Please use this identifier to cite or link to this item:
http://hdl.handle.net/10553/52603
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Figueroa Rivero, Javier | en_US |
dc.contributor.author | Henríquez-Hernández, Luis Alberto | en_US |
dc.contributor.author | Luzardo, Octavio P. | en_US |
dc.contributor.author | Pestano, José | en_US |
dc.contributor.author | Zumbado, Manuel | en_US |
dc.contributor.author | Boada, Luis D. | en_US |
dc.contributor.author | Valerón, Pilar F. | en_US |
dc.contributor.other | Zumbado, Manuel | - |
dc.contributor.other | Pestano Brito, Jose Juan | - |
dc.contributor.other | Henriquez-Hernandez, Luis Alberto | - |
dc.date.accessioned | 2018-12-04T16:41:46Z | - |
dc.date.available | 2018-12-04T16:41:46Z | - |
dc.date.issued | 2016 | en_US |
dc.identifier.issn | 0378-4274 | en_US |
dc.identifier.uri | http://hdl.handle.net/10553/52603 | - |
dc.description.abstract | Organochlorine pesticides (OCs) have been associated with breast cancer development and progression, but the mechanisms underlying this phenomenon are not well known. In this work, we evaluated the effects exerted on normal human mammary epithelial cells (HMEC) by the OC mixtures most frequently detected in healthy women (H-mixture) and in women diagnosed with breast cancer (BC-mixture), as identified in a previous case-control study developed in Spain. Cytotoxicity and gene expression profile of human kinases (= 68) and non-kinases (= 26) were tested at concentrations similar to those described in the serum of those cases and controls. Although both mixtures caused a down-regulation of genes involved in the ATP binding process, our results clearly indicate that both mixtures may exert a very different effect on the gene expression profile of HMEC. Thus, while BC-mixture up-regulated the expression of oncogenes associated to breast cancer (GFRA1 and BHLHB8), the H-mixture down-regulated the expression of tumor suppressor genes (EPHA4 and EPHB2). Our results indicate that the composition of the OC mixture could play a role in the initiation processes of breast cancer. In addition, the present results suggest that subtle changes in the composition and levels of pollutants involved in environmentally relevant mixtures might induce very different biological effects, which explain, at least partially, why some mixtures seem to be more carcinogenic than others. Nonetheless, our findings confirm that environmentally relevant pollutants may modulate the expression of genes closely related to carcinogenic processes in the breast, reinforcing the role exerted by environment in the regulation of genes involved in breast carcinogenesis. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Toxicology Letters | en_US |
dc.source | Toxicology Letters[ISSN 0378-4274],v. 246, p. 42-48 | en_US |
dc.subject | 3214 Toxicología | en_US |
dc.subject | 320101 Oncología | en_US |
dc.subject.other | Breast cancer | en_US |
dc.subject.other | Gene expression | en_US |
dc.subject.other | HMEC | en_US |
dc.subject.other | Organochlorine mixtures | en_US |
dc.subject.other | Xenoestrogens | en_US |
dc.title | Differential gene expression pattern in human mammary epithelial cells induced by realistic organochlorine mixtures described in healthy women and in women diagnosed with breast cancer | en_US |
dc.type | info:eu-repo/semantics/Article | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.toxlet.2016.02.003 | en_US |
dc.identifier.scopus | 84957831403 | - |
dc.identifier.isi | 000370525300006 | - |
dcterms.isPartOf | Toxicology Letters | |
dcterms.source | Toxicology Letters[ISSN 0378-4274],v. 246, p. 42-48 | |
dc.contributor.authorscopusid | 56830230000 | - |
dc.contributor.authorscopusid | 15829708200 | - |
dc.contributor.authorscopusid | 6507534124 | - |
dc.contributor.authorscopusid | 56149756400 | - |
dc.contributor.authorscopusid | 6603459604 | - |
dc.contributor.authorscopusid | 6603916807 | - |
dc.contributor.authorscopusid | 6603469417 | - |
dc.description.lastpage | 48 | en_US |
dc.description.firstpage | 42 | en_US |
dc.relation.volume | 246 | en_US |
dc.investigacion | Ciencias de la Salud | en_US |
dc.type2 | Artículo | en_US |
dc.identifier.wos | WOS:000370525300006 | - |
dc.contributor.daisngid | 27812108 | - |
dc.contributor.daisngid | 465624 | - |
dc.contributor.daisngid | 418704 | - |
dc.contributor.daisngid | 865329 | - |
dc.contributor.daisngid | 418822 | - |
dc.contributor.daisngid | 1656886 | - |
dc.contributor.daisngid | 1146740 | - |
dc.identifier.investigatorRID | B-4495-2010 | - |
dc.identifier.investigatorRID | A-9640-2017 | - |
dc.identifier.investigatorRID | No ID | - |
dc.utils.revision | Sí | en_US |
dc.contributor.wosstandard | WOS:Rivero, J | - |
dc.contributor.wosstandard | WOS:Henriquez-Hernandez, LA | - |
dc.contributor.wosstandard | WOS:Luzardo, OP | - |
dc.contributor.wosstandard | WOS:Pestano, J | - |
dc.contributor.wosstandard | WOS:Zumbado, M | - |
dc.contributor.wosstandard | WOS:Boada, LD | - |
dc.contributor.wosstandard | WOS:Valeron, PF | - |
dc.date.coverdate | Marzo 2016 | en_US |
dc.identifier.ulpgc | Sí | en_US |
dc.contributor.buulpgc | BU-MED | en_US |
dc.description.sjr | 1,25 | |
dc.description.jcr | 3,858 | |
dc.description.sjrq | Q1 | |
dc.description.jcrq | Q1 | |
dc.description.scie | SCIE | |
item.grantfulltext | none | - |
item.fulltext | Sin texto completo | - |
crisitem.author.dept | Departamento de Ciencias Médicas y Quirúrgicas | - |
crisitem.author.dept | GIR IUIBS: Medio Ambiente y Salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Medio Ambiente y Salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Medio Ambiente y Salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.dept | GIR IUIBS: Medio Ambiente y Salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Medio Ambiente y Salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Ciencias Clínicas | - |
crisitem.author.dept | GIR IUIBS: Medio Ambiente y Salud | - |
crisitem.author.dept | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.dept | Departamento de Bioquímica y Biología Molecular, Fisiología, Genética e Inmunología | - |
crisitem.author.orcid | 0000-0003-3237-0316 | - |
crisitem.author.orcid | 0000-0002-4153-3028 | - |
crisitem.author.orcid | 0000-0001-6454-4785 | - |
crisitem.author.orcid | 0000-0002-1534-7758 | - |
crisitem.author.orcid | 0000-0002-0195-4565 | - |
crisitem.author.orcid | 0000-0001-5865-7003 | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.parentorg | IU de Investigaciones Biomédicas y Sanitarias | - |
crisitem.author.fullName | Figueroa Rivero, Javier | - |
crisitem.author.fullName | Henríquez Hernández, Luis Alberto | - |
crisitem.author.fullName | Pérez Luzardo, Octavio Luis | - |
crisitem.author.fullName | Pestano Brito, José Juan | - |
crisitem.author.fullName | Zumbado Peña, Manuel Luis | - |
crisitem.author.fullName | Domínguez Boada, Luis María | - |
crisitem.author.fullName | Fernández Valerón, Josefa Pilar | - |
Appears in Collections: | Artículos |
SCOPUSTM
Citations
15
checked on Oct 13, 2024
WEB OF SCIENCETM
Citations
17
checked on Oct 13, 2024
Page view(s)
58
checked on May 11, 2024
Google ScholarTM
Check
Altmetric
Share
Export metadata
Items in accedaCRIS are protected by copyright, with all rights reserved, unless otherwise indicated.