Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/54539
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dc.contributor.authorShariati, F.
dc.contributor.authorPérez-Arellano, J. L.
dc.contributor.authorLópez-Abán, J.
dc.contributor.authorEl Behairy, A. M.
dc.contributor.authorMuro, A.
dc.date.accessioned2019-02-18T11:28:33Z-
dc.date.available2019-02-18T11:28:33Z-
dc.date.issued2010
dc.identifier.issn0141-9838
dc.identifier.urihttp://hdl.handle.net/10553/54539-
dc.description.abstractP>This study aims to investigate the role of angiogenic factors in the pathogenesis of experimental strongyloidiasis. Two complementary approaches were used: Firstly, CD1 mice were treated with endostatin, an angiogenesis inhibitor, and infected with Strongyloides venezuelensis. Also, the mechanisms involved in this process were studied. Parasitological examination revealed a significant decrease in egg per gram of faeces, number of collected larvae from lung tissue and number of collected adult females in mice treated with endostatin. Direct mechanisms with diminution of angiogenesis factors and an indirect mechanism with increase of eosinophil perhaps produced their effect. Secondly, the effect of the antigens responsible for stimulation of angiogenic factors [vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2)] from alveolar macrophages and the mechanisms involved in their production were investigated. Alveolar macrophage cells obtained by bronchoalveolar lavage were incubated at different concentrations of somatic and excretory/secretory antigens of S. venezuelensis. Also, mRNA levels of VEGF and FGF2 in macrophage cells were detected by RT-PCR. L3-PBS larvae antigens induced angiogenic factors. The relationship between angiogenesis factors and nitric oxide has been observed using nitric oxide synthase inhibitors.
dc.publisher0141-9838
dc.relation.ispartofParasite Immunology
dc.sourceParasite Immunology[ISSN 0141-9838],v. 32, p. 430-439
dc.subject.otherEndothelial-Growth-Factor
dc.subject.otherNitric-Oxide
dc.subject.otherStercoralis
dc.subject.otherExpression
dc.subject.otherLarvae
dc.subject.otherInflammation
dc.subject.otherEndostatin
dc.subject.otherDiagnosis
dc.subject.otherAntigens
dc.subject.otherProtein
dc.titleRole of angiogenic factors in acute experimental Strongyloides venezuelensis infection
dc.typeinfo:eu-repo/semantics/Article
dc.typeArticle
dc.identifier.doi10.1111/j.1365-3024.2010.01202.x
dc.identifier.scopus77952253051
dc.identifier.isi000277527500006
dc.contributor.authorscopusid35213836900
dc.contributor.authorscopusid7005553929
dc.contributor.authorscopusid12772685900
dc.contributor.authorscopusid42461211000
dc.contributor.authorscopusid7006690116
dc.description.lastpage439
dc.description.firstpage430
dc.relation.volume32
dc.type2Artículo
dc.contributor.daisngid34952138
dc.contributor.daisngid445671
dc.contributor.daisngid1037139
dc.contributor.daisngid4032876
dc.contributor.daisngid409562
dc.contributor.wosstandardWOS:Shariati, F
dc.contributor.wosstandardWOS:Perez-Arellano, JL
dc.contributor.wosstandardWOS:Lopez-Aban, J
dc.contributor.wosstandardWOS:El Behairy, AM
dc.contributor.wosstandardWOS:Muro, A
dc.date.coverdateJunio 2010
dc.identifier.ulpgces
dc.description.jcr2,357
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Trypanosomosis, Resistencia a Antibióticos y Medicina Animal-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-2936-8242-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNamePérez Arellano, José Luis-
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