Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/54226
Título: Elevated non-transferrin bound iron in the lungs of patients with Pneumocystis carinii pneumonia
Autores/as: Mateos, Fernando
González, Conceptión
Dominguez, Casimira
Losa, Juan Emilio
Jimenez, Antonio
Pérez-Arellano, José Luis 
Palabras clave: Lower Respiratory-Tract
Deferoxamine
Growth
Fecha de publicación: 1999
Editor/a: 0163-4453
Publicación seriada: Journal of Infection 
Resumen: Objective: The aim of the present work was to determine the concentrations of iron and iron-binding proteins in the lungs of patients suffering from Pneumocystis carinii (PCP), which is crucial for justifying the treatment with iron-chelating agents in this disease.Patients mid Methods: Bronchoalveolar lavage was performed in 10 HIV patients with PCP and five healthy controls. Total iron and iron-binding proteins (transferrin, ferritin and lactoferrin) were measured in acellular bronchoalveolar lavage fluid (BALF) in both groups. Iron was determined by atomic absorption spectrometry; transferrin and lactoferrin were measured using specific enzyme-linked immunosorbent assays (ELISA); and ferritin concentration was quantified by automated immunonephelometry,Results: Our findings in patients with PCP demonstrated a six- to seven-fold increase of total iron levels and an eight-fold increase of ferritin in bronchoalveolar lavage fluid when compared with controls. No significant differences were found in transferrin or lactoferrin levels, Moreover, our results suggest that this iron is non-transferrin bound,Conclusion: Non-transferrin bound iron is increased in the lower respiratory tracts of PCP patients. This finding would lend experiment support to the use of iron-chelating agents in this disease.
URI: http://hdl.handle.net/10553/54226
ISSN: 0163-4453
DOI: 10.1016/S0163-4453(99)90022-1
Fuente: Journal of Infection[ISSN 0163-4453],v. 38, p. 18-21
Colección:Artículos
Vista completa

Citas SCOPUSTM   

15
actualizado el 24-mar-2024

Citas de WEB OF SCIENCETM
Citations

13
actualizado el 25-feb-2024

Visitas

49
actualizado el 10-mar-2024

Google ScholarTM

Verifica

Altmetric


Comparte



Exporta metadatos



Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor con todos los derechos reservados, a menos que se indique lo contrario.