Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/54885
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dc.contributor.authorTravés, Paqui G.
dc.contributor.authorPimentel-Santillana, María
dc.contributor.authorRico, Daniel
dc.contributor.authorRodriguez, Nuria
dc.contributor.authorMiethke, Thomas
dc.contributor.authorCastrillo, Antonio
dc.contributor.authorTheodorakis, Emmanuel A.
dc.contributor.authorMartín-Sanz, Paloma
dc.contributor.authorPalladino, Michael A.
dc.contributor.authorBoscá, Lisardo
dc.date.accessioned2019-02-18T15:24:29Z-
dc.date.available2019-02-18T15:24:29Z-
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/10553/54885-
dc.description.abstractCopyright © 2014 Elsevier Ltd. All rights reserved.The effect of acanthoic acid analogs on the response to proinflammatory challenge was investigated. Some pimarane diterpenes are known activators of the LXRαβ nuclear receptors, but we show here that they also exert a rapid, potent, and selective activation of the p110γ and p110δ subunits of PI3K. Combination of these effects results in an important attenuation of the global transcriptional response to LPS in macrophages. PI3K/Akt activation leads to inhibition of the LPS-dependent stimulation of IKK/NF-κB and p38 and ERK MAPKs. Macrophages from LXRαβ-deficient mice exhibited an inhibition of these pathways similar to the corresponding wild-type cells. Silencing or inhibition of p110γ/δ suppressed the effect of these diterpenes (DTPs) on IKK/NF-κB and MAPKs signaling. Taken together, these data show a multitarget anti-inflammatory mechanism by these DTPs including a selective activation of PI3K isoenzymes.
dc.relation.ispartofChemistry & biology
dc.sourceChemistry & biology,v. 21, p. 955-966
dc.titleAnti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110γ/δ subunits and inhibition of NF-κB
dc.typeinfo:eu-repo/semantics/Article
dc.typeArticle
dc.identifier.doi10.1016/j.chembiol.2014.06.005
dc.identifier.scopus85027950571
dc.contributor.authorscopusid9236587900
dc.contributor.authorscopusid54950124000
dc.contributor.authorscopusid57205336150
dc.contributor.authorscopusid35923907400
dc.contributor.authorscopusid7003291193
dc.contributor.authorscopusid55445301000
dc.contributor.authorscopusid7005972947
dc.contributor.authorscopusid57196054763
dc.contributor.authorscopusid35461882200
dc.contributor.authorscopusid35514045400
dc.description.lastpage966
dc.description.firstpage955
dc.relation.volume21
dc.type2Artículo
dc.date.coverdateAgosto 2014
dc.identifier.ulpgces
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-2057-2159-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameCastrillo Viguera, Antonio Jesús-
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