Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/54896
DC FieldValueLanguage
dc.contributor.authorJiang, Ningen_US
dc.contributor.authorKe, Binghuen_US
dc.contributor.authorHjort-Jensen, Kimen_US
dc.contributor.authorIglesias-Gato, Diegoen_US
dc.contributor.authorWang, Zhunen_US
dc.contributor.authorChang, Pengchengen_US
dc.contributor.authorZhao, Yangen_US
dc.contributor.authorNiu, Xiaodanen_US
dc.contributor.authorWu, Taoen_US
dc.contributor.authorPeng, Boen_US
dc.contributor.authorJiang, Mingdongen_US
dc.contributor.authorLi, Xiaoshien_US
dc.contributor.authorShang, Zhiqunen_US
dc.contributor.authorWang, Qiangen_US
dc.contributor.authorChang, Chawnshangen_US
dc.contributor.authorFlores Morales, Amilcaren_US
dc.contributor.authorNiu, Yuanjieen_US
dc.date.accessioned2019-02-18T15:30:40Z-
dc.date.available2019-02-18T15:30:40Z-
dc.date.issued2017en_US
dc.identifier.issn1949-2553en_US
dc.identifier.urihttp://hdl.handle.net/10553/54896-
dc.description.abstractCastration resistant prostate cancer (CRPC) is a stage of relapse that arises after various forms of androgen ablation therapy (ADT) and causes significant morbidity and mortality. However, the mechanism underlying progression to CRPC remains poorly understood. Here, we report that YAP1, which is negatively regulated by AR, influences prostate cancer (PCa) cell self-renewal and CRPC development. Specifically, we found that AR directly regulates the methylation of YAP1 gene promoter via the formation of a complex with Polycomb group protein EZH2 and DNMT3a. In normal conditions, AR recruits EZH2 and DNMT3a to YAP1 promoter, thereby promoting DNA methylation and the repression of YAP1 gene transcription. Following ADT treatment or when AR activity is antagonized by Bicalutamide or Enzalutamide, YAP1 gene expression is switched on. In turn, YAP1 promotes SOX2 and Nanog expression and the de-differentiation of PCa cells to stem/progenitor-like cells (PCSC), which potentially contribute to disease recurrence. Finally, the knock down of YAP1 expression or the inhibition of YAP1 function by Verteporfin in TRAMP prostate cancer mice significantly suppresses tumor recurrence following castration. In conclusion, our data reveals that AR suppresses YAP1 gene expression through a novel epigenetic mechanism, which is critical for PCa cells self-renewal and the development of CRPC.en_US
dc.languageengen_US
dc.relation.ispartofOncotargeten_US
dc.sourceOncotarget [ISSN 1949-2553], v. 8, p. 115054-115067en_US
dc.titleYAP1 regulates prostate cancer stem cell-like characteristics to promote castration resistant growthen_US
dc.typeinfo:eu-repo/semantics/articleen_US
dc.typeArticleen_US
dc.identifier.doi10.18632/oncotarget.23014en_US
dc.identifier.scopus85039742594-
dc.contributor.authorscopusid35744765600-
dc.contributor.authorscopusid57200113578-
dc.contributor.authorscopusid57200110345-
dc.contributor.authorscopusid36664682600-
dc.contributor.authorscopusid55798068900-
dc.contributor.authorscopusid57200113005-
dc.contributor.authorscopusid57202271564-
dc.contributor.authorscopusid56493963300-
dc.contributor.authorscopusid57199835857-
dc.contributor.authorscopusid7102873085-
dc.contributor.authorscopusid57200999365-
dc.contributor.authorscopusid55906205300-
dc.contributor.authorscopusid55533306000-
dc.contributor.authorscopusid57192981151-
dc.contributor.authorscopusid7407036371-
dc.contributor.authorscopusid57203543358-
dc.contributor.authorscopusid24734125700-
dc.description.lastpage115067en_US
dc.description.firstpage115054en_US
dc.relation.volume8en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.utils.revisionen_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,942
dc.description.sjrqQ1
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-0828-8921-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameFlores Morales,Amilcar-
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