Identificador persistente para citar o vincular este elemento:
http://hdl.handle.net/10553/53519
Campo DC | Valor | idioma |
---|---|---|
dc.contributor.author | Nicolini, Fabio | en_US |
dc.contributor.author | Burmistrova, Olga | en_US |
dc.contributor.author | Marrero, Maria Teresa | en_US |
dc.contributor.author | Torres, Fernando | en_US |
dc.contributor.author | Hernandez, Cristina | en_US |
dc.contributor.author | Quintana, Jose | en_US |
dc.contributor.author | Estevez, Francisco | en_US |
dc.contributor.other | Quintana, Jose | - |
dc.contributor.other | Estevez, Francisco | - |
dc.contributor.other | Torres Andon, Fernando | - |
dc.date.accessioned | 2019-02-04T17:01:22Z | - |
dc.date.available | 2019-02-04T17:01:22Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.issn | 0899-1987 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/53519 | - |
dc.description.abstract | Flavonoids are naturally occurring polyphenolic compounds which display a vast array of biological activities. In this study, we investigated the effects of tamarixetin on viability of human tumor cell lines and found that it was cytotoxic against leukemia cells and in particular P‐glycoprotein‐overexpressing K562/ADR cells. This compound inhibited proliferation in a concentration‐ and time‐dependent manner, induced apoptosis and blocked cell cycle progression at G2‐M phase. This was associated with the accumulation of cyclin B1, Bub1 and p21Cip1/Waf‐1, changes in the phosphorylation status of cyclin B1, Cdk1, Cdc25C and MPM‐2, and inhibition of tubulin polymerization. Moreover, cell death was found to be associated with cytochrome c release and cleavage of caspases and of poly(ADP‐ribose) polymerase, and completely abrogated by the free‐radical scavenger N‐acetyl‐L‐cysteine. The sensitivity of leukemic cells to tamarixetin suggests that it should be considered for further preclinical and in vivo testing. | en_US |
dc.language | eng | en_US |
dc.relation | Evaluación de Potenciales Compuestos Antileucémicos. | en_US |
dc.relation.ispartof | Molecular Carcinogenesis | en_US |
dc.source | Molecular Carcinogenesis [ISSN 0899-1987], v. 53 (12), p. 939-950 | en_US |
dc.subject | 3205 Medicina interna | en_US |
dc.subject.other | Apoptosis | en_US |
dc.subject.other | Flavonoids | en_US |
dc.subject.other | Cell cycle arrest | en_US |
dc.title | Induction of G(2)/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1002/mc.22055 | en_US |
dc.identifier.scopus | 84911420590 | - |
dc.identifier.isi | 000344396400001 | - |
dcterms.isPartOf | Molecular Carcinogenesis | - |
dcterms.source | Molecular Carcinogenesis[ISSN 0899-1987],v. 53 (12), p. 939-950 | - |
dc.contributor.authorscopusid | 55762306700 | - |
dc.contributor.authorscopusid | 54396785700 | - |
dc.contributor.authorscopusid | 55055343200 | - |
dc.contributor.authorscopusid | 55366045300 | - |
dc.contributor.authorscopusid | 55762485600 | - |
dc.contributor.authorscopusid | 8681043500 | - |
dc.contributor.authorscopusid | 7003810011 | - |
dc.description.lastpage | 950 | en_US |
dc.identifier.issue | 12 | - |
dc.description.firstpage | 939 | en_US |
dc.relation.volume | 53 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000344396400001 | - |
dc.contributor.daisngid | 9430865 | - |
dc.contributor.daisngid | 4152189 | - |
dc.contributor.daisngid | 2743847 | - |
dc.contributor.daisngid | 2952604 | - |
dc.contributor.daisngid | 34941095 | - |
dc.contributor.daisngid | 125177 | - |
dc.contributor.daisngid | 128315 | - |
dc.contributor.daisngid | 384944 | - |
dc.identifier.investigatorRID | K-5709-2014 | - |
dc.identifier.investigatorRID | K-5125-2014 | - |
dc.identifier.investigatorRID | No ID | - |
dc.description.numberofpages | 12 | en_US |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Nicolini, F | - |
dc.contributor.wosstandard | WOS:Burmistrova, O | - |
dc.contributor.wosstandard | WOS:Marrero, MT | - |
dc.contributor.wosstandard | WOS:Torres, F | - |
dc.contributor.wosstandard | WOS:Hernandez, C | - |
dc.contributor.wosstandard | WOS:Quintana, J | - |
dc.contributor.wosstandard | WOS:Estevez, F | - |
dc.date.coverdate | Diciembre 2014 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.sjr | 1,648 | - |
dc.description.jcr | 4,808 | - |
dc.description.sjrq | Q1 | - |
dc.description.jcrq | Q1 | - |
dc.description.scie | SCIE | - |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.project.principalinvestigator | Estévez Rosas, Francisco Jesús | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.dept | GIR IUIBS: Bioquímica | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.orcid | 0000-0001-8225-4538 | - |
crisitem.author.orcid | 0000-0002-9728-2774 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Quintana Aguiar, José Martín | - |
crisitem.author.fullName | Estévez Rosas, Francisco Jesús | - |
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