Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/54225
DC Field | Value | Language |
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dc.contributor.author | Peña-Penabad, Carmen | |
dc.contributor.author | De Unamuno, Pablo | |
dc.contributor.author | García Silva, Jesus | |
dc.contributor.author | Ludeña, Ma Dolores | |
dc.contributor.author | González-Sarmiento, Rogelio | |
dc.contributor.author | Pérez-Arellano, Jose Luis | |
dc.date.accessioned | 2019-02-18T09:25:15Z | - |
dc.date.available | 2019-02-18T09:25:15Z | - |
dc.date.issued | 1999 | |
dc.identifier.issn | 1167-1122 | |
dc.identifier.uri | http://hdl.handle.net/10553/54225 | - |
dc.description.abstract | In some cases of lamellar ichthyosis, mutations in the epidermal transglutaminase gene and a reduction in the thickness of the cornified envelope have been documented. Involucrin is a major component of the cornified envelope and a substrate for epidermal transglutaminase, The aim of the present work was to analyse the expression of involucrin in lamellar ichthyosis, An ultrastructural study and/or immunohistochemical and biochemical techniques with anti-involucrin antibody were carried out on the epidermis of fifteen patients (12 families) suffering from lamellar ichthyosis. The effect of in vivo retinoid treatment on the involucrin epidermal expression was also investigated. Four cases with normal skin, seventeen cases of other ichthyoses and ten cases of psoriasis were used as controls. In all these cases of lamellar ichthyosis, a thin or absent cornified envelope, electron-dense granules inside corneocytes and a decrease of the epidermal involucrin expression were observed. In the patients receiving treatment with retinoids, western blot and ELISA revealed an increase in the involucrin expression.The decreased expression of involucrin in lamellar ichthyosis could contribute to the altered desquamation process accompanying the disease, since the clinical improvement associated with retinoid treatment is accompanied by an increase in the expression of involucrin. | |
dc.publisher | 1167-1122 | |
dc.relation.ispartof | European Journal of Dermatology | |
dc.source | European Journal of Dermatology[ISSN 1167-1122],v. 9, p. 197-201 | |
dc.subject.other | Recessive Ichthyosis | |
dc.subject.other | Keratinocyte Transglutaminase | |
dc.subject.other | Monogenic Disorders | |
dc.subject.other | Mutations | |
dc.subject.other | Identification | |
dc.subject.other | Keratinization | |
dc.subject.other | Gene | |
dc.subject.other | Heterogeneity | |
dc.subject.other | Filaggrin | |
dc.subject.other | Envelope | |
dc.title | Altered expression of immunoreactive involucrin in lamellar ichthyosis | |
dc.type | info:eu-repo/semantics/Article | |
dc.type | Article | |
dc.identifier.scopus | 0032928452 | |
dc.identifier.isi | 000079639500005 | |
dc.contributor.authorscopusid | 6603961693 | |
dc.contributor.authorscopusid | 6701808428 | |
dc.contributor.authorscopusid | 7004592007 | |
dc.contributor.authorscopusid | 8778947400 | |
dc.contributor.authorscopusid | 7003610506 | |
dc.contributor.authorscopusid | 7005553929 | |
dc.description.lastpage | 201 | |
dc.description.firstpage | 197 | |
dc.relation.volume | 9 | |
dc.type2 | Artículo | |
dc.contributor.daisngid | 3123571 | |
dc.contributor.daisngid | 2933443 | |
dc.contributor.daisngid | 4694142 | |
dc.contributor.daisngid | 1582522 | |
dc.contributor.daisngid | 147901 | |
dc.contributor.daisngid | 445671 | |
dc.contributor.wosstandard | WOS:Pena-Penabad, C | |
dc.contributor.wosstandard | WOS:de Unamuno, P | |
dc.contributor.wosstandard | WOS:Silva, JG | |
dc.contributor.wosstandard | WOS:Ludena, MD | |
dc.contributor.wosstandard | WOS:Sarmiento, RG | |
dc.contributor.wosstandard | WOS:Perez-Arellano, JL | |
dc.date.coverdate | Abril-Mayo 1999 | |
dc.identifier.ulpgc | Sí | es |
dc.description.jcr | 0,445 | |
dc.description.jcrq | Q4 | |
dc.description.scie | SCIE | |
item.fulltext | Sin texto completo | - |
item.grantfulltext | none | - |
crisitem.author.dept | GIR IUIBS: Trypanosomosis, Resistencia a Antibióticos y Medicina Animal | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Médicas y Quirúrgicas | - |
crisitem.author.orcid | 0000-0002-2936-8242 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Pérez Arellano, José Luis | - |
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