Identificador persistente para citar o vincular este elemento: http://hdl.handle.net/10553/53519
Campo DC Valoridioma
dc.contributor.authorNicolini, Fabioen_US
dc.contributor.authorBurmistrova, Olgaen_US
dc.contributor.authorMarrero, Maria Teresaen_US
dc.contributor.authorTorres, Fernandoen_US
dc.contributor.authorHernandez, Cristinaen_US
dc.contributor.authorQuintana, Joseen_US
dc.contributor.authorEstevez, Franciscoen_US
dc.contributor.otherQuintana, Jose-
dc.contributor.otherEstevez, Francisco-
dc.contributor.otherTorres Andon, Fernando-
dc.date.accessioned2019-02-04T17:01:22Z-
dc.date.available2019-02-04T17:01:22Z-
dc.date.issued2014en_US
dc.identifier.issn0899-1987en_US
dc.identifier.urihttp://hdl.handle.net/10553/53519-
dc.description.abstractFlavonoids are naturally occurring polyphenolic compounds which display a vast array of biological activities. In this study, we investigated the effects of tamarixetin on viability of human tumor cell lines and found that it was cytotoxic against leukemia cells and in particular P‐glycoprotein‐overexpressing K562/ADR cells. This compound inhibited proliferation in a concentration‐ and time‐dependent manner, induced apoptosis and blocked cell cycle progression at G2‐M phase. This was associated with the accumulation of cyclin B1, Bub1 and p21Cip1/Waf‐1, changes in the phosphorylation status of cyclin B1, Cdk1, Cdc25C and MPM‐2, and inhibition of tubulin polymerization. Moreover, cell death was found to be associated with cytochrome c release and cleavage of caspases and of poly(ADP‐ribose) polymerase, and completely abrogated by the free‐radical scavenger N‐acetyl‐L‐cysteine. The sensitivity of leukemic cells to tamarixetin suggests that it should be considered for further preclinical and in vivo testing.en_US
dc.languageengen_US
dc.relationEvaluación de Potenciales Compuestos Antileucémicos.en_US
dc.relation.ispartofMolecular Carcinogenesisen_US
dc.sourceMolecular Carcinogenesis [ISSN 0899-1987], v. 53 (12), p. 939-950en_US
dc.subject3205 Medicina internaen_US
dc.subject.otherApoptosisen_US
dc.subject.otherFlavonoidsen_US
dc.subject.otherCell cycle arresten_US
dc.titleInduction of G(2)/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cellsen_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1002/mc.22055en_US
dc.identifier.scopus84911420590-
dc.identifier.isi000344396400001-
dcterms.isPartOfMolecular Carcinogenesis-
dcterms.sourceMolecular Carcinogenesis[ISSN 0899-1987],v. 53 (12), p. 939-950-
dc.contributor.authorscopusid55762306700-
dc.contributor.authorscopusid54396785700-
dc.contributor.authorscopusid55055343200-
dc.contributor.authorscopusid55366045300-
dc.contributor.authorscopusid55762485600-
dc.contributor.authorscopusid8681043500-
dc.contributor.authorscopusid7003810011-
dc.description.lastpage950en_US
dc.identifier.issue12-
dc.description.firstpage939en_US
dc.relation.volume53en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000344396400001-
dc.contributor.daisngid9430865-
dc.contributor.daisngid4152189-
dc.contributor.daisngid2743847-
dc.contributor.daisngid2952604-
dc.contributor.daisngid34941095-
dc.contributor.daisngid125177-
dc.contributor.daisngid128315-
dc.contributor.daisngid384944-
dc.identifier.investigatorRIDK-5709-2014-
dc.identifier.investigatorRIDK-5125-2014-
dc.identifier.investigatorRIDNo ID-
dc.description.numberofpages12en_US
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Nicolini, F-
dc.contributor.wosstandardWOS:Burmistrova, O-
dc.contributor.wosstandardWOS:Marrero, MT-
dc.contributor.wosstandardWOS:Torres, F-
dc.contributor.wosstandardWOS:Hernandez, C-
dc.contributor.wosstandardWOS:Quintana, J-
dc.contributor.wosstandardWOS:Estevez, F-
dc.date.coverdateDiciembre 2014en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,648-
dc.description.jcr4,808-
dc.description.sjrqQ1-
dc.description.jcrqQ1-
dc.description.scieSCIE-
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.project.principalinvestigatorEstévez Rosas, Francisco Jesús-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Bioquímica-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0001-8225-4538-
crisitem.author.orcid0000-0002-9728-2774-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameQuintana Aguiar, José Martín-
crisitem.author.fullNameEstévez Rosas, Francisco Jesús-
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