|Title:||Skeletal muscle IL-15/IL-15Rα and myofibrillar protein synthesis after resistance exercise||Authors:||Perez-Lopez, A.
Morales Álamo, David
Calbet, Jose A.
|UNESCO Clasification:||241106 Fisiología del ejercicio||Keywords:||Myokines
Muscle protein synthesis/breakdown
|Issue Date:||2018||Project:||Viabilidad y sostenibilidad del adelgazamiento mediante tratamiento intensificado en pacientes con sobrepeso u obesidad: mecanismos neuroendocrinos y moleculares||Journal:||Scandinavian Journal of Medicine and Science in Sports||Abstract:||In vitro and in vivo studies described the myokine IL-15 and its receptor IL-15R as anabolic/anti-atrophy agents, however, the protein expression of IL-15R has not been measured in human skeletal muscle and data regarding IL-15 expression remain inconclusive. The purpose of the study was to determine serum and skeletal muscle IL-15 and IL-15R responses to resistance exercise session and to analyze their association with myofibrillar protein synthesis (MPS). Fourteen participants performed a bilateral leg resistance exercise composed of four sets of leg press and four sets of knee extension at 75% 1RM to task failure. Muscle biopsies were obtained at rest, 0, 4 and 24hours post-exercise and blood samples at rest, mid-exercise, 0, 0.3, 1, 2, 4 and 24hours post-exercise. Serum IL-15 was increased by similar to 5.3-fold immediately post-exercise, while serum IL-15R decreased similar to 75% over 1hour post-exercise (P<.001). Skeletal muscle IL-15R mRNA and protein expression were increased at 4hours post-exercise by similar to 2-fold (P<.001) and similar to 1.3-fold above rest (P=.020), respectively. At 24hours post-exercise, IL-15 (P=.003) and IL-15R mRNAs increased by similar to 2-fold (P=.002). Myofibrillar fractional synthetic rate between 0-4hours was associated with IL-15R mRNA at rest (r=.662, P=.019), 4hours (r=.612, P=.029), and 24hours post-exercise (r=.627, P=.029). Finally, the muscle IL-15R protein up-regulation was related to Leg press 1RM (r=.688, P=.003) and total weight lifted (r=.628, P=.009). In conclusion, IL-15/IL-15R signaling pathway is activated in skeletal muscle in response to a session of resistance exercise.||URI:||http://hdl.handle.net/10553/41815||ISSN:||0905-7188||DOI:||10.1111/sms.12901||Source:||Scandinavian Journal of Medicine and Science in Sports [ISSN 0905-7188], v. 28 (1), p. 116-125|
|Appears in Collections:||Artículos|
checked on May 16, 2021
WEB OF SCIENCETM
checked on May 9, 2021
checked on May 17, 2021
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.