Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/53601
Título: Induced expression of pattern recognition receptors in cumulus oocyte complexes: Novel evidence for innate immune-like functions during ovulation
Autores/as: Shimada, Masayuki
Hernandez-Gonzalez, Inmaculada 
Gonzalez-Robanya, Ignacio
Richards, JoAnne S.
Palabras clave: Rat Preovulatory Follicles
Toll-Like Receptors
Granulosa-Cells
Scavenger Receptor
Gene-Expression, et al.
Fecha de publicación: 2006
Editor/a: 0888-8809
Publicación seriada: Molecular Endocrinology 
Resumen: Ovulation is the complex, inflammatory-like process by which the cumulus oocyte complex (COC) is released from a mature, preovulatory follicle through a rupture site at the ovarian surface and requires expression of genes that generate and stabilize the expanded extracellular COC matrix. Gene profiling analyses of COCs at selected time intervals during ovulation revealed that many genes associated with immune related surveillance functions were also induced in cumulus cells. Specifically, cell surface signaling molecules known as pattern recognition receptors that act as sensors of the external environment important for the innate immune system to detect self from nonself or altered self are induced and/or expressed in cumulus cells as well as granulosa cells. These include the complement factor q1, CD14, and the Toll-like receptors (TLRs) 4, 8, and 9 as well as mediators of TLR activation, myeloid differentiation primary response gene 88 and interferon regulatory factor 3. COCs exposed to bacterial lipopolysaccharide exhibit enhanced phosphorylation of p38MAPK, ERK1/2 and nuclear factor-kappa B and increased expression of II6 and Tnfa target genes, documenting that the TLR pathway is functional. Cumulus cells and granulosa cells also express the scavenger receptors CD36 and scavenger receptor type B1 and exhibited phagocytic uptake of fluorescently tagged bacterial particles. Collectively, these results provide novel evidence that cumulus cells as well as granulosa cells express innate immune related genes that may play critical roles in surveillance and cell survival during the ovulation process.
URI: http://hdl.handle.net/10553/53601
ISSN: 0888-8809
DOI: 10.1210/me.2006-0194
Fuente: Molecular Endocrinology[ISSN 0888-8809],v. 20 (12), p. 3228-3239
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