Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/54987
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dc.contributor.authorOosterloo, Maykeen_US
dc.contributor.authorBijlsma, Emilia K.en_US
dc.contributor.authorvan Kuijk, Sander MJen_US
dc.contributor.authorMinkels, Flooren_US
dc.contributor.authorde Die-Smulders, Christine EMen_US
dc.contributor.authorBachoud-Lévi, Anne Catherineen_US
dc.contributor.authorBentivoglio, Anna Ritaen_US
dc.contributor.authorBiunno, Idaen_US
dc.contributor.authorBonelli, Raphael M.en_US
dc.contributor.authorBronzova, Julianaen_US
dc.contributor.authorBurgunder, Jean Marcen_US
dc.contributor.authorDunnett, Stephen B.en_US
dc.contributor.authorFerreira, Joaquim J.en_US
dc.contributor.authorFrich, Janen_US
dc.contributor.authorGiuliano, Joeen_US
dc.contributor.authorHandley, Olivia J.en_US
dc.contributor.authorHeiberg, Arviden_US
dc.contributor.authorIllarioshkin, Sergeyen_US
dc.contributor.authorIllmann, Torstenen_US
dc.contributor.authorKlempir, Jirien_US
dc.contributor.authorLandwehrmeyer, G. Bernharden_US
dc.contributor.authorLevey, Jamieen_US
dc.contributor.authorMcLean, Timen_US
dc.contributor.authorNielsen, Jørgen E.en_US
dc.contributor.authorKoivisto, Susana Proen_US
dc.contributor.authorPäivärinta, Markkuen_US
dc.contributor.authorPålhagen, Svenen_US
dc.contributor.authorQuarrell, Oliveren_US
dc.contributor.authorRamos-Arroyo, Mariaen_US
dc.contributor.authorRoos, Raymund A.C.en_US
dc.contributor.authorSaft, Carstenen_US
dc.contributor.authorSebastián, Ana Rojoen_US
dc.contributor.authorTabrizi, Sarah J.en_US
dc.contributor.authorVandenberghe, Wimen_US
dc.contributor.authorVerellen-Dumoulin, Christineen_US
dc.contributor.authorUhrova, Terezaen_US
dc.contributor.authorWahlström+, Janen_US
dc.contributor.authorZaremba, Jaceken_US
dc.contributor.author(formerly Rödig, Verena Baakeen_US
dc.contributor.authorBarth, Katrinen_US
dc.contributor.authorGarde, Monica Bascuñanaen_US
dc.contributor.authorBecanovic, Kristinaen_US
dc.contributor.authorBernard, Tomášen_US
dc.contributor.authorBetz, Sabrinaen_US
dc.contributor.authorBos, Reinekeen_US
dc.contributor.authorCome, Adrienen_US
dc.contributor.authorGuedes, Leonor Correiaen_US
dc.contributor.authorCallaghan, Jennyen_US
dc.contributor.authorCapodarca, Seleneen_US
dc.contributor.authorCharpentier, Sébastienen_US
dc.contributor.authorVieira da Silva, Wildsonen_US
dc.contributor.authorDi Renzo, Martinaen_US
dc.contributor.authorEcker, Danielen_US
dc.contributor.authorFinisterra, Ana Mariaen_US
dc.contributor.authorFullam, Ruthen_US
dc.contributor.authorGenoves, Camilleen_US
dc.contributor.authorGilling, Metteen_US
dc.contributor.authorHorta, Andreaen_US
dc.contributor.authorHvalstedt, Carinaen_US
dc.contributor.authorHeld, Christineen_US
dc.contributor.authorHussain, Hasinaen_US
dc.contributor.authorKoppers, Kerstinen_US
dc.contributor.authorLamanna, Claudiaen_US
dc.contributor.authorLaurà, Matildeen_US
dc.contributor.authorDescals, Asunción Martínezen_US
dc.contributor.authorMartinez-Horta, Saulen_US
dc.contributor.authorMestre, Tiagoen_US
dc.contributor.authorMinster, Saraen_US
dc.contributor.authorMonza, Danielaen_US
dc.contributor.authorMünkel, Kristinaen_US
dc.contributor.authorMütze, Lisanneen_US
dc.contributor.authorOehmen, Martinen_US
dc.contributor.authorPadieu, Heleneen_US
dc.contributor.authorPaterski, Laurenten_US
dc.contributor.authorPeppa, Nadiaen_US
dc.contributor.authorRindal, Beateen_US
dc.contributor.authorRogers, Dawnen_US
dc.contributor.authorRøren (formerly Heinonen), Niinien_US
dc.contributor.authorSalgueiro, Anaen_US
dc.contributor.authorŠašinková, Pavlaen_US
dc.contributor.authorSeliverstov, Yuryen_US
dc.contributor.authorTaylor, Catherineen_US
dc.contributor.authorTimewell, Erikaen_US
dc.contributor.authorTownhill, Jennyen_US
dc.contributor.authorCubillo, Patricia Trigoen_US
dc.contributor.authorvan Walsem, Marleen R.en_US
dc.contributor.authorWitjes-Ané, Marie Noelleen_US
dc.contributor.authorWitkowski, Grzegorzen_US
dc.contributor.authorWright, Abigailen_US
dc.contributor.authorYudina, Elizavetaen_US
dc.contributor.authorZielonka, Danielen_US
dc.contributor.authorZielonka, Eugeniuszen_US
dc.contributor.authorZinzi, Paolaen_US
dc.contributor.authorHecht, Karenen_US
dc.contributor.authorHerranhof, Brigitteen_US
dc.date.accessioned2019-02-18T16:01:23Z-
dc.date.available2019-02-18T16:01:23Z-
dc.date.issued2019en_US
dc.identifier.issn1353-8020en_US
dc.identifier.urihttp://hdl.handle.net/10553/54987-
dc.description.abstractBackground: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30-50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P < .001). Overall motor and cognitive performance (P < .001) were worse, however only disease motor progression was slower (coefficient, -0.58; SE 0.16; P < .001) compared to the common-onset group. Repeat size was significantly lower in the late-onset (n = 40.8; SD 1.6) compared to common-onset (n = 44.4; SD 2.8) (P < .001). Fewer late-onset patients (n = 451) had a positive family history compared to common-onset (n = 2940) (P < .001). Conclusions: Late-onset patients present more frequently with gait and balance problems as first symptom, and disease progression is not milder compared to common-onset HD patients apart from motor progression. The family history is likely to be negative, which might make diagnosing HD more difficult in this population. However, the balance and gait problems might be helpful in diagnosingen_US
dc.languageengen_US
dc.publisher1353-8020
dc.relation.ispartofParkinsonism and Related Disordersen_US
dc.sourceParkinsonism and Related Disorders[ISSN 1353-8020], n. 61, p. 101-105en_US
dc.subject32 Ciencias médicasen_US
dc.subject.otherAge of onseten_US
dc.subject.otherHuntington's diseaseen_US
dc.subject.otherLate-onset Huntington's diseaseen_US
dc.titleClinical and genetic characteristics of late-onset Huntington's diseaseen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.parkreldis.2018.11.009en_US
dc.identifier.scopus85057810348-
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dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,478
dc.description.jcr3,926
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
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