Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/52626
DC FieldValueLanguage
dc.contributor.authorDonat, Esteren_US
dc.contributor.authorGarcía Ramos, J. M.en_US
dc.contributor.authorSánchez-Valverde, Félixen_US
dc.contributor.authorMoreno, Anaen_US
dc.contributor.authorMartinez, M.-J.en_US
dc.contributor.authorLeis, Rosauraen_US
dc.contributor.authorPeña-Quintana, Luisen_US
dc.contributor.authorCastillejo, Gemmaen_US
dc.contributor.authorGarrote Fernández, Soniaen_US
dc.contributor.authorGarcia, Zuriñeen_US
dc.contributor.authorOrtigosa, Luísen_US
dc.contributor.authorBalmaseda, Elenaen_US
dc.contributor.authorMarugán, José Manuelen_US
dc.contributor.authorEizaguirre, Francisco Javieren_US
dc.contributor.authorLorenzo, Helenaen_US
dc.contributor.authorBarrio, Josefaen_US
dc.contributor.authorRibes-Koninckx, Carmenen_US
dc.date.accessioned2018-12-05T10:42:45Z-
dc.date.available2018-12-05T10:42:45Z-
dc.date.issued2016en_US
dc.identifier.issn0277-2116en_US
dc.identifier.urihttp://hdl.handle.net/10553/52626-
dc.description.abstractObjectives: A large retrospective multicentre study was conducted in Spain to evaluate the efficiency of the new European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) criteria for the diagnosis of coeliac disease (CD). Methods: The study protocol was approved by the ethics committee of Hospital Universitari i Politècnic La Fe (Valencia, Spain). The present study included 2177 children (ages 0.6-15.9 years) with small bowel biopsy (SBB) performed for diagnostic purposes (from 2000 to 2009) and with a minimum 2-year follow-up after biopsy. Results: CD was diagnosed in 2126 patients (97.5%) and excluded in 51 (2.5%). Tissue transglutaminase antibodies (TG2A), anti-endomysial antibodies (EMA), and human leukocyte antigen (HLA) were reported in 751 patients, 640 symptomatic and 111 asymptomatic. TG2A levels >10 times the upper limit of normal, plus positive EMA and HLA DQ2 and/or DQ8 haplotypes, were found in 336 symptomatic patients, all of them with final diagnosis of CD. In 65 of 69 asymptomatic patients, 65 had confirmed CD and 4 did not have CD. According to the 2012 ESPGHAN guidelines, SBB may have been omitted in 52% of the symptomatic patients with CD with serologic and HLA available data. Gluten challenge was performed in 158 children, 75 of them <2 years at first biopsy. Only 1 patient in whom according to the new proposed diagnostic criteria gluten challenge would not have been mandatory did not relapse. Conclusions: Our results support the new ESPGHAN 2012 guidelines for diagnosis of CD can be safely used without the risk of overdiagnosis. A prospective multicentre study is needed to confirm our results.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutritionen_US
dc.sourceJournal of Pediatric Gastroenterology and Nutrition[ISSN 0277-2116],v. 62, p. 284-291en_US
dc.subject3206 Ciencias de la nutriciónen_US
dc.subject.otherCeliac diseaseen_US
dc.subject.otherChildrenen_US
dc.subject.otherESPGHAN 2012 diagnostic criteriaen_US
dc.subject.otherSpanishen_US
dc.titleESPGHAN 2012 guidelines for coeliac disease diagnosis: validation through a retrospective spanish multicentric studyen_US
dc.typeinfo:eu-repo/semantics/Articlees
dc.typeArticlees
dc.identifier.doi10.1097/MPG.0000000000000870
dc.identifier.scopus84957102186
dc.identifier.isi000369292300005
dc.contributor.authorscopusid24467378400
dc.contributor.authorscopusid57095363300
dc.contributor.authorscopusid6602698339
dc.contributor.authorscopusid57206906189
dc.contributor.authorscopusid56452258900
dc.contributor.authorscopusid55220238900
dc.contributor.authorscopusid57213207714
dc.contributor.authorscopusid6602267884
dc.contributor.authorscopusid6603266503
dc.contributor.authorscopusid14631687000
dc.contributor.authorscopusid57200704507
dc.contributor.authorscopusid56275101000
dc.contributor.authorscopusid54946469200
dc.contributor.authorscopusid16315287100
dc.contributor.authorscopusid8516378500
dc.contributor.authorscopusid54388779500
dc.contributor.authorscopusid57095660900
dc.contributor.authorscopusid36658843400
dc.contributor.authorscopusid6602108756
dc.description.lastpage291-
dc.identifier.issue2-
dc.description.firstpage284-
dc.relation.volume62-
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.contributor.daisngid1743929
dc.contributor.daisngid11177661
dc.contributor.daisngid2119990
dc.contributor.daisngid30406991
dc.contributor.daisngid30065455
dc.contributor.daisngid607405
dc.contributor.daisngid1012004
dc.contributor.daisngid1170900
dc.contributor.daisngid5187915
dc.contributor.daisngid6909421
dc.contributor.daisngid1113114
dc.contributor.daisngid5951198
dc.contributor.daisngid4051683
dc.contributor.daisngid6379182
dc.contributor.daisngid6530595
dc.contributor.daisngid6748214
dc.contributor.daisngid629698
dc.contributor.wosstandardWOS:Donat, E
dc.contributor.wosstandardWOS:Ramos, JM
dc.contributor.wosstandardWOS:Sanchez-Valverde, F
dc.contributor.wosstandardWOS:Moreno, A
dc.contributor.wosstandardWOS:Martinez, MJ
dc.contributor.wosstandardWOS:Leis, R
dc.contributor.wosstandardWOS:Pena-Quintana, L
dc.contributor.wosstandardWOS:Castillejo, G
dc.contributor.wosstandardWOS:Fernandez, S
dc.contributor.wosstandardWOS:Garcia, Z
dc.contributor.wosstandardWOS:Ortigosa, L
dc.contributor.wosstandardWOS:Balmaseda, E
dc.contributor.wosstandardWOS:Marugan, JM
dc.contributor.wosstandardWOS:Eizaguirre, FJ
dc.contributor.wosstandardWOS:Lorenzo, H
dc.contributor.wosstandardWOS:Barrio, J
dc.contributor.wosstandardWOS:Ribes-Koninckx, C
dc.date.coverdateFebrero 2016
dc.identifier.ulpgces
dc.description.sjr1,24
dc.description.jcr2,799
dc.description.sjrqQ1
dc.description.jcrqQ1
item.fulltextSin texto completo-
item.grantfulltextnone-
crisitem.author.deptNutrición-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.orcid0000-0001-6052-5894-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNamePeña Quintana, Luis-
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