Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/54307
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dc.contributor.authorLópez Abán, J.
dc.contributor.authorRamajo, V.
dc.contributor.authorPérez Arellano, J. L.
dc.contributor.authorOleaga, A.
dc.contributor.authorHillyer, G. V.
dc.contributor.authorMuro, A.
dc.date.accessioned2019-02-18T09:58:45Z-
dc.date.available2019-02-18T09:58:45Z-
dc.date.issued1999
dc.identifier.issn0304-4017
dc.identifier.urihttp://hdl.handle.net/10553/54307-
dc.description.abstractThree strains of mice (NMRI, C57/BL, BALB/c) were each immunized with a 12 kDa purified, native Fasciola hepatica fatty acid binding protein (Fh12) and challenged percutaneously with Schistosoma bovis cercariae. C57/BL mice immunized with Fh12 had significant reductions in S. bovis worm burden recoveries (96 and 87% reductions over controls in two separate experiments). When using NMRI or BALB/c mice, Fh12 alone or in Freund's adjuvant failed to induce significant protection against S. bovis. In C57/BL mice vaccinated against Fh12, antibodies to the IgG2a isotype, but not to the IgG1 isotype, increased by 2 weeks after the second immunization and remained high through 8 weeks of S. bovis infection. Antibodies to S. bovis increased after 4 weeks of infection. Regarding cytokine production by spleen mononuclear cells, C57/BL mice vaccinated with Fh12 in adjuvant, and having the highest protective response against challenge infection with S. bovis, had an increase of IFN gamma production with Concanavalin A but no increase of IL-4 in similarly stimulated cells. These results suggest that the protection obtained in this group of mice is mediated by a Th1 immune response. (C) 1999 Elsevier Science B.V. All rights reserved.
dc.publisher0304-4017
dc.relation.ispartofVeterinary Parasitology
dc.sourceVeterinary Parasitology[ISSN 0304-4017],v. 83, p. 107-121
dc.subject.otherGlutathione-S-Transferase
dc.subject.otherNitric-Oxide
dc.subject.otherVaccination
dc.subject.otherMansoni
dc.subject.otherResistance
dc.subject.otherAntigen
dc.subject.otherCattle
dc.subject.otherExpression
dc.subject.otherHaematobium
dc.subject.otherMacrophages
dc.titleA fatty acid binding protein from Fasciola hepatica induced protection in C57/BL mice from challenge infection with Schistosoma bovis
dc.typeinfo:eu-repo/semantics/Article
dc.typeArticle
dc.identifier.doi10.1016/S0304-4017(99)00053-9
dc.identifier.scopus0344085879
dc.identifier.isi000080907700003
dc.contributor.authorscopusid12772685900
dc.contributor.authorscopusid6602697095
dc.contributor.authorscopusid7005553929
dc.contributor.authorscopusid6701820779
dc.contributor.authorscopusid7005288478
dc.contributor.authorscopusid7006690116
dc.description.lastpage121
dc.description.firstpage107
dc.relation.volume83
dc.type2Artículo
dc.contributor.daisngid1037139
dc.contributor.daisngid3319096
dc.contributor.daisngid445671
dc.contributor.daisngid776209
dc.contributor.daisngid208024
dc.contributor.daisngid409562
dc.contributor.wosstandardWOS:Aban, JL
dc.contributor.wosstandardWOS:Ramajo, V
dc.contributor.wosstandardWOS:Arellano, JLP
dc.contributor.wosstandardWOS:Oleaga, A
dc.contributor.wosstandardWOS:Hillyer, GV
dc.contributor.wosstandardWOS:Muro, A
dc.date.coverdateJunio 1999
dc.identifier.ulpgces
dc.description.jcr1,284
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Trypanosomosis, Resistencia a Antibióticos y Medicina Animal-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-2936-8242-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNamePérez Arellano, José Luis-
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