Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/53387
DC FieldValueLanguage
dc.contributor.authorJones, Andrew M.
dc.contributor.authorKrustrup, Peter
dc.contributor.authorWilkerson, Daryl P.
dc.contributor.authorBerger, Nicolas J.
dc.contributor.authorCalbet, Jose A.
dc.contributor.authorBangsbo, Jens
dc.contributor.otherCalbet, Jose A
dc.contributor.otherKrustrup, Peter
dc.contributor.otherBangsbo, Jens
dc.date.accessioned2019-02-04T16:24:58Z-
dc.date.available2019-02-04T16:24:58Z-
dc.date.issued2012
dc.identifier.issn0022-3751
dc.identifier.urihttp://hdl.handle.net/10553/53387-
dc.description.abstractKey points Following the start of low-intensity exercise in healthy humans, it has been established that the kinetics of muscle O2 delivery is faster than, and does not limit, the kinetics of muscle O2 uptake. Direct data are lacking, however, on the question of whether O2 delivery might limit O2 uptake kinetics during high-intensity exercise. In this study, we made frequent measurements of muscle blood flow, arterial-to-venous O2 difference (adifference) and O2 uptake following the onset of multiple transitions of both low-intensity and high-intensity knee-extension exercise in the same subjects. We show that although blood flow kinetics is slower for high-intensity compared with low-intensity exercise, this does not result in slower O2 uptake kinetics. These results indicate that muscle O2 delivery does not limit O2 uptake during knee-extension exercise in healthy humans. Abstract Following the start of low-intensity exercise in healthy humans, it has been established that the kinetics of skeletal muscle O2 delivery is faster than, and does not limit, the kinetics of muscle O2 uptake (). Direct data are lacking, however, on the question of whether O2 delivery might limit kinetics during high-intensity exercise. Using multiple exercise transitions to enhance confidence in parameter estimation, we therefore investigated the kinetics of, and inter-relationships between, muscle blood flow (), a difference and following the onset of low-intensity (LI) and high-intensity (HI) exercise. Seven healthy males completed four 6 min bouts of LI and four 6 min bouts of HI single-legged knee-extension exercise. Blood was frequently drawn from the femoral artery and vein during exercise and , a difference and were calculated and subsequently modelled using non-linear regression techniques. For LI, the fundamental component mean response time (MRTp) for kinetics was significantly shorter than kinetics (mean +/- SEM, 18 +/- 4 vs. 30 +/- 4 s; P < 0.05), whereas for HI, the MRTp for and was not significantly different (27 +/- 5 vs. 29 +/- 4 s, respectively). There was no difference in the MRTp for either or between the two exercise intensities; however, the MRTp for a difference was significantly shorter for HI compared with LI (17 +/- 3 vs. 28 +/- 4 s; P < 0.05). Excess O2, i.e. oxygen not taken up (x), was significantly elevated within the first 5 s of exercise and remained unaltered thereafter, with no differences between LI and HI. These results indicate that bulk O2 delivery does not limit kinetics following the onset of LI or HI knee-extension exercise.
dc.publisher0022-3751
dc.relation.ispartofJournal of Physiology
dc.sourceJournal Of Physiology-London[ISSN 0022-3751],v. 590 (17), p. 4363-4376
dc.subject.otherOxygen-Uptake Kinetics
dc.subject.otherO-2 Uptake Kinetics
dc.subject.otherKnee-Extensor Exercise
dc.subject.otherSubmaximal Exercise
dc.subject.otherDynamic Exercise
dc.subject.otherNeuromuscular Blockade
dc.subject.otherRat Muscles
dc.subject.otherHeavy
dc.subject.otherOnset
dc.subject.otherPulmonary
dc.titleInfluence of exercise intensity on skeletal muscle blood flow, O2 extraction and O2 uptake on-kinetics
dc.typeinfo:eu-repo/semantics/Article
dc.typeArticle
dc.identifier.doi10.1113/jphysiol.2012.233064
dc.identifier.scopus84865576632
dc.identifier.isi000308095900024
dcterms.isPartOfJournal Of Physiology-London
dcterms.sourceJournal Of Physiology-London[ISSN 0022-3751],v. 590 (17), p. 4363-4376
dc.contributor.authorscopusid7407101756
dc.contributor.authorscopusid6603882135
dc.contributor.authorscopusid7007100235
dc.contributor.authorscopusid9040873600
dc.contributor.authorscopusid7004323423
dc.contributor.authorscopusid7006071456
dc.description.lastpage4376
dc.identifier.issue17
dc.description.firstpage4363
dc.relation.volume590
dc.type2Artículo
dc.identifier.wosWOS:000308095900024
dc.contributor.daisngid52744
dc.contributor.daisngid82648
dc.contributor.daisngid468702
dc.contributor.daisngid1218036
dc.contributor.daisngid90295
dc.contributor.daisngid58446
dc.identifier.investigatorRIDH-6693-2015
dc.identifier.investigatorRIDNo ID
dc.identifier.investigatorRIDNo ID
dc.contributor.wosstandardWOS:Jones, AM
dc.contributor.wosstandardWOS:Krustrup, P
dc.contributor.wosstandardWOS:Wilkerson, DP
dc.contributor.wosstandardWOS:Berger, NJ
dc.contributor.wosstandardWOS:Calbet, JA
dc.contributor.wosstandardWOS:Bangsbo, J
dc.date.coverdateSeptiembre 2012
dc.identifier.ulpgces
dc.description.sjr2,562
dc.description.jcr4,38
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptGIR IUIBS: Rendimiento humano, ejercicio físico y salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Educación Física-
crisitem.author.orcid0000-0002-9215-6234-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameLópez Calbet, José Antonio-
Appears in Collections:Artículos
Show simple item record

SCOPUSTM   
Citations

24
checked on Aug 7, 2022

WEB OF SCIENCETM
Citations

26
checked on Jun 5, 2022

Page view(s)

11
checked on Jul 30, 2022

Google ScholarTM

Check

Altmetric


Share



Export metadata



Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.