.otherCanceren_US
dc.subject.otherChalconesen_US
dc.subject.otherInductionen_US
dc.subject.otherProliferationen_US
dc.subject.otherProgressionen_US
dc.subject.otherInhibitionen_US
dc.subject.otherFlavonolsen_US
dc.subject.otherSurvivalen_US
dc.title6′-Benzyloxy-4-bromo-2′-hydroxychalcone is cytotoxic against human leukaemia cells and induces caspase-8- and reactive oxygen species-dependent apoptosisen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.cbi.2018.12.010en_US
dc.identifier.scopus85058778065-
dc.identifier.isi000454538500018-
dc.contributor.authorscopusid57190224633-
dc.contributor.authorscopusid57190227049-
dc.contributor.authorscopusid6603470039-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7003810011-
dc.description.lastpage145en_US
dc.description.firstpage137en_US
dc.relation.volume298en_US
dc.type2Artículoen_US
dc.contributor.daisngid10748553-
dc.contributor.daisngid13640797-
dc.contributor.daisngid657275-
dc.contributor.daisngid128315-
dc.contributor.daisngid384944-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Saavedra, E-
dc.contributor.wosstandardWOS:Del Rosario, H-
dc.contributor.wosstandardWOS:Brouard, I-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.date.coverdateEnero 2019en_US
dc.identifier.ulpgcen_US
dc.description.sjr0,896
dc.description.jcr3,723
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Bioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.deptGIR IUIBS: Bioquímica Farmacológica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología.-
crisitem.author.orcid0000-0002-1717-386X-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameSaavedra Díaz, Ester Gloria-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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