Please use this identifier to cite or link to this item: http://hdl.handle.net/10553/52603
DC FieldValueLanguage
dc.contributor.authorFigueroa Rivero, Javieren_US
dc.contributor.authorHenríquez-Hernández, Luis Albertoen_US
dc.contributor.authorLuzardo, Octavio P.en_US
dc.contributor.authorPestano, Joséen_US
dc.contributor.authorZumbado, Manuelen_US
dc.contributor.authorBoada, Luis D.en_US
dc.contributor.authorValerón, Pilar F.en_US
dc.contributor.otherZumbado, Manuel-
dc.contributor.otherPestano Brito, Jose Juan-
dc.contributor.otherHenriquez-Hernandez, Luis Alberto-
dc.date.accessioned2018-12-04T16:41:46Z-
dc.date.available2018-12-04T16:41:46Z-
dc.date.issued2016en_US
dc.identifier.issn0378-4274en_US
dc.identifier.urihttp://hdl.handle.net/10553/52603-
dc.description.abstractOrganochlorine pesticides (OCs) have been associated with breast cancer development and progression, but the mechanisms underlying this phenomenon are not well known. In this work, we evaluated the effects exerted on normal human mammary epithelial cells (HMEC) by the OC mixtures most frequently detected in healthy women (H-mixture) and in women diagnosed with breast cancer (BC-mixture), as identified in a previous case-control study developed in Spain. Cytotoxicity and gene expression profile of human kinases (= 68) and non-kinases (= 26) were tested at concentrations similar to those described in the serum of those cases and controls. Although both mixtures caused a down-regulation of genes involved in the ATP binding process, our results clearly indicate that both mixtures may exert a very different effect on the gene expression profile of HMEC. Thus, while BC-mixture up-regulated the expression of oncogenes associated to breast cancer (GFRA1 and BHLHB8), the H-mixture down-regulated the expression of tumor suppressor genes (EPHA4 and EPHB2). Our results indicate that the composition of the OC mixture could play a role in the initiation processes of breast cancer. In addition, the present results suggest that subtle changes in the composition and levels of pollutants involved in environmentally relevant mixtures might induce very different biological effects, which explain, at least partially, why some mixtures seem to be more carcinogenic than others. Nonetheless, our findings confirm that environmentally relevant pollutants may modulate the expression of genes closely related to carcinogenic processes in the breast, reinforcing the role exerted by environment in the regulation of genes involved in breast carcinogenesis.en_US
dc.languageengen_US
dc.relation.ispartofToxicology Lettersen_US
dc.sourceToxicology Letters[ISSN 0378-4274],v. 246, p. 42-48en_US
dc.subject3214 Toxicologíaen_US
dc.subject320101 Oncologíaen_US
dc.subject.otherBreast canceren_US
dc.subject.otherGene expressionen_US
dc.subject.otherHMECen_US
dc.subject.otherOrganochlorine mixturesen_US
dc.subject.otherXenoestrogensen_US
dc.titleDifferential gene expression pattern in human mammary epithelial cells induced by realistic organochlorine mixtures described in healthy women and in women diagnosed with breast canceren_US
dc.typeinfo:eu-repo/semantics/Articleen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.toxlet.2016.02.003en_US
dc.identifier.scopus84957831403-
dc.identifier.isi000370525300006-
dcterms.isPartOfToxicology Letters
dcterms.sourceToxicology Letters[ISSN 0378-4274],v. 246, p. 42-48
dc.contributor.authorscopusid56830230000-
dc.contributor.authorscopusid15829708200-
dc.contributor.authorscopusid6507534124-
dc.contributor.authorscopusid56149756400-
dc.contributor.authorscopusid6603459604-
dc.contributor.authorscopusid6603916807-
dc.contributor.authorscopusid6603469417-
dc.description.lastpage48en_US
dc.description.firstpage42en_US
dc.relation.volume246en_US
dc.investigacionCiencias de la Saluden_US
dc.type2Artículoen_US
dc.identifier.wosWOS:000370525300006-
dc.contributor.daisngid27812108-
dc.contributor.daisngid465624-
dc.contributor.daisngid418704-
dc.contributor.daisngid865329-
dc.contributor.daisngid418822-
dc.contributor.daisngid1656886-
dc.contributor.daisngid1146740-
dc.identifier.investigatorRIDB-4495-2010-
dc.identifier.investigatorRIDA-9640-2017-
dc.identifier.investigatorRIDNo ID-
dc.utils.revisionen_US
dc.contributor.wosstandardWOS:Rivero, J-
dc.contributor.wosstandardWOS:Henriquez-Hernandez, LA-
dc.contributor.wosstandardWOS:Luzardo, OP-
dc.contributor.wosstandardWOS:Pestano, J-
dc.contributor.wosstandardWOS:Zumbado, M-
dc.contributor.wosstandardWOS:Boada, LD-
dc.contributor.wosstandardWOS:Valeron, PF-
dc.date.coverdateMarzo 2016en_US
dc.identifier.ulpgcen_US
dc.contributor.buulpgcBU-MEDen_US
dc.description.sjr1,25
dc.description.jcr3,858
dc.description.sjrqQ1
dc.description.jcrqQ1
dc.description.scieSCIE
item.grantfulltextnone-
item.fulltextSin texto completo-
crisitem.author.deptDepartamento de Ciencias Médicas y Quirúrgicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Ciencias Clínicas-
crisitem.author.deptGIR IUIBS: Medio Ambiente y Salud-
crisitem.author.deptIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.deptDepartamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología-
crisitem.author.orcid0000-0003-3237-0316-
crisitem.author.orcid0000-0002-4153-3028-
crisitem.author.orcid0000-0001-6454-4785-
crisitem.author.orcid0000-0002-1534-7758-
crisitem.author.orcid0000-0002-0195-4565-
crisitem.author.orcid0000-0001-5865-7003-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.parentorgIU de Investigaciones Biomédicas y Sanitarias-
crisitem.author.fullNameFigueroa Rivero, Javier-
crisitem.author.fullNameHenríquez Hernández, Luis Alberto-
crisitem.author.fullNamePérez Luzardo, Octavio Luis-
crisitem.author.fullNamePestano Brito, José Juan-
crisitem.author.fullNameZumbado Peña, Manuel Luis-
crisitem.author.fullNameDomínguez Boada, Luis María-
crisitem.author.fullNameFernández Valerón, Josefa Pilar-
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