Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/54473
Campo DC Valoridioma
dc.contributor.authorMorales, Jesús R.
dc.contributor.authorBallesteros, Iván
dc.contributor.authorDeniz, José Manuel
dc.contributor.authorHurtado, Olivia
dc.contributor.authorVivancos, José
dc.contributor.authorNombela, Florentino
dc.contributor.authorLizasoain, Ignacio
dc.contributor.authorCastrillo, Antonio
dc.contributor.authorMoro, María A.
dc.date.accessioned2019-02-18T11:03:17Z-
dc.date.available2019-02-18T11:03:17Z-
dc.date.issued2008
dc.identifier.issn0009-7322
dc.identifier.urihttp://hdl.handle.net/10553/54473-
dc.description.abstractBackground - The liver X receptors (LXRs) belong to the nuclear receptor superfamily and act as transcriptional regulators of cholesterol metabolism in several tissues. Recent work also has identified LXRs as potent antiinflammatory molecules in macrophages and other immune cells. Combined changes in lipid and inflammatory profiles are likely mediating the protective role of LXRs in models of chronic injury like atherosclerosis. These beneficial actions, however, have not been illustrated in other models of acute injury such as stroke in which inflammation is an important pathophysiological feature. Methods and Results - We have studied LXR expression and function in the course of experimental stroke caused by permanent middle cerebral artery occlusion in rats and mice. Here, we show that administration of the synthetic LXR agonists GW3965 or TO901317 after the ischemic occlusion improves stroke outcome as shown by decreased infarct volume area and better neurological scores in rats. Neuroprotection observed with LXR agonists correlated with decreased expression of proinflammatory genes in the brain and with reduced nuclear factor-κB transcriptional activity. Loss of function studies using LXRα,β mice demonstrated that the effect of LXR agonists is receptor specific. Interestingly, infarcted brain area and inflammatory signaling were significantly extended in LXRα,β mice compared with control animals, indicating that endogenous LXR signaling mediates neuroprotection in this setting. CONCLUSION-: This work highlights the transcriptional action of LXR as a protective pathway in brain injury and the potential use of LXR agonists as therapeutic agents in stroke. © 2008 American Heart Association. All rights reserved.
dc.publisher0009-7322
dc.relation.ispartofCirculation (New York, N.Y.)
dc.sourceCirculation[ISSN 0009-7322],v. 118, p. 1450-1459
dc.titleActivation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke
dc.typeinfo:eu-repo/semantics/Article
dc.typeArticle
dc.identifier.doi10.1161/CIRCULATIONAHA.108.782300
dc.identifier.scopus54049115560
dc.contributor.authorscopusid25422641400
dc.contributor.authorscopusid25421248000
dc.contributor.authorscopusid25421518600
dc.contributor.authorscopusid6603623356
dc.contributor.authorscopusid38562705200
dc.contributor.authorscopusid56048964200
dc.contributor.authorscopusid8729273900
dc.contributor.authorscopusid6504454208
dc.contributor.authorscopusid55445301000
dc.contributor.authorscopusid35508090300
dc.description.lastpage1459
dc.description.firstpage1450
dc.relation.volume118
dc.type2Artículo
dc.date.coverdateSeptiembre 2008
dc.identifier.ulpgces
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Farmacología Molecular y Traslacional-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.orcid0000-0002-2057-2159-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameCastrillo Viguera,Antonio Jesús-
Colección:Artículos
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