Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/54225
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dc.contributor.authorPeña-Penabad, Carmen
dc.contributor.authorDe Unamuno, Pablo
dc.contributor.authorGarcía Silva, Jesus
dc.contributor.authorLudeña, Ma Dolores
dc.contributor.authorGonzález-Sarmiento, Rogelio
dc.contributor.authorPérez-Arellano, Jose Luis
dc.date.accessioned2019-02-18T09:25:15Z-
dc.date.available2019-02-18T09:25:15Z-
dc.date.issued1999
dc.identifier.issn1167-1122
dc.identifier.urihttp://hdl.handle.net/10553/54225-
dc.description.abstractIn some cases of lamellar ichthyosis, mutations in the epidermal transglutaminase gene and a reduction in the thickness of the cornified envelope have been documented. Involucrin is a major component of the cornified envelope and a substrate for epidermal transglutaminase, The aim of the present work was to analyse the expression of involucrin in lamellar ichthyosis, An ultrastructural study and/or immunohistochemical and biochemical techniques with anti-involucrin antibody were carried out on the epidermis of fifteen patients (12 families) suffering from lamellar ichthyosis. The effect of in vivo retinoid treatment on the involucrin epidermal expression was also investigated. Four cases with normal skin, seventeen cases of other ichthyoses and ten cases of psoriasis were used as controls. In all these cases of lamellar ichthyosis, a thin or absent cornified envelope, electron-dense granules inside corneocytes and a decrease of the epidermal involucrin expression were observed. In the patients receiving treatment with retinoids, western blot and ELISA revealed an increase in the involucrin expression.The decreased expression of involucrin in lamellar ichthyosis could contribute to the altered desquamation process accompanying the disease, since the clinical improvement associated with retinoid treatment is accompanied by an increase in the expression of involucrin.
dc.publisher1167-1122
dc.relation.ispartofEuropean Journal of Dermatology
dc.sourceEuropean Journal of Dermatology[ISSN 1167-1122],v. 9, p. 197-201
dc.subject.otherRecessive Ichthyosis
dc.subject.otherKeratinocyte Transglutaminase
dc.subject.otherMonogenic Disorders
dc.subject.otherMutations
dc.subject.otherIdentification
dc.subject.otherKeratinization
dc.subject.otherGene
dc.subject.otherHeterogeneity
dc.subject.otherFilaggrin
dc.subject.otherEnvelope
dc.titleAltered expression of immunoreactive involucrin in lamellar ichthyosis
dc.typeinfo:eu-repo/semantics/Article
dc.typeArticle
dc.identifier.scopus0032928452
dc.identifier.isi000079639500005
dc.contributor.authorscopusid6603961693
dc.contributor.authorscopusid6701808428
dc.contributor.authorscopusid7004592007
dc.contributor.authorscopusid8778947400
dc.contributor.authorscopusid7003610506
dc.contributor.authorscopusid7005553929
dc.description.lastpage201
dc.description.firstpage197
dc.relation.volume9
dc.type2Artículo
dc.contributor.daisngid3123571
dc.contributor.daisngid2933443
dc.contributor.daisngid4694142
dc.contributor.daisngid1582522
dc.contributor.daisngid147901
dc.contributor.daisngid445671
dc.contributor.wosstandardWOS:Pena-Penabad, C
dc.contributor.wosstandardWOS:de Unamuno, P
dc.contributor.wosstandardWOS:Silva, JG
dc.contributor.wosstandardWOS:Ludena, MD
dc.contributor.wosstandardWOS:Sarmiento, RG
dc.contributor.wosstandardWOS:Perez-Arellano, JL
dc.date.coverdateAbril-Mayo 1999
dc.identifier.ulpgces
dc.description.jcr0,445
dc.description.jcrqQ4
dc.description.scieSCIE
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptGIR IUIBS: Trypanosomosis, Resistencia a Antibióticos y Medicina Animal-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.orcid0000-0002-2936-8242-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNamePérez Arellano, José Luis-
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